2008 Publications

  • Abankwa D, Gorfe AA and Hancock JF(2008). Mechanisms of Ras membrane organization and signaling: Ras on a rocker. Cell Cycle, 7, 2667-2673.
  • Abankwa D, Hanzal-BayerM, Ariotti N, Plowman SJ, Gorfe AA, Parton RG, McCammon JA and Hancock JF (2008). A novel switch region regulates H-ras membrane orientation and signal output. EMBO J, 27, 727-735.
  • Babakhani A, Gorfe AA, Kim JE and McCammon JA (2008). Thermodynamics of peptide insertion and aggregation in a lipid bilayer. J Phys Chem 112, 10528-10534.
  • Belanis L, Plowman SJ, Rotblat B, Hancock JF and Kloog Y (2008) Galectin-1 is a novel structural component and major regulator of H-ras nanoclusters. Mol Biol Cell, 19, 1404-1414.
  • Bhattacharya R, Frankfurter A, and Cabral F (2008). A minor b-tubulin essential for mammalian cell proliferation. Cell Motil Cytoskel, 65, 708-720.
  • Bian K, Doursout MF, Murad F (2008) Vascular system: Role of nitric oxide in cardiovascular disease.  J Clin Hyperten, 10, 304-310.
  • Boerma M, Fu Q, Wang J, Loose DS, Bartolozzi A, Ellis JL, McGonigle S, Paradise E, Sweetnam P, Fink LM, Vozenin-Brotons MC, Hauer-Jensen M (2008) Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin. Blood Coagul Fibrinolysis 19, 709-18.
  • Bonsra AN, Yonekubo J and Du G (2008). RNA interference expression vectors based on miRNAs and RNA splicing. In Current Perspectives in microRNAs (miRNA), S.-Y. Ying, ed. (Springer Sciences+business Media, B.V., 2008), pp. 35-50.
  • Brown RC, Wu L, Hicks K and O’Neil RG (2008). Regulation of blood-brain barrier permeability by transient receptor potential type C and type v calcium-permeable channels. Microcirculation, 15, 359-371.
  • Cabral F (2008). Mechanisms of resistance to drugs that interfere with microtubule assembly. Fojo, A. T., ed. (Totowa, NJ: Humana Press Inc.), pp. 329-348.
  • Carmon KS, Loose DS (2008) Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Mol Cancer Res, 6, 1017-28.
  • Carmon KS, Loose DS (2008) Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP. Biochem Biophys Res Commun. 368, 285-291.
  • Cheng G, Zile MR, Takahashi M, Baicu CF, Bonnema DD, Cabral F, Menick DR, and Cooper G (2008) A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart. Am J Physiol Heart Circ Physiol, 294, H2231-H2241.
  • Cheng H, Ross JA, Frost JA, and Kirken, RA (2008) Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity. Mol Cell Biol, 28, 2271-2282.
  • Cinelli AR, Efendiev R, and Pedemonte CH (2008) Trafficking of Na-K-ATPase and dopamine receptor molecules induced by changes in intracellular sodium concentration of renal epithelial cells. Am J Physiol Renal Physiol, 295, F1117-F1125.
  • Coconaur CS, Dial EJ, Lichtenberger L, Gonzalez EA, Kozar RA, Moore FA, and Mercer DW (2008). Gastric alkalinization following major trauma. J Trauma, 64, 681-687.
  • Doyen JR, Yucer N, Lichtenberger LM, and Kulmacz RJ (2008). Phospholipid actions on PGHS-1 and -2 cyclooxygenase kinetics. Prostaglandins Other Lipid Mediat, 85, 134-143.
  • Dial E, Lopez-Storey M, Adams S, Lichtenberger LM, Gonzalez E, McKinley B and Moore F (2008) A report on associations between gastric pH, bleeding, duodenogastric reflux and outcomes following trauma. J Trauma, 64, 105-110.
  • Dial EJ, Darling RL and Lichtenberger LM (2008) Importance of biliary excretion of indomethacin in gastrointestinal and hepatic injury. J Gastroenterol Hepatol, 23, e384-e389.
  • Dial EJ, Zayat M, Lopez-Storey M, Tran D and Lichtenberger L. (2008). Oral phosphatidylcholine preserves the gastrointestinal mucosal barrier during LPS-induced inflammation. Shock, 30, 729-733.
  • Efendiev R, Budu CE, Bertorello AM, Pedemonte CH (2008) GPCR-mediated traffic of Na,K-ATPase to the plasma membrane requires the binding of adaptor protein-1 to a Tyr-255 based sequence in the alpha-subunit. J Biol Chem, 283, 17561-17567.
  • Flatt CC, Warren-Morris D, Turner SD, Chan JT (2008) Effects of a stannous fluoride-impregnated dental floss on in vivo salivary fluoride levels.   J Dent Hyg, 82, 1-7.
  • Frost JA (2008) Net1. UCSD-Nature Molecule Pages (doi:10.1038/mp.a001630.01).
