Vasanthi Jayaraman, Ph.D.

Professor
2016 McGovern Scholar, 2016 Co-Chair Biophysical Society Annual Meeting


Description of Research

STRUCTURE AND FUNCTION OF NEUROTRANSMITTER RECEPTORS

Communication between nerve cells serves as the basis of all brain activity, and one of the fundamental steps involved in signal transmission between the nerve cells, is the conversion of a “chemical” signal liberated at the end of one nerve cell, into an “electrical” signal at the second nerve cell. This step is mediated by a class of membrane bound proteins known as neurotransmitter receptors. Glutamate receptors belong to this family of proteins, and are the main excitatory receptors in the central nervous system.

Our laboratory is interested in gaining an understanding of agonist mediated activation and desensitization of this receptor by determining the structural changes in the protein induced by agonist binding. This is achieved by using various cutting edge spectroscopic methods that allow the characterization of the dynamic state structure of the proteins at a significantly higher resolution than X-ray structures. The structural changes thus determined are correlated to the functional consequences as measured by electrophysiological measurements. These investigations provide a detailed understanding of the agonist controlled function of the glutamate receptors and hence aid in the rational design of drugs targeting this group of important proteins that are involved in diverse neuropathologies, such as epilepsy and ischemia.

Jayaraman_Faculty_Image

 Chemical interactions, dynamics and function

Contact Information

Vasanthi.Jayaraman@uth.tmc.edu

UTHealth Medical School
Department of Biochemistry and Molecular Biology
6431 Fannin Street, MSB 6.174
Houston, Texas 77030

713-500-6236 Direct  713-500-0652 Fax

Education

PhD - Princeton University

Postdoctoral Fellow - Cornell University

Research Interests

Structure and function of Membrane proteins , Ligand gated ion channels

Publications

Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.

MacLean DM1, Jayaraman V2.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2504-E2513. doi: 10.1073/pnas.1620508114. Epub 2017 Mar 6.

PMID:28265090

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Stargazin Modulation of AMPA Receptors.

Shaikh SA1, Dolino DM2, Lee G1, Chatterjee S3, MacLean DM1, Flatebo C4, Landes CF5, Jayaraman V6.

Cell Rep. 2016 Oct 4;17(2):328-335. doi: 10.1016/j.celrep.2016.09.014.

PMID:27705782

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