2016 Publications

  • Akhmedov D, Rajendran K, Medonza-Rodriguez M, and Berdeaux R. (2016). Knock-in luciferase reporter mice for in vivo monitoring of CREB activity. PLoS ONE, 11(6):e0158274.
  • Armstrong TS, Shade MY, Breton G, Gilbert MR, Mahajan A, Scheurer M, Vera E, Berger AM. (2016). Sleep-wake disturbance in patients with brain tumors. Neuro-oncology. 0, 1-13, doi:10.1093/neuron/now119.
  • Baameur F, Singhmar P, Zhou YHancock JFCheng X, Heijnen C, and Kavelaars A.  (2016).  Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.  Sci Rep.  6:36370 PMCID: PMC5093460.
  • Bavencoffe A, Li Y, Wu Z, Yang Q, Herrera J, Kennedy EJ, Walters ET, Dessauer CW.  (2016).  Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation. J Neurosci., Feb 3;36(5):1660-8. doi: 10.1523/JNEUROSCI.0895-15.
  • Breton G, Kay SA, Pruneda-Paz JL.  (2016).  Identification of Arabidopsis transcriptional regulators by yeast one-hybrid screens using a transcription factor ORFeome. Environmental Responses in Plants.  Methods Mol Bio. 1398, 107-118.
  • Cai M, He J, Xiong J, Tay LWR, Wang Z, Rog C, Wang, J, Xie Y, Wang G, Banno Y, Li F, Zhu MDu G. (2016). Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells. Cell Death & Disease7(11):e2448.
  • Chen CY, Chang JT, Ho YF, Shyu AB. (2016).  MiR-26 dampens IL-6 production by down-regulating the TNF-a/NF-kB signaling through silencing HMGA1 and MALT1 and not by directly targeting IL-6 mRNA.  NAR.  44(8), 3772-87.
  • Christopher C, Zhu Y, Ye N, Mei F, Ynalvez M, Chen H, Cheng X* and Zhou J*. (2016). Functionalized N,N-Biarylamines as Potent and Selective EPAC2 Inhibitors. ACS Medicinal Chemistry Letters, 7:460-464.
  • Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SRGorfe AAHancock JF. (2016). AMPK and eNOS signaling regulates K-Ras plasma membrane interactions via cGMP-dependent Protein Kinase 2. Mol Cell Biol. 36, 3086-3099.
  • Dhande I, Zhu Y, Braun MC, Hicks MJ, Wenderfer SE, Doris PA.  (2016)._Mycophenolate Mofetil Prevents Cerebrovascular Injury in Stroke-prone Spontaneously Hypertensive Rats. Physiol Genom. PMID 28011882.
  • Ding H, Zhang G, Sin KWT, Liu Z, Lin R-K, Li M and Li Y-P. (2016). Activin A induces skeletal muscle catabolism via p38β mitogen-activated protein kinase. J Cachexia Sarcopenia Muscle, DOI: 10.1002/jcsm.12145.
  • Gao L, Yang P, Qin P, Lu Y, Li X, Tian Q, Li Y, Xie C, Tian JB, Zhang C, Tian C, Zhu MX, Yao J. (2016).  Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid. Sci Rep, Feb 15;6:20791. doi: 10.1038/srep20791.
  • Gingold J, Zhou R, Lemischka IR, Lee DF.  (2016).  Modeling cancer with pluripotent stem cells. Trends Cancer. 2(9):485-494.
  • Hoover RS, Tomilin V, Hanson LN, Pochynyuk O, and Ko B.  (2016).  PTH Modulation of NCC Activity Regulates TRPV5 Calcium Reabsorption.  Am J Physiol Renal Physiol. 310(2): F144-51.
  • Hu X, Adebiy MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko MPochynyuk O, Kellems RE, Etslzchig HK, Blackburn MR, Walters ET, Huang D, Hu H, and Xia Y.  (2016).  Sustained elevation of adenosine-ADORA2B signaling promotes chronic pain through neuroimmune interaction. Cell Rep. 16(1):106-19.
