Yang Xia, M.D., Ph.D.
Professor


Description of Research

My laboratory focuses on translational research of cardiovascular diseases including hypertension, preeclampsia, priapism, chronic kidney disease and blood disorders (sickle cell disease). Our goal is to translate our discovery-driven basic science smoothly and quickly to clinics to benefit human health.  To accomplish this goal, we have conducted multiple non-biased screening (including metabolomic screening and gene array) to identify potential pathogenic markers for the diseases.  Extending from our initial screen, we have conducted preclinical studies using both pharmacological and genetic approaches to determine the pathophysiological role of these newly identified molecules in the disease in animal models.  Finally, we have conducted human translational research to determine whether these newly identified pathogenic markers are diagnostic makers for early detection and therapeutic targets for the diseases.  Overall, we use three platforms including non-biased screen, preclinical animal studies and human translational studies to perform translational research in multiple cardiovascular diseases (summary see Figure 1).

Figure 1. Our laboratory conducts translational studies in multiple cardiovascular diseases including hypertension, preeclampsia, priapism, chronic kidney diseases and blood disorder (sickle cell disease).

Figure 1. Our laboratory conducts translational
studies in multiple cardiovascular diseases including
hypertension, preeclampsia, priapism, chronic kidney
diseases and blood disorder (sickle cell disease).

We have acquired significant research experience in most areas of biochemistry, molecular genetics, physiology, histology, hematology and vascular biology needed to conduct translational medicine.    Our studies have provided significant new insight to the pathogenesis of complicated cardiovascular diseases and reveal novel therapeutic possibilities for the diseases.

Contact Information

Yang.Xia@uth.tmc.edu

UTHealth Medical School
Department of Biochemistry and Molecular Biology
6431 Fannin Street, MSB 6.202
Houston, Texas 77030

713-500-5039 Direct  713-500-0652 Fax

Education

MD - XiangYa Medical School, Hunan, China

Ph.D. - Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston

Postdoctoral Fellow - The University of Texas Medical School at Houston

Publications

Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice.

Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, Popek EJ, Hicks MJ, Ramin SM, Kellems RE, Xia Y.

Nat Med. 2008 Aug;14(8):855-62. doi: 10.1038/nm.1856. Epub 2008 Jul 27.

PMID: 18660815

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Detrimental effects of adenosine signaling in sickle cell disease.

Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y.

Nat Med. 2011 Jan;17(1):79-86. doi: 10.1038/nm.2280. Epub 2010 Dec 19.

PMID: 21170046

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Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling.

Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW, Molina JG, Weisbrodt NW, Kellems RE, Blackburn MR, Xia Y.

J Clin Invest. 2008 Apr;118(4):1491-501. doi: 10.1172/JCI33467.

PMID: 18340377

 

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