Lab News

October 2020, Paper: Youqiong’s paper titled “YTHDF3 Induces the Translation of m6A-enriched Metastasis-associated Gene Transcripts to Promote Breast Cancer Brain Metastasis”  is accepted by Cancer Cell!

October 2020, Paper: Zhao’s paper titled “Systematic characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors”  is accepted by Genome Medicine!

October 2020, Paper: Zhao’s paper titled “HeRA: an atlas of enhancer RNAs across human tissues”  is accepted by NAR!

October 2020, Paper: Shengli’s paper titled “The mutational and transcriptional landscapes of hepatocarcinogenesis in a rat model”  is accepted by iScience!

September 2020, Shengli will start his own lab at Shanghai Jiaotong University in September!

August 2020, Paper: Ying’s paper titled “Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy”  is accepted by Nature Communications!

August 2020, Paper: Ying’s paper titled “Adverse events associated with potential drugs for COVID-19: a case study from real-world data”  is accepted by Briefings in Bioinformatics!

June 2020, Paper: Yaoming/Hang’s paper titled “The genetic and pharmacogenomic landscape of snoRNAs in human cancer”  is accepted by Molecular Cancer!

June 2020, Award: Zhao was awarded Post-doctoral Fellowship from UTHealth Innovation for Cancer Prevention Research Training Program, Shengli was on the finalist! Congratulations!

May 2020, Paper: Shengli/Zhao’s spotlight titled “3D spheroids propel tumor characterization”  is published by Trends in Cancer!

April 2020, Paper: Youqiong’s paper titled “Sex-associated molecular differences for cancer immunotherapy.”  is published by Nature Communications!

March 2020, Paper: Youqiong’s collaborative paper titled “ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis” is published by Cancer Cell!

February 2020, Paper: With ICGC PCAWG Consortium, we published at Nature/Nature Genetics!

February 2020, Paper: Youqiong/ Zhao’s review paper titled “A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine”  is published by Trends in Genetics!

January 2020, Youqiong start her own lab at Shanghai Jiaotong University!

December 2019, Paper: Yaoming’s book chapter titled “Expression Quantitative Trait Loci (eQTL) Analysis in Cancer” is published by Methods Molecular Biology!

December 2019, Paper: Zhao/Shengli’s paper titled “Resolving Spliceosomal Malfunctions Advances RNA-Based Therapeutics” is published by Trends in Molecular Medicine!

November 2019, Paper: Hang’s paper titled “Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment” is published by BMC Biology!

September 2019, Paper: Shengli/Zhao’s paper titled “Molecular Treasures of Cancer Cell Lines” is accepted by Trends in Molecular Medicine!

September 2019, Paper: Zhao/Hang’s paper titled “Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer” is accepted by Nature Communications!

September 2019, Paper: Wei/Hang’s paper titled “APAatlas: decoding alternative polyadenylation across human tissues” is accepted by Nucleic Acids Research!

August 2019, Paper: Hang/Yu/Shengli’s paper titled “Comprehensive characterization of circular RNAs in ~1000 human cancer cell lines” is accepted by Genome Medicine!

August 2019, Paper: Through collaboration with Dr. Chen, Youqiong’s paper titled “Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge” is accepted by Nature Communications!

August 2019, Paper: Through collaboration with Dr. Wang from Methodist, our paper titled “Myeloid Loss of Becn1 Promotes the Development of PD-L1hi Precursor B Cell Lymphoma” is accepted by The Journal of Clinical Investigation!

June 2019, Paper: Youqiong’s paper in collaboration with Drs. Yang/Lin at MDACC titled “Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression” is published by Nature Immunology! Congratulations!

June 2019, Paper: Through collaboration with Dr. Xia, Youqiong’s paper titled “Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality” is published by FASEB J! Congratulations!

March 2019, Paper: Youqiong’s paper titled “Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy” is published by Nature Metabolism and featured as the cover story! Congratulations!

NM_cover

March 2019, Paper: Shengli’s commentary paper titled “Circular RNAs as promising biomarkers in cancer: detection, function, and beyond” is published by Genome Medicine! Congratulations!

January 2019, Paper: Through collaboration with Dr. Zhou at Texas A&M, our paper titled “Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma” is published by Cell Chemical Biology and featured as the cover story! Congratulations!

CC Bio Cover

January 2019, Paper: Yu’s collaborative paper with Dr. Blackburn titled “Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation” is published by The Journal of Clinical Investigation!

January 2019, Paper: Through collaboration with Xiaoping Miao at Huazhong University of Science and Technology,  our paper titled “CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer” is published at Nucleic Acids Research! Congratulations!

November 2018, Paper: Through collaboration with Dr. Zhou at Texas A&M, our paper titled “TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10” is published by PloS Biology! Congratulations!

