Seung-Hee (Sally) Yoo, Ph.D.

Assistant Professor
BCB Graduate Program


Description of Research

In response to daily environmental changes imposed by Earth’s rotation, almost all species, ranging from cyanobacteria to humans, have evolved physiological and behavioral rhythms, called circadian rhythms. Circadian rhythms are not passive responses to environmental changes; rather, they are driven by an active clock system, capable of anticipating changes and coordinating tissue specific function and generating systemic output responses. The harmony between our intrinsic biological timing and the daily environmental oscillation is critical to physiological well-being; conversely, disrupted circadian rhythms have been shown to cause or increase the risk of various chronic diseases. In our lab, we focus on delineating fundamental cellular mechanisms in circadian rhythms and also deciphering physiological and pathological roles of the clock. Our long-term goal is to translate such fundamental mechanistic knowledge into new drug targets and therapeutic strategies for improved prevention and treatment of chronic diseases.

yooFIG1

Figure 1. Comparison of real-time bioluminescence analysis of circadian expression of Per2::Luc and Per2::LucSV. Left panels: representative bioluminescence traces. Right panels: periods from individual replicates.

Currently, our lab are pursuing several projects, using an integrative approach combining mouse models with molecular and cellular mechanistic studies. In one project, we investigate the role of miRNAs in circadian clock regulation using a second-generation circadian reporter mouse line Per2::LucSV (Figure 1), with a particular focus on the mechanistic relationship between clock robustness and metabolic health. In another project, we investigate the role of a circadian E3 ligase in heart failure induced skeletal muscle atrophy using a novel mouse model. Finally, we continue to pursue cloning of novel circadian clock mutants recently identified by a recessive mouse genetic screen.

Contact Information

Seung-Hee.Yoo@uth.tmc.edu

UTHealth Medical School
Department of Biochemistry and Molecular Biology
6431 Fannin Street, MSB 6.178
Houston, Texas 77030

713-500-6136  Direct  713-500-0652 Fax

Education

Ph.D. - Korea Advanced Institute of Science and Technology

Publications

Yoo, Seung-Hee

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