2015 Publications

• Almahariq M, Chao C, Mei FC, Hellmich MR, Patrikeev I, Motamedi M, and Cheng X. (2015). Pharmacological Inhibition and Genetic Knockdown of EPAC1 Reduce Pancreatic Cancer Metastasis in vivo. Mol Pharma, 87:142-149. [Faculty1000 recommended paper] http://f1000.com/prime/725232154
• Almahariq M, Mei FC, Wang H, Cao AT, Yao S, Soong L, Sun J, Cong Y, Chen J, and Cheng X. (2015). Exchange Protein Directly Activated by cAMP (EPAC1) Modulates Regulatory T Cell-Mediated Immune Suppression. Biochem J, 465:295-303.
• Banerjee U, Cheng X. (2015). Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics. Gene. Oct 10;570(2):157-67. doi: 10.1016/j.gene.2015.06.063. Epub 2015 Jun 26.
• Beck-García K, Beck-García E, Bohler S, Zorzin C, Sezgin E, Levental I, Alarcón B, Schamel WW. (2015). Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains. Biochim Biophys Acta., 1853, 802-9.
• Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW. (2015) Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiples Interaction Sites. Mol Pharmacol. Oct;88(4):758-67. doi: 10.1124/mol.115.099556. Epub 2015 Jul 23.
• Chen JA, Splenser A, Guillory B, Luo J, Mendiratta M, Belinova B, Halder T, Zhang G, Li Y-P, Garcia JM. (2015).  Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved. J Cachexia Sarcopenia Muscle, Jun;6(2):132-43.
• Cho KJ, van der Hoeven D, Zhou Y, Maekawa M, Ma X, Chen W, Fairn GD and Hancock JF. (2015). Inhibition of acid sphingomyelinase by fendiline depletes cellular phosphatidylserine and mis-localizes K-Ras from the plasma membrane. Mol Cell Biol., Nov 16. pii: MCB.00719-15. [Epub ahead of print].
• Dial EJ, Dawson PA, Lichtenberger LM. (2015) In vitro evidence that phosphatidylcholine protects against indomethacin/bile acid-induced injury to cell. Am J Physiol Gastrointest Liver Physiol. Feb 1;308(3):G217-22. doi: 10.1152/ajpgi.00322.2014. Epub 2014 Dec 4.
• Freudenberg U, Zieris A, Chwalek K, Tsurkan MV, Maitz MF, Atallah P, Levental KR, Eming SA, Werner C.  (2015).  Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds. J Control Release.  Dec 28;220(Pt A):79-88. doi: 10.1016/j.jconrel.2015.10.028. Epub 2015 Oct 22.
• Ganesan L, Levental I. (2015). Pharmacological Inhibition of Protein Lipidation. J Membr Biol. Dec;248(6):929-41. doi: 10.1007/s00232-015-9835-4. Epub 2015 Aug 18.
• Hoover RS, Tomilin V, Hanson LN, Pochynyuk O, Ko B. (2015). PTH Modulation of NCC Activity Regulates TRPV5 Calcium Reabsorption. Am J Physiol Renal Physiol. Nov 25: [Epub ahead of print].
• Ihida-Stansbury K, Ames J, Chokshi M, Aiad N, Sanyal S, Kawabata KC, Levental I, Sundararaghavan HG, Burdick JA, Janmey P, Miyazono K, Wells RG, Jones PL. (2015). Role played by Prx1-dependent extracellular matrix properties in vascular smooth muscle development in embryonic lungs.  Pulm Circ., Jun;5(2):382-97. doi: 10.1086/681272.
• Li Z, Gorfe AA. (2015). Receptor-mediated membrane adhesion of lipid–polymer hybrid (LPH) nanoparticles studied by dissipative particle dynamics simulations. Nanoscale. Jan 14;7(2):814-24. doi: 10.1039/c4nr04834b.
• Lichtenberger LM, Bhattari D, Phan TM, Dial EJ, Uray K. (2015). Suppression of contractile activity in the small intestine by indomethacin and omeprazole.  Amer J Physiol Gastrointest Liver Physiol., May 1;308(9):G785-93. doi: 10.1152/ajpgi.00458.2014. Epub 2015 Feb 26.