September 2018, Paper: Jing’s paper titled “Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer” is published at Nucleic Acids Research! Congratulations!

April 2018, Jing start her own lab at Huazhong Agriculture University!

March 2018, Paper: Through collaboration with Dr. Liang at MDACC, our paper titled “A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer” is published by Cancer Cell! Congratulations!

January 2018, Paper: Yu’s collaborative paper with Dr. Xi Chen (BCM) titled “Pharmacological Targeting of Myc-regulated IRE1/XBP1 Pathway Suppresses MYC-Driven Breast Cancer” is accepted by The Journal of Clinical Investigation! Congratulations!

December 2017, Paper: Youqiong’s paper titled “The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy” is accepted in principle by Cell Systems! Congratulations!

Cell Systems Cover

December 2017, Award: Jing renewed her Post-doctoral Fellowship from UTHealth Innovation for Cancer Prevention Research Training Program, Congratulations!

December 2017, Paper: Hang’s commentary paper titled “Regulatory RNA editing sites in cancer: prediction and beyond” is accepted by EbioMedicine! Congratulations!

December 2017, Personnel: Dr. Tingming Liang from Nanjing Normal University joined our lab as Visiting Scholar, welcome!

November 2017, Personnel: Dr. Jiewei Liu from the Chinese Academy of Sciences joined our lab as a Postdoc Fellow, welcome!

October 2017, Personnel: Dr. Hang Ruan from Fudan University joined our lab as a Postdoc Fellow, welcome!

October 2017, Paper: Jing Gong/Chun-jie/Yu Xiang’s paper titled “A pan-cancer analysis of the expression and clinical relevance of small nucleolar RNAs in human cancer” is accepted by Cell Reports and featured as the cover story! Congratulations!

Cell Reports Cover

 

September 2017, Paper: Yu Xiang/Youqiong Ye’s paper titled “Comprehensive characterization of alternative polyadenylation in human cancer” is accepted by The Journal of the National Cancer Institute! Congratulations!

September 2017, Paper: Jing Gong’s paper titled “PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types” is accepted by Nucleic Acids Research! Congratulations!

September 2017, Paper: Jing Feng’s paper titled “CSCD: A database for cancer-specific circular RNAs” is accepted by Nucleic Acids Research! Congratulations!

August 2017, Paper: Through collaboration with Dr. Fabbri at USC, the paper titled “Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs” is accepted in principle by Nature Communications!

July 2017, Paper: Through collaboration with Dr. Gan at MDACC, the paper titled “Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development” is accepted in principle by Nature Communications!

May 2017, Paper: Jing/Yu’s paper titled “CircView: A Visualization and Exploration Tool for Circular RNAs” is accepted by Briefings in Bioinformatics! Congratulations!

May 2017, Paper: Through collaboration with Dr. Shyu, the paper titled “Antagonistic actions of two human Pan3 isoforms on global mRNA turnover” is accepted by RNA! Yu is the co-author! congratulations!

April 2017, Paper: Through collaboration with Dr. Han Liang at MDACC, we published a paper titled “Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers” on Genome research, and featured on the cover!

Genome Research cover

March 2017, Award: Dr. Yu Xiang and Ms. Youqiong Ye received presentation awards at BMB retreat, congratulations!

January 2017, Paper: With TCGA Research Network, the paper “Integrated genomic and molecular characterization of cervical cancer” is accepted by Nature!

January 2017, Paper: Through collaboration with Dr. He from Wuhan University, our paper titled “Genome-wide characterization of lncRNAs in acute myeloid leukemia” is accepted by Briefings in Bioinformatics! Jing Feng is the co-author! Congratulations!

December 2016, Paper: Through collaboration with Drs. Liuqing Yang & Chunru Lin at MDACC, our paper titled “The LINK-A lncRNA interacts with PI(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors” is accepted by Nature Cell Biology!

December 2016, Personnel: Dr. Jing Xu from Ohio State University joined our lab as a Postdoc Fellow, welcome!

November 2016, Paper: Through collaboration with Drs. Liuqing Yang & Chunru Lin at MDACC, our paper titled “A ROR1-HER3-LncRNA signaling axis modulates the Hippo-YAP pathway to regulate bone metastasis” is accepted by Nature Cell Biology!

November 2016, Paper: Through collaboration with Dr. Yang Xia, our paper titled “Erythrocytes retain “hypoxic adenosine response” for faster acclimatization upon re-ascent” is accepted by Nature Communications!

November 2016, Award: Dr. Jing Gong received a Post-doctoral Fellowship from UTHealth Innovation for Cancer Prevention Research Training Program, Congratulations!

November 2016, Personnel: Dr. Zhao Zhang from Fudan University joined our lab as a Postdoc Fellow, welcome!

