Harry Karmouty-Quintana, Ph.D.

Assistant Professor
BCB Graduate Program


Description of Research

Please visit Dr. Karmouty-Quintana’s official lab webpage here … http://www.karmoutylab.com/

 

ResearchMechanisms of Pulmonary Hypertension associated with Chronic Lung Diseases. Chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are currently the 3rd largest killers in the US. An important and deadly complication of COPD and IPF is the development of Pulmonary Hypertension (PH). PH is a deadly disorder that is characterized by remodeling of the vasculature, increased blood pressure in the pulmonary circulation (>25mmHg) that results in right-sided heart attack and death. Currently, there are no treatments available for this disorder, in part due to our lack of understanding of the pathogenesis of PH in patients with chronic lung disease. Our research has identified the adenosine A2B receptor, a receptor that is elevated following conditions of cell injury and stress, and hyaluronan, a component of the lung extracellular matrix, as potential targets for the treatment of PH in chronic lung disease. Our research efforts are focused on uncovering the mechanisms of adenosine signaling and hyaluronan that lead to PH in chronic lung disease.

Fun Facts: I previously trained in Montreal, Quebec at McGill University from 2006 to 2010 where I completed my first postdoc on airway smooth muscle remodeling in asthma. Prior to that I lived in Basel, Switzerland, where I pursued my PhD on “Experimental Pulmonary Diseases assessed by Magnetic Resonance Imaging”, a joint venture with Novartis and King’s College London (UK) where I graduated in 2006. Having spent a lot of time in cold countries, I was happy to move to Houston in May 2010 where I started as a postdoc and was promoted to Research Assistant Professor in September 2012. Other than lung diseases, I am interested in ocean life; I have a saltwater aquarium at home and I am a certified scuba diver! Originally from Barcelona, I may be hard to find if FC Barcelona is playing a champions league game or against Real Madrid!

Select Publications:

  1. Karmouty-Quintana H, Weng T, Garcia-Morales LJ, Chen NY, Pedroza M, Zhong H, Molina JG, Bunge R, Bruckner BA, Xia Y, Johnston RA, Loebe M, Zeng D, Seethamraju H, Belardinelli L, Blackburn MR. ADORA2B and hyaluronan modulate pulmonary hypertension associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol In press, 2013.
  2. Karmouty-Quintana H, Xia Y, Blackburn MR. Adenosine signaling during acute and chronic disease states. J Mol Med (Berl) 91(2):173-81, 2013.
  3. Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, Xia Y, Johnston RA, Zeng D, Belardinelli L, Blackburn MR. The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB J  26(6):2546-57, 2012.
  4. Karmouty-Quintana H, Siddiqui S, Hassan M, Tsuchiya K, Risse PA, Xicota-Vila L, Marti-Solano M, Martin JG. Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure. Am J Physiol Lung Cell Mol Physiol 302(8):L736-45, 2012.
  5. Karmouty-Quintana H, Tamimi F, McGovern TK, Grover LM, Martin JG, Barralet JE. Sustained steroid release in pulmonary inflammation model. Biomaterials 31(23):6050-9, 2010.
  6. Karmouty-Quintana H, Blé FX, Cannet C, Zurbruegg S, Fozard JR, Page CP, Beckmann N. In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI. Br J Pharmacol 154(5):1063-72, 2008.
  7. Karmouty-Quintana H, Cannet C, Zurbruegg S, Blé FX, Fozard JR, Page CP, Beckmann N. Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI. J Magn Reson Imaging 26(4):941-9, 2007.
  8. Karmouty-Quintana H, Cannet C, Sugar R, Fozard JR, Page CP, Beckmann N. Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging. Br J Pharmacol 150(8):1022-30, 2007.
  9. Karmouty Quintana H, Mazzoni L, Fozard JR. Effects of endotoxin and allergen alone and in combination on the sensitivity of the rat airways to adenosine. Auton Autacoid Pharmacol 25(4):167-70, 2005.

Contact Information

Harry.Karmouty@uth.tmc.edu

UTHealth Medical School

Department of Biochemistry and Molecular Biology
6431 Fannin Street, MSB 6.214
Houston, Texas 77030

713-500-5331  Direct  713-500-0652 Fax

Lab:  MSB 6.310; 713-500-6034 

Education

Ph.D. - King's College London

Postdoctoral Fellow - McGill University, Canada

Research Interests

Mechanisms of pulmonary hypertension (PH) associated with chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF); Mechanisms of adenosine signaling and hyaluronan that lead to PH in chronic lung diseases.

Publications

Adenosine A2B receptor and hyaluronan modulate pulmonary hypertension associated with chronic obstructive pulmonary disease

Karmouty-Quintana H, Weng T, Garcia-Morales LJ, Chen NY, Pedroza M, Zhong H, Molina JG, Bunge R, Bruckner BA, Xia Y, Johnston RA, Loebe M, Zeng D, Seethamraju H, Belardinelli L, Blackburn MR.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1038-47.

read more
Adenosine signaling during acute and chronic disease states

Karmouty-Quintana H, Xia Y, Blackburn MR.

J Mol Med (Berl) 91(2):173-81, 2013.

PMCID: PMC3606047

read more
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease

Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, Xia Y, Johnston RA, Zeng D, Belardinelli L, Blackburn MR.

FASEB J  26(6):2546-57, 2012

PMCID:PMC3650483

read more
Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure

Karmouty-Quintana H, Siddiqui S, Hassan M, Tsuchiya K, Risse PA, Xicota-Vila L, Marti-Solano M, Martin JG.

Am J Physiol Lung Cell Mol Physiol 302(8):L736-45, 2012.

PMID: 22287614

read more
Sustained steroid release in pulmonary inflammation model

Karmouty-Quintana H, Tamimi F, McGovern TK, Grover LM, Martin JG, Barralet JE.

Biomaterials 31(23):6050-9, 2010.

 

 

read more
In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI.

Karmouty-Quintana H, Blé FX, Cannet C, Zurbruegg S, Fozard JR, Page CP, Beckmann N.

Br J Pharmacol 154(5):1063-72, 2008.

PMCID: PMC2451044

read more
Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI.

Karmouty-Quintana H, Cannet C, Zurbruegg S, Blé FX, Fozard JR, Page CP, Beckmann N.

J Magn Reson Imaging 26(4):941-9, 2007

 

read more
Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging

Karmouty-Quintana H, Cannet C, Sugar R, Fozard JR, Page CP, Beckmann N.

Br J Pharmacol 150(8):1022-30, 2007

PMCID: PMC2013907

read more
Effects of endotoxin and allergen alone and in combination on the sensitivity of the rat airways to adenosine.

Karmouty Quintana H, Mazzoni L, Fozard JR.

Auton Autacoid Pharmacol 25(4):167-70, 2005.

 

read more
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