  • Ganguly A, Bhattacharya R, and Cabral F (2008) Cell cycle dependent degradation of MCAK: evidence against a role in anaphase chromosome movement. Cell Cycle, 7, 3187-3193.
  • Gorfe AA, Baron R and McCammon JA (2008) Water-membrane partition thermodynamics of an amphiphilic lipopeptide: an enthalpy-driven hydrophobic effect. Biophys J, 95, 3269-3277.
  • Gorfe AA, Chang CE, Ivanov I and McCammon JA (2008) Dynamics of the acetylcholinesterase tetramer. Biophys J, 94, 1144-1154.
  • Gorfe AA, Grant BJ and McCammon JA (2008) Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins. Structure, 16, 885-896.
  • Gorfe AA, and McCammon JA (2008) Similar membrane affinity of mono- and Di-S-acylated ras membrane anchors: a new twist in the role of protein lipidation. J Amer Chem Soc 130, 12624-12625.
  • Gu S, Anton A, Salim S, Blumer KJ, Dessauer CW and Heximer SP (2008) Alternative translation initiation of human RGS2 yields a set of functionally distinct proteins.  Mol. Pharm, 73, 1-11.
  • Guerra L, Carr H, Richter-Dahlfors A, Thelestam M, Masucci MG, Frost JA, and Frisan T (2008) A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a key effector in the response to DNA damage.  PLoS ONE, 3, e2254.
  • Harding A and Hancock JF (2008) Using plasma membrane nanoclusters to build better circuits. Trends Cell Sci, 18, 364-371.
  • Harding A and Hancock JF (2008) Ras nanoclusters: combining digital and analog signaling. Cell Cycle, 7, 127-134.
  • Hernández-Deviez DJ, Howes MT, Laval SH, Bushby K, Hancock JF and Parton RG. (2008) Caveolin regulates endocytosis of the muscle repair protein, dysferlin. J Biol Chem, 283, 6476-6488.
  • Hill MH, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VMJ, Martin S, Hancock JF, and Parton RG. (2008) PTRF, a novel, conserved caveolar coat protein that regulates caveolae formation and function. Cell, 132, 113-124.
  • Inder K, Harding A, Philips MR, Parton RG, and Hancock JF. (2008) Activation of the MAPK module from different spatial locations generates distinct system outputs. Mol Biol Cell, 19, 4776-4784.
  • Inder K., and Hancock JF (2008) System output of the MAPK module is spatially regulated. Commun Integ Biol, 1, 178-179.
  • Jin B., and Li Y-P (2008). Nitric Oxide Does Not Mediate Atrogin-1/MAFbx Upregulation by Inflammatory Mediators.  Basic Appl Myol, 18, 127-131.
  • Kirkham M, Nixon SJ, Howes MT, Abi-Rached L, Wakeham DE, Hanzal-Bayer M, Ferguson C, Hill MM, Fernandez-Rojo M, Brown DA, Hancock JF, Brodsky FM, Parton RG (2008) Evolutionary analysis and molecular dissection of caveola biogenesis.  J Cell Sci, 121, 2075-2076.
  • Kots A, Choi BK, Jiminez M, Warren C, Gilbertson S, Guerrant R and Murad F (2008) Novel inhibitors of cyclic nucleotide synthesis:  Application for treatment of diarrhea. Proc Natl Acad Sci USA, 105, 8440-8445.
  • Kots AY, Choi BK, Estrella-Jimenez ME, Warren CA, Gilbertson SR, Guerrant RL,
    Murad F (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea. Proc Natl Acad Sci USA. 105, 8440-8445.
  • Kozar RA, Weisbrodt NW, and Moore FA (2008) Gastrointestinal Failure, In: Trauma, Sixth Edition (Feliciano DV, Mattox KL, and Moore EE, eds) McGraw Hill, New York, 1281-1290.
  • Kunjilwar KK, Fishman HM, Englot  DJ, O’Neil  RG and Walters, ET. (2008). Long-Lasting Hyperexcitability Induced by Depolarization in the Absence of Detectable Ca2+ Signals. J Neurophysiol, in press.
  • Lanza FL, Marathi UK, Anand BS and Lichtenberger LM (2008). Clinical trial: comparison of ibuprofen-phosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients. Alimentary Pharmacol Ther, 28, 431-442.
  • Liang W, Hoang Q, Clark RB and Fishman PH (2008). Accelerated Dephosphorylation of the beta2-Adrenergic Receptor by Mutation of the C-Terminal Lysines: Effects on Ubiquitination, Intracellular Trafficking, and Degradation. Biochemistry, 47, 11750-11762.
  • Lichtenberger LM, Romero JJ, Dial EJ and Moore JE. (2008). Naproxen-PC: A GI safe and highly effective anti-inflammatory. Inflammopharmacol, 17, 1-5.
  • Liu Q, Dewi DA, Liu WS, Bee MS, Schonbrunn A. (2008) Distinct phosphorylation sites in the sst2 somatostatin receptor control internalization, desensitization, and arrestin binding. Mol Pharmacol 73, 292-304.
  • Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW., Molina JG, Weisbrodt NW, Kellems RE, Blackburn MR, and Xia Y (2008) Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest, 118, 1491-501.
  • Mujoo K, Sharin VG, Bryan NS, Krumenacker JS, Sloan C, Parveen S, Nikonoff LE, Kots AY, Murad F (2008) Role of nitric oxide signaling components in Differentiation of embryonic stem cells into myocardial cells. Proc Natl Acad Sci USA, 105, 18924-18929.
  • Mullani NA, Herbst RS, O’Neil, RG, Gould KL, Barron BJ and Abbruzzese JL (2008) Tumor blood flow measured by PET dynamic imaging of first-pass 18F-FDG uptake: a comparison with 15O-labeled water-measured blood flow. J Nucl Med 49, 517-523.
  • Murad F (2008). Nitric oxide and cyclic GMP signaling in the eye.  Can J Ophthalmol, 43, 291-294.
  • Piggott LA, Bauman A, Scott JD and Dessauer CW (2008) The A-Kinase Anchoring Protein Yotiao Binds and Regulates Adenylyl Cyclase in Brain. Proc Natl Acad Sci USA, 105, 13835-13840.
  • Plowman SJ, Ariotti N, Parton RG, and Hancock JF. (2008) Electrostatic interactions positively regulate K-Ras nanocluster formation and function. Mol Cell Biol, 28, 4377-4385.
  • Robertson J, Wu J, Arends J, Zhou C, Adrogue HE, Chan JT, Lou Y (2008) Spontaneous recovery from early glomerulus inflammation is associated with resistance to anti-GBM glomerulonephritis: tolerance and autoimmune tissue injury.  J Autoimmun, 30, 246-256.
  • Rowlinson SW, Yoshizato H, Barclay JL, Brooks AJ, Behncken SN, Kerr LM, Millard K, Palethorpe K, Nielsen K, Clyde-Smith J, Hancock JF and Waters MJ. (2008). An agonist-induced conformational change in the Growth Hormone receptor determines choice of signaling pathway. Nature Cell Biol, 10, 740-747.
  • Schonbrunn A (2008). Selective agonism in somatostatin receptor signaling and regulation. Mol Cell Endocrin 286, 35-39.
  • Seifert Jr, WE, Actor JK, Bick RJ, Cleary LJ, Cox R, Dafny N, Felleman D, Johansson W-S, Green E, Ownby AR, Weisbrodt N, Oakes J (2008) Clinical applications: Problem solving and integration of basic science concepts using team-based learning. J Int Ass Med Sci Educ, 18-1S, 4.
  • Shalom-Feuerstein R, Plowman SJ, Rotblat B, Ariotti N, Tian T, Hancock JF and Kloog Y. (2008). K-Ras nanoclustering is subverted by over-expression of the scaffold protein galectin-3. Cancer Res, 68, 6608-6616.
  • Sharina IG, Bogatenkova EP, Thomas A, Martin E and Murad F (2008) Alpha 1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity. J Biol Chem, 283,15104-15113.
  • Toy EC, Rosenfeld GC, Loose DS and Briscoe D (2008) Case Files: Pharmacology. McGraw-Hill (Lange, 2nd edition), New York.
  • Van Hees HWH, Li Y-P, Ottenheijm CAC, Jin B, Pigmans CJC, Linkels M, Dekhuijzen PNR and Heunks LMA (2008).  Proteasome inhibition improves diaphragm function in congestive heart failure rats.  Am J Physiol Lung Cell Mol Physiol, 294, 1260-1268.
  • Wilkins SJ, Yoong S, Verkade H, Mizoguchi T, Plowman SJ, Hancock JF, Kikuchi Y, Heath JK and Perkins A. (2008). Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation. Dev Biol, 314, 12-22.
  • Wu J, Bonsra AN and Du G (2008) pSM155 and pSM30 vectors for miRNA and shRNA expression. In siRNA and miRNA Gene Silencing, M. Sioud, ed. (New York, Humana Press), pp. 205-219.
  • Wu X, Carr HS, Dan I, Ruvolo PP and Frost JA (2008) p21 activated kinase 5 activates Raf-1 and targets it to mitochondria. J Cell Biochem, 105, 167-175.
  • Xin W, Tran TM, Richter W, Clark RB and Rich TC (2008) Roles of GRK and PDE4 Activities in the Regulation of b2 Adrenergic Signaling. J Gen Physiol. 131, 349-364
  • Yang JS, Gad H, Lee SY, Mironov A, Zhang L, Beznoussenko GV, Valente C, Turacchio G, Bonsra AN, Du G, et al (2008) A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance. Nature Cell Biol, 10, 1146-1153.
  • Zayat M, Lichtenberger LM and Dial EJ (2008) Pathophysiology of lipopolysaccharide induced gastrointestinal injury in the rat: Role of secretory phospholipase A2. Shock, 30, 206-211.
  • Zhu H, Wei X, Bian K and Murad F (2008) Effect of nitric oxide on skin burn wound healing. J Burn Care Res.  29, 804-814.