Soy lecithin NSAID combo drug protects against cancer with fewer side effects
When UTHealth scientists applied a chemical found in soybeans to a non-steroidal anti-inflammatory drug (NSAID), they increased its anticancer properties and reduced its side effects. Findings of the preclinical study of phosphatidylcholine, also called lecithin, appear in the journal Oncology Letters.
“The results support the potential use of NSAIDs associated with phosphatidylcholine for the prevention and treatment of colorectal cancer,” said Lenard Lichtenberger, Ph.D., the study’s lead investigator and a professor of integrative biology and pharmacology at McGovern Medical School at UTHealth.
The NSAID indomethacin associated with phosphatidylcholine was studied in a head-to-head comparison with three other NSAIDs (one of them aspirin). According to the results, the combination provided superior colorectal cancer protection with less gastrointestinal bleeding. The study was conducted in a mouse model and in laboratory experiments.
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