Biography

Dr. Vijay Govindarajan obtained his bachelor’s degree in mechanical engineering from the College of Engineering, University of Kerala, India and his PhD in Biomedical engineering from the University of Iowa, Iowa City, respectively. His research interests are in the application of fluid and solid mechanical principles towards understanding and solving clinically relevant cardiovascular problems working closely with cardiologists, surgeons, and other biomedical engineers. Dr. Govindarajan has developed computational and experimental models using computational fluid dynamics, finite element methods, fluid-structure interaction, transport phenomenon and biochemical kinetics, in-vitro pulse duplicator systems and microfluidics geared toward gaining clinical insights into heart valve dynamics, vascular mechanics, and clotting dynamics.

Education

Doctoral Degree
Biomedical Engineering from the University of Iowa

Areas of Interests

Clinical Interests

  • Computational Modeling
  • Heart Valve Dynamics
  • Virtual Surgeries
  • Vascular Fluid Dynamics
  • Clotting Dynamics

Publications

Publication Information

  • SP Grover, PK Bendapudi, M. Yang, G. Merrill-Skoloff, Govindarajan, A.Y. Mitrophanov, R. Flaumenhaft. Injury measurements improve interpretation of thrombus formation data in the cremaster arteriole laser-induced injury model of thrombosis. J Thromb Haemost.
    2020 Nov;18(11):3078-3085.  Epub 2020 Oct 29. [PMID 33456401]. 
  • Y. Mitrophanov,G. Merrill-Skoloff, S. Grover, V. Govindarajan, A. Kolanjiyil, D. Hariprasad, G. Unnikrishnan, R. Flaumenhaft, and J. Reifman. Injury Length and Arteriole Constriction Shape Clot Growth and Blood-Flow Acceleration in a Mouse Model of Thrombosis. Arteriosclerosis Thromb Vasc Biol. 2020 Sep;40(9):2114-2126. Epub 2020 Jul 9. [PMID 32640902]. 
  • Y. Mitrophanov, Govindarajan, V., S. Zhu, R. Li, Y. Lu, S. L. Diamond, and J. Reifman. Microfluidic and computational study of structural properties and resistance to flow of blood clots under arterial shear. Biomechanics Model Meccanobiol. (2019): 1-14.[PMID: 31055691]
  • Govindarajan V., Mousel J., Udaykumar H.S., Vigmostad S.C., McPherson D.D., Kim H., and Chandran K.B., 2018 Synergy between Diastolic Mitral Valve Function and Left Ventricular Flow Aids in Valve Closure and Blood Transport during Systole. Sci Rep., 8(1), 6187. [PMID 29670148]
  • Govindarajan, V., Zhu, S., Li, R., Lu, Y., Diamond, S.L., Reifman, J. and Mitrophanov, A.Y., 2018. Impact of Tissue Factor Localization on Blood Clot Structure and Resistance under Venous Shear. Biophysical Journal, 114(4), pp.978-991. [PMID 2490257].
  • Govindarajan, V., Rakesh, V., Reifman, J. and Mitrophanov, A.Y., 2016. Computational study of thrombus formation and clotting factor effects under venous flow conditions. Biophysical journal, 110(8), pp.1869-1885.
  • Vijay Govindarajan., Three-dimensional Fluid Structural Interaction of Tissue Valves. PhD Thesis, University of Iowa. May 2013.
  • Govindarajan., H.S. Udaykumar., L. H. Herbertson., S. Deutsch., K. B. Manning., K.B. Chandran., 2010, Two-dimensional FSI simulation of closing dynamics of a tilting disc mechanical heart valve, J. Med devices, V. 4, Issue 1, 011001, 11 pages.
  • Govindarajan., H. S. Udaykumar., L. H. Herbertson., S. Deutsch., K. B. Manning., K. B. Chandran., 2009, Impact of Design Parameters on Bileaflet Mechanical Heart Valve Flow Dynamics. The Journal of Heart Valve Disease, v.18, p. 535-545.
  • Govindarajan., H. S. Udaykumar., K. B. Chandran., 2009, Flow dynamic comparison between recessed hinge and open pivot bi-leaflet heart valve designs. Journal of Mechanics in Medicine and Biology, v.9, Issue: 2, p. 161-176.
  • Govindarajan., H. S. Udaykumar., K. B. Chandran., 2009, Two-Dimensional Simulation of Flow and Platelet Dynamics in the Hinge Region of a Mechanical Heart Valve, J. Biomech. Eng, v.131, Issue 03, 1002, 12 pages. (Top 10 Most Downloaded Articles — February 2009)