October 2016, Personnel: Mr. Chunjie Liu from Huazhong University of Science and Technology joined our lab as a visiting PhD student, welcome!

September 2016, Personnel: Ms. Fatma MÜGE ÖZGÜÇ from the University of California Berkeley joined our lab as Research Assistant, welcome!

September 2016, Personnel: Mr. Perry Lee from the University of Houston joined our lab through UT Pre-Baccalaureate Program, welcome!

September 2016, Paper: Jing Gong/Chunjie’s paper titled “LNCediting: a database for functional effects of RNA editing in lncRNAs ” is accepted by Nucleic Acids Research! Congratulations!

August 2016, Personnel: Ms. Youqiong Ye from Tongji University joined our lab as the Predoc Fellow, welcome!

August 2016, Paper: Jing Feng’s paper titled “Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes” is accepted by Briefings in Bioinformatics! Congratulations!

August 2016, Personnel: Dr. Jing Feng from Wuhan University Joined our lab as the Visiting Associate Professor, welcome!

July 2016, Paper: Through collaboration with Dr. Ju-Seog Lee from MD Anderson Cancer Center and Dr. Hyun-Sung Lee from Baylor College of Medicine, our paper titled “Integrated Genomic Analysis of Recurrence-Associated Small Non-coding RNAs in Oesophageal Cancer”” is accepted by Gut!

June 2016, Paper: Through collaboration with Drs. Guang Hu & Li Wang at NIEHS, our paper titled “INO80 governs super-enhancer- mediated oncogenic transcription and tumor growth in melanoma” is accepted by Genes & Development!

May 2016, Paper: Through collaboration with Drs. Gerry Melino and Eleonora Candi at University of Rome, Italy, our paper titled “Ultraconserved long non-coding RNA uc.63 in breast cancer” is accepted by Oncotarget!

April 2016, Personnel: Dr. Jing Gong from Huazhong University of Science and Technology (HUST) joined our lab as the Postdoc Fellow, welcome!

March 2016, Personnel: Martha Czernuszenko joined our lab through UT Pre-Baccalaureate Program, welcome!

February 2016, Paper: Through collaboration with Dr. Boyi Gan at MDACC, our paper titled “LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress” is accepted by Nature Cell Biology!

January 2016, Personnel: Dr. Yu Xiang from Shanghai Institutes of Biological Sciences (SIBS) joined our lab as the first Postdoc Fellow, welcome!

January 2016, Paper: Through collaboration with Dr. George Calin at MDACC, our paper titled “Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2″ is accepted by Molecular Cell!

December 2015, Paper: Through collaboration with Drs. Liuqing Yang & Chunru Lin at MDACC, our paper titled “The LINK-A lncRNA activates normoxic HIF1α signaling in triple-negative breast cancer” is accepted by Nature Cell Biology!

November 2015, Paper: Our author’s view “RNA Editing in Cancer: Mechanistic, Prognostic and Therapeutic Implications” is accepted by Molecular & Cellular Oncology!

October 2015, Award: Through collaboration with Dr. Karmouty-Quintana, we received an award from UTHealth Pulmonary Center of Excellence!

September 2015, Han lab is launched at Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston

August 2015, Award: Dr. Han was awarded a $2M funding for the Recruitment of First-Time, Tenure-Track Faculty Members from Cancer Prevention & Research Institute of Texas (CPRIT)!

August 2015, Paper: Our RNA editing paper titled “The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers” is accepted by Cancer Cell!

  • MD Anderson news release “Study shows new ‘driver’ to assess cancer patient survival and drug sensitivity”, October 1st, 2015
  • News article “New driver to assess cancer patient survival, drug sensitivity” at Science Daily, October 1st, 2015
  • News article “MD Anderson Study Shows Differential RNA editing in Cancer Cells” at GenomeWeb, October 2nd, 2015
  • Highlighted by Nature Reviews Cancer “The relevance of extensive editing in tumor transcriptomes”
  • Highlighted by Cancer Discovery “Aberrant RNA Editing Is A Potential Driver In Cancer”
  • Highlighted by TCGA Consortium “Researchers Use TCGA Data for First Pan-Cancer Analyses of RNA-Editing”
  • Spotlight by Trends in Cancer “RNA Editing Dynamically Rewrites the Cancer Code”
  • Highlighted by Science Signaling as 2015 Signaling Breakthrough of the Year

July 2015, Paper: Our TANRIC paper is published in Cancer Research!

May 2015, Award: Dr. Han was awarded the Ben F. Love Fellowship in Innovative Cancer Therapies!

May 2015, Award: Dr. Han was awarded The Second Prize for Outstanding Performance and Excellence in Scientific Presentation, The 29th SCBA-Texas Chapter Annual Symposium, Houston, TX