  • Hu Y, Robichaux WG, Kim ER, Mei FC, Wang H, Tong Q, Xu M, Chen J, and Cheng X. (2016). Role of exchange protein directly activated by cAMP isoform 1 in energy homeostasis: regulation of leptin expression and secretion in white adipose tissue. Mol Cell Biology, 36:2440-1250. [MCB Spotlight article]
  • Jaber N, Mohd-Naim N, Wang Z, DeLeon JL, Kim S, Zhong H, Sheshadri B, Dou Z, Edinger AL, Du G, Braga VMM, and Zong WX. (2016). Class III PI 3-kinase Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase activating protein Armus. J. Cell. Sci. 129(23):4424-4435.
  • Jansen, S, Poppinga, W, de Jager, W, Lezoualc’h, F, Cheng, X, Wieland, T, Yarwood, S, Gosens, R, and Schmidt, M. (2016).  Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition. Oncotarget. 7:46354-46370.
  • Jeon JP, Thakur DP, Tian JB, So I, Zhu MX.  (2016).  Regulator of G protein signaling and GoLoco proteins suppress TRPC4 channel function via acting at Galphai/o. Biochem J. 473, 1379-1390.
  • Jiang Y, Sverdlov MS, Toth PT, Huang L, Du G, Liu Y, Natarajan V, Minshall RD. (2016). Phosphatidic acid produced by RalA-activated PLD2 stimulates caveolae-mediated endocytosis and trafficking in endothelial cells. J Biol Chem. 291(39):20729-38.
  • Lee DF, Walsh MJ, Aguilo F.  (2016).  ZNF217/ZFP217 meets chromatin and RNA. Trends Biochem Sci. 41(12):986-988.
  • Levental KR, Lorent JH, Lin X, Skinkle AD, Surma MA, Stockenbojer EA, Gorfe AALevental I. (2016). Polyunsaturated lipids regulate membrane domain stability by tuning membrane order.  Biophys J. 110, 1800-1810.
  • Li Y, Hu H, Butterworth MB, Tian JBZhu MXO’Neil RG. (2016). Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney. PLoS One. 11(5):e0155006.
  • Liao, G, Gao, B, Gao, Y, Yang, X, Cheng, X, and Ou Y.  (2016).  Phycocyanin inhibits tumorigenic potential of pancreatic cancer cells: role of apoptosis and autophagy. Scientific Report. 6:34564.
  • Lin X, Lorent JH, Skinkle AD, Levental KR, Waxham MN, Gorfe AALevental I. (2016). Domain Stability in Biomimetic Membranes Driven by Lipid Polyunsaturation. J Phys Chem B. 120, 11930-11941.
  • Lin X, Zhang S, Ding H, Levental I and Gorfe AA. (2016). The Aliphatic Chain of Cholesterol Modulates Bilayer Interleaflet Coupling and Domain Registration.  FEBS Lett.  590, 3368–3374.
  • Lu G, Chang JT, Liu Z, Li M, Chen Y, Zhu JJ.  (2016).  Phospholipase C Beta1 Is A Potential Signature Gene for Proneural Subtype Glioma and Its Expression Level Correlates with Patients’ Survival.  Mol Neurobiology.  53(9), 6511-6525.
  • Lu M, Tay LWR, He J, Du G. (2016). Monitoring Phospholipid Signaling in Breast Cancer Cells Using Genetically Encoded Biosensors. Methods Mol Biol, 1406:225-37. doi: 10.1007/978-1-4939-3444-7_20.
  • Mamenko M, Dhande I, Tomilin V, Zaika O, Boukelmoune N, Zhu Y, Gonzalez-Garay ML, O Pochynyuk, and PA Doris. (2016). Defective store-operated calcium entry causes partial nephrogenic diabetes insipidus. J Amer Soc Nephrol. 27(7):2035-48.
  • Mansouri S, Singh S, Alamsahebpour A, Burrell K, Li M, Karabork M, Ekinci C, Solaroglu I, Chang J, Aldape K, Zadeh G.  (2016).  DICER Governs Characteristics of Glioma Stem Cells and the Resulting Tumors in Xenograft Mouse Models of GBM.  Oncotarget.  7(35), 56431-56446.
