Tingting Weng, PhD
Lab: MSB 6.034
Research: Investigating the role of deoxyadenosine signaling in chronic lung disease and the role of adenosine signaling in acute lung injury. The goal of my research is to understand the mechanisms of hypoxia-induced deoxycytidine kinase (DCK) expression in chronic lung diseases; the role of DCK in these diseases is examined by using the DCK inhibitor 2′-deoxycytidine. Hypoxia and the DCK pathway are characterized utilizing lung samples from IPF and COPD patients. I have recently started a project to study the role of adenosine signaling in acute lung injury; my goal is to understand the molecular mechanisms of how adenosine can protect vascular leakage through the A2B receptor.
First Author Publications:
Weng T, Karmouty-Quintana H, Garcia-Morales LJ, Molina JG, Pedroza M, Bunge RR, Bruckner BA, Loebe M, Seethamraju H, Blackburn MR. Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease. FASEB J 27(5):2013-2026, 2013.