Assistant Professor-Research, Department of Microbiology and Molecular Genetics
Education & Training
- Postdoctoral Fellow
- University of Texas Health Science Center, Houston, 2005
- The University of Glasgow, UK, 1990
My Ph.D. research was on the light-harvesting antenna complexes of photosynthetic bacteria. This work was jointly supervised by Richard Cogdell and Kim Kaiser in the UK. After a short postdoctoral fellowship, which involved isolating genes involved in Drosophila behavior, I moved to the US and returned to working with photosynthetic bacteria. This work was carried out in the lab of Samuel Kaplan in this department. Our work was among the early genome projects and focused on sequencing Rhodobacter sphaeroides 2.4.1 and using bioinformatics to examine novel regulatory pathways in this organism. My current research focuses on the possible link between Streptococcus gallolyticus and colon cancer, a project I share with my spouse, Yi Xu at Texas A&M.
My current research interests lie with the possible connection between Streptococcus gallolyticus and colon cancer and how bioinformatic methods may be used to guide experimental approaches in the lab.
In terms of teaching; I am the course director for the courses Medical Microbiology and Clinical Applications both of which are taught to first year medical students. I am also a facilitator for Problem Based Learning (PBL) for second year students.
Barbu E.M., Vannakambadi, K.G., Shivasankarappa, G., Mackenzie, C., Foster, T.J., Sudhof, T.C. and Hook, M. β-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC. PLoS Pathogens. 6(1):e1000726. (2010).
Mackenzie, C., Eraso, J. M., Choudhary, M., Roh, J. H., Zeng, X., Bruscella, P., Puskas, A., Kaplan, S. Postgenomic adventures with Rhodobacter sphaeroides Annu. Rev. Microbiol. 61: 283-307. (2007).
Goldman BS, Nierman WC, Kaiser D, Slater SC, Durkin AS, Eisen JA, Ronning CM, Barbazuk WB, Blanchard M, Field C, Halling C, Hinkle G, Iartchuk O, Kim HS, Mackenzie C, Madupu R, Miller N, Shvartsbeyn A, Sullivan SA, Vaudin M, Wiegand R, Kaplan HB. Evolution of sensory complexity recorded in a myxobacterial genome. Proc. Natl. Acad. Sci. USA. 103: 15200-5 (2006).
Mao L., Mackenzie C., Roh JH., Eraso J.M., Kaplan S. and Resat H. Combining microarray and genomic data to predict DNA binding motifs. Microbiology. 151: 3197-213. (2005).
Pappas C.T., Sram J., Moskvin O.V., Ivanov P.S., Mackenzie R.C., Choudhary M., Land M.L., Larimer F.W., Kaplan S., Gomelsky M. Construction and validation of the Rhodobacter sphaeroides 2.4.1 DNA microarray: transcriptome flexibility at diverse growth modes. J. Bacteriol. 186: 4748-58. (2004).