• Lin X, Li Z, Gorfe AA. (2015). Reversibility of the effects of peptide concentration and lipid composition on the clustering of H-Ras lipid anchors. Biophys J, In Press.
• Lorent JH, Levental I. (2015). Structural determinants of protein partitioning into ordered membrane domains and lipid rafts. Chem Phys Lipids., Aug 1. pii: S0009-3084(15)30027-X. doi: 10.1016/j.chemphyslip.2015.07.022. [Epub ahead of print].
• Mamenko M, Dhande I, Tomilin V, Zaika O, Boukelmoune N, Zhu Y, Gonzalez-Garay ML, Pochynyuk O, Doris PA. (2015). Defective Store-Operated Calcium Entry Causes Partial Nephrogenic Diabetes Insipidus. J Am Soc Nephrol., Nov 16. pii: ASN.2014121200. [Epub ahead of print].
• Mamenko M, Zaika O, Boukelmoune N, O’Neil RG, and O Pochynyuk. (2015). Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron. Am J Physiol Renal Physiol., 308(4):F275-86. doi: 10.1152/ajprenal.00485.2014. Epub 2014 Dec 10.
• McCarthy M, Prakash P, Gorfe AA. (2015). Computational Allosteric Ligand Binding Site Identification on Ras Proteins. Acta Biochim Biophys Sin (Shanghai)., Oct 19. pii: gmv100. [Epub ahead of print].
• Najumudeen AK, Posada IMD, Lectez B, Zhou Y, Landor S, Fallarero A, Vuorela P, Hancock JF, Abankwa D. (2015). Phenotypic screening identifies protein synthesis inhibitors as H-ras nanocluster dependent tumor growth inducers. Biochemistry., Nov 30. [Epub ahead of print]
• Pavlov TS, Ilatovskaya DV, Palygin O, Levchenko V, Pochynyuk O, Staruschenko A. (2015). Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium. J Vis Exp. Sep 1;(103). doi: 10.3791/53035.
• Piktel E, Niemirowicz K, Wnorowska U, Wątek M, Wollny T, Głuszek K, Góźdź S, Levental I, Bucki R. (2015). The Role of Cathelicidin LL-37 in Cancer Development. Arch Immunol Ther Exp (Warsz). Sep 22. [Epub ahead of print]
• Prakash P, Hancock JF, Gorfe AA. (2015). Binding hotspots on K-Ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis. Proteins., May;83(5):898-909. doi: 10.1002/prot.24786. Epub 2015 Mar 25
• Prakash P, Sayyed-Ahmad A, Gorfe AA. (2015). pMD-membrane: A method for the identification of ligand binding sites on membrane-bound proteins. PLoS Comput Biol., Oct 27;11(10):e1004469. doi: 10.1371/journal.pcbi.1004469. eCollection 2015.
• Prakash P, Zhou Y, Liang H, Hancock JF, Gorfe AA. (2015). Oncogenic K-Ras on membrane: Stick, Swing and Rock. Submitted.
• Sarkar TR, Battula VL, Werden SJ, Vijay GV, Ramirez-Péna EQ, Rodriguez-Canales J, Taube JH, Sphyris N, Chang JT, Miura N, Porter W, Andreeff M, Mani SA. (2015). GD3 synthase regulates EMT and metastasis in breast cancer. Oncogene, 34, 2958–2967; doi:10.1038/onc.2014.245.
• Schonbrunn A. (2015). Invited Editorial:  Reproducibility in Research: A Cautionary Tale and Lessons Not Learned. Molecular Endocrinology, 29(9):1219-1221.
• Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG. (2015). Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion. Mol Endocrinol., Jul;29(7):988-1005. doi: 10.1210/me.2014-1330. Epub 2015 Jun 10.
• Solman S, Ligabue A, Blazevits O, Jaiswal A, Zhou Y, Liang H, Lectez B, Kopra K, Guzman C, Harma H, Hancock JF, Aittokallio T and Abankwa D. (2015). Specific cancer associated mutations in the switch III-region of Ras increase tumorigenicity by nanocluster augmentation. Elife., Aug 14;4. doi: 10.7554/eLife.08905.
