My laboratory focuses on translational research of cardiovascular diseases including hypertension, preeclampsia, priapism, chronic kidney disease and blood disorders (sickle cell disease). Our goal is to translate our discovery-driven basic science smoothly and quickly to clinics to benefit human health. To accomplish this goal, we have conducted multiple non-biased screening (including metabolomic screening and gene array) to identify potential pathogenic markers for the diseases. Extending from our initial screen, we have conducted preclinical studies using both pharmacological and genetic approaches to determine the pathophysiological role of these newly identified molecules in the disease in animal models. Finally, we have conducted human translational research to determine whether these newly identified pathogenic markers are diagnostic makers for early detection and therapeutic targets for the diseases. Overall, we use three platforms including non-biased screen, preclinical animal studies and human translational studies to perform translational research in multiple cardiovascular diseases (summary see Figure 1).
We have acquired significant research experience in most areas of biochemistry, molecular genetics, physiology, histology, hematology and vascular biology needed to conduct translational medicine. Our studies have provided significant new insight to the pathogenesis of complicated cardiovascular diseases and reveal novel therapeutic possibilities for the diseases.
UTHealth Medical School
Department of Biochemistry and Molecular Biology
6431 Fannin Street, MSB 6.202
Houston, Texas 77030
713-500-5039 Direct 713-500-0652 Fax
MD - XiangYa Medical School, Hunan, China
Ph.D. - Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston
Postdoctoral Fellow - The University of Texas Medical School at Houston
Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, Popek EJ, Hicks MJ, Ramin SM, Kellems RE, Xia Y.
Nat Med. 2008 Aug;14(8):855-62. doi: 10.1038/nm.1856. Epub 2008 Jul 27.
Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y.
Nat Med. 2011 Jan;17(1):79-86. doi: 10.1038/nm.2280. Epub 2010 Dec 19.
Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW, Molina JG, Weisbrodt NW, Kellems RE, Blackburn MR, Xia Y.
J Clin Invest. 2008 Apr;118(4):1491-501. doi: 10.1172/JCI33467.