  • Mistry A, Wynne B, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli A, Ko B, Mattheyses A, Bao H-F, Pochynyuk O, Theilig F, Eaton D, and Hoover R.  (2016).  The Sodium Chloride Cotransporter (NCC) and Epithelial Sodium Channel (ENaC) Associate.  Biochem J. 473(19):3237-52.
  • Nixon M, Stewart-Fitzgibbon R, Fu J, Akhmedov D, Rajendran K, Mendoza-Rodriguez MG, Rivera-Molina M, Gibson M, Berglund ED, Justice NJ and Berdeaux R. (2016). Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesityMolecular Metabolism, 5(1): 34-46.
  • Nowak M, Freudenberg U, Tsurkan MV, Werner C, Levental KR. (2016) Modular GAG-matrices to promote mammary epithelial morphogenesis in vitro. Biomaterials 112:20-30.
  • Palygin O, Pochynyuk O and Staruschenko A.  (2016).  Role and mechanisms of regulation of the basolateral Kir4.1/Kir5.1 K+ channels in the distal tubules.  Acta Physiologica.  219(1):260-273.
  • Paranjape AN, Soundararajan R, Werden SJ, Joseph R, Taube JH, Liu H, Rodriguez-Canales J, Sphyris N, Wistuba I, Dhillon J, Mahajan N, Mahajan K, Chang JT, Ittmann M, Maity SN, Logothetis C, Miura N, Tang DG, Mani SA.  (2016).  Inhibition of FOXC2 restores epithelial phenotype and drug-sensitivity in prostate cancer cells with stem-like properties. Oncogene. 35(46), 5963-5976.
  • Posada IM, Zhou Y, Lectez B and Abankwa D. (2016).  ASPP2 is a Novel Pan-Ras Nanocluster Scaffold.  PLoS ONE. e0159677. PMCID: PMC4954646.
  • Prakash P and Gorfe AA. (2016). Membrane orientation dynamics of lipid-modified small GTPases, Small GTPases. 11, 1-10.
  • Prakash P, Sayyed-Ahmad A, Cho K-J, Dolino DM, Chen W, Li H, Grant BJ, Hancock JFGorfe AA.  (2017). Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers. Sc Rep. 7, 40109.
  • Prakash P, Zhou Y, Liang H, Hancock JF and Gorfe AA. (2016). Oncogenic K-Ras binds to an anionic membrane in two distinct orientations: A molecular dynamics analysis, Biophys J. 110, 1125–1138.
  • Sayyed-Ahmad A, Cho K-J, Hancock JF and Gorfe AA. (2016).  Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggest Limited Functional Role. J Phys Chem B. 120, 8547-8556.
  • Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor Jr, F, Murga C, Heijnen CJ, and Kavelaars A. (2016). A critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Acad Natl Sci USA, 113:3036-3041.
  • Spencer-Smith R, Koide A, Zhou Y, Eguchi R, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoieh H, Smith M, Rajakulendran T, Dowdell E, Okur NF, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O’Bryan JP.  (2016).  Inhibition of Ras function through targeting an allosteric regulatory site.  Nat Chem Biol.  PMCID: PMC5193369.
  • Tang X, Wu J, Ding CK, Sjol J, Lu M, Lin CA, Keenan M, Lin CC, Wang CC, Wardell S, George D, McDonnell DP, Hsu DS, Chang JT, Chi, JT.  (2016).  Cell-type specific cystine addiction associated with distinct signaling amplification of programmed necrosis. Oncogene.
  • Thakur DP, Tian J, Jeon J, Xiong J, Huang Y, Flockerzi V, Zhu MX. (2016). Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels. Proc Natl Acad Sci U S A,  Jan 26;113(4):1092-7. doi: 10.1073/pnas.1522294113. Epub 2016 Jan 11.
  • Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena G, Hu X, Vallien C, Kingsley C, Lu Y, Hancock JF, Liu J, Gladden A, Mills G, Lopez-Berestein G, Hung MC, Sood A, Bogdanov M, and Ladbury J. (2016).  Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.  Oncogene.  Apr 28;35(17):2186-96. doi: 10.1038/onc.2015.279.  PMCID: PMC4792786
  • Tisza MJ, Sjol JS, Chen X, Levental I*, Chang JT*.  (2016).  Motility and stem cell properties induced by the Epithelial-Mesenchymal Transition require destabilization of lipid rafts.  Oncotarget. 7(32), 51553-51568.  * Co-Corresponding Authors.