• Song EH, Oh W, Ulu A, Carr HS, Zuo Y, Frost JA. (2015). Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity. J Cell Sci., Mar 1;128(5):913-22. doi: 10.1242/jcs.158121. Epub 2015 Jan 14.
• Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena G, Hu X, Vallien C, Kingsley C, Lu Y, Hancock JF, Liu J, Gladden A, Mills G, Lopez-Berestein G, Hung MC, Sood A, Bogdanov M and Ladbury J. (2015). Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene., Jul 27. doi: 10.1038/onc.2015.279. [Epub ahead of print].
• Tomilin V, Mamenko M, Zaika O, Pochynyuk O. (2015). Role of renal TRP channels in physiology and pathology. Semin Immunopathol., Sep 18. [Epub ahead of print].
• Wong CO, Palmieri M, Li J, Akhmedov D, Chao Y, Broadhead GT, Zhu MX, Berdeaux R, Collins CA, Sardiello M, and Venkatachalam K. (2015). Diminished MTORC1-Dependent JNK-Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Cell Rep., Sep 29;12(12):2009-20. doi: 10.1016/j.celrep.2015.08.047. Epub 2015 Sep 17.
• Wolfe AR, Debeb BG, Lacerda L, Larson R, Bambhroliya A, Huang X, Bertucci F, Finetti P, Birnbaum D, Van Laere S, Diagaradjan P, Ruffell B, Trenton NJ, Chu K, Hittelman W, Diehl M, Levental I, Ueno NT, Woodward WA. (2015). Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a. Breast Cancer Res Treat., Dec;154(3):495-508. doi: 10.1007/s10549-015-3645-3. Epub 2015 Nov 21.
• Wu HC, Yamankurt G, Luo J, Subramaniam J, Hashmi SS, Hu H, Cunha SR. (2015). Identification and characterization of two ankyrin-B isoforms in mammalian heart. Cardiovasc Res., Sep 1;107(4):466-77. doi: 10.1093/cvr/cvv184. Epub 2015 Jun 24.
• Xie K, Masuho I, Shih CC, Cao Y, Sasaki K, Lai CW, Han PL, Ueda H, Dessauer CW, Ehrlich ME, Xu B, Willardson BM, Martemyanov KA. (2015). Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. Elife., Nov 27;4. pii: e10451. doi: 10.7554/eLife.10451.
• Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy-Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW, Dascal N. (2015). A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ. PLoS Comput Biol., Nov 6;11(11):e1004598. doi: 10.1371/journal.pcbi.1004598. eCollection 2015.
• Yamankurt G, Wu HC, McCarthy M, Cunha SR. (2015). Exon organization and novel alternative splicing of Ank3 in mouse heart. PLoS One., May 29;10(5):e0128177. doi: 10.1371/journal.pone.0128177. eCollection 2015.
• Ye N, Zhu Y, Chen H, Liu Z, Mei FC, Wild C, Chen H, Cheng X, Zhou J. (2015). Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N’-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists. J Med Chem, Aug 13;58(15):6033-47. doi: 10.1021/acs.jmedchem.5b00635. Epub 2015 Jul 16.
• Zaika O, Palygin O, Tomilin V, Mamenko M, Staruschenko A, Pochynyuk O. (2015). Insulin and IGF-1 activate Kir4.1/5.1 channels in cortical collecting duct principal cells to control basolateral membrane voltage. Am J Physiol Renal Physiol., Dec 2:ajprenal.00436.2015. doi: 10.1152/ajprenal.00436.2015. [Epub ahead of print].
• Zhou Y, Hancock JF. (2015). Ras nanoclusters: versatile lipid-based signaling. Biochim Biophys Acta., Apr;1853(4):841-9. doi: 10.1016/j.bbamcr.2014.09.008. Epub 2014 Sep 16.
• Zhou Y, Wong CO, Cho KJ, van der Hoeven D, Liang H, Thakur DP, Luo J, Babic M, Zinsmaier KE, Zhu MX, Hu H, Venkatachalam K and Hancock JF. (2015). Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. Science. Aug 21;349(6250):873-6. doi: 10.1126/science.aaa5619.
• Zhu Y, Chen H, Boulton S, Mei F, Ye N, Melacini G, Zhou J*, and Cheng X*. (2015). Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window.” Scientific Reports, 5:9344.