  • Tsai WB, Long Y, Park JR, Chang JT, Liu H, Rodriguez-Canales J, Savaraj N, Feun LG, Davies MA, Wistuba II, Kuo MT. (2016). Gas6/Axl is the sensor of Arginine-Auxotrophic Response in Targeted Chemotherapy with Arginine-Depleting Agents. Oncogene. 35(13), 1632-42.
  • Tulodziecka K, Diaz-Rohrer BB, Farley MM, Chan RB, Di Paolo G, Levental KR, Waxham MN, Levental I. (2016). Remodeling of the postsynaptic plasma membrane during neural development.  Mol Biol Cell. 27(22):3480-3489.
  • Ulu A & Frost JA. (2016). Regulation of RhoA activation and cytoskeletal organization by acetylation. Small
    GTPases
    ., Apr 2;7(2):76-81. doi: 10.1080/21541248.2016.1171283. Epub Apr 12.
  • Wang H, Robichaux W, Wang Z, Mei F, Cai M, Du G, Chen J, and Cheng X. (2016). Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury. Sci Rep. 6:36552.
  • Wang Z, Liang X, Cai M, Du G.  (2016).  Analysis of Invadopodia Formation in Breast Cancer Cells.  Methods Mol Biol. 1406:203-10. doi: 10.1007/978-1-4939-3444-7_18.
  • Werden SJ, Sphyris N, Sarkar TR, Paranjape AN, LaBaff AM, Taube JH, Hollier BG, Ramirez-Peña EQ, Soundararajan R, Den Hollander P, Powell E, Echeverria G, Miura N, Chang JT, Piwnica-Worms H, Rosen JM, Mani SA.  (2016).  Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth.  Oncogene. 35(46), 5977-5988.
  • Xu Y, Myers MG, Chang JT, Xu Y, Tong Q. (2016). Euglycemia restoration by central leptin in type 1 diabetes requires STAT3 signaling but not fast-acting neurotransmitter release. Diabetes. 65(4), 1040-9.
  • Zaika O, Palygin O, Tomilin V, Mamenko M, Staruschenko A, Pochynyuk O. (2016).  Insulin and IGF-1 activate Kir4.1/5.1 channels in cortical collecting duct principal cells to control basolateral membrane voltage.  Am J Physiol Renal Physiol. 310(4): F311-21.
  • Zaika O, Tomilin V, Mamenko M, Bhalla V, Pochynyuk O.  (2016).  New Perspective of ClC-Kb/2 Chloride Channel Physiology in the Distal Renal Tubule.  Am J Physiol Renal Physiol. 310(10): F923-30.
  • Zhang G, Liu Z, Ding H, Miao H, Garcia JM, Li YP.  (2017).  Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways. Sci Rep. May 23;7(1):2273. doi: 10.1038/s41598-017-02347-2.
  • Zhao W, Prijic S, Urban B, Tisza MJ, Li L, Tan Z, Chen X, Mani SA, Chang JT. (2016). Candidate anti-metastasis drugs suppress the metastatic capacity of breast cancer cells by reducing membrane fluidity. Cancer Research. 76(7), 2037-49.
  • Zhou M, Wiener H, Su W, Zhou Y, Liot C, Ahearn I, Hancock JF and Philips MR.  (2016).  VPS35 Binds Farnesylated N-Ras in Cytosol to Regulate N-Ras Trafficking.  J Cell Biol. 214(4): 445-58. PMCID: PMC498729.
  • Zhou Y, Prakash P, Liang H, Gorfe AA and Hancock JF.  (2016).  Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output.  Cell. 168 (1-2): 239-251 PubMed PMID: 28041850 (PMCID in progress).
  • Zuo Y, Oh W, Ulu A, Frost JA. (2016).  Mini-review: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis. Mol Endocrinol, Mar;30(3):278-89. doi: 10.1210/me.2015-1294. Epub 2015 Dec 17.