Education

Masters Degree
Advanced Studies, Master's University, Malaga, Spain
Doctorate Degree
University of Malaga, Spain
Teaching Certification
University of Malaga, Spain
Postdoctoral Training
Univesity of Texas Health Science Center at Houston

Areas of Interests

Research Interests

Risk factors for Alzheimer’s disease and related brain disorders

Research Information

Alzheimer’s disease is the most common neurodegenerative disease leading to dementia in the elderly, mostly affecting individuals over 65 years old. The deficient knowledge about Alzheimer’s etiology and the implication of risk factors in the onset and progression of the disease makes its prevention an arduous task. Our research is focused in the analysis of risk factors of Alzheimer’s disease, including smoking, consumption of meat, and comorbidity (type 2 diabetes, amyotrophic lateral sclerosis, traumatic brain injury, epilepsy and stroke). Our work includes experimental approaches using both transgenic mouse models and hippocampal slice culture. The use of multidisciplinary techniques, including animal behavior, histology, western blot, and ex vivo culture, allow us to analyze in detail the underlying mechanisms involved in Alzheimer’s pathology and how different factors exacerbate this process.

Publications

Publication Information

  1. Baglietto-Vargas D, Lopez-Tellez JF, Moreno-Gonzalez I, Gutierrez A, Aledo JC. Segregation of two glutaminase isoforms in islets of Langerhans. Biochemical Journal (2004) 381:483-487.
  2. Ramos B*, Baglietto-Vargas D*, del Rio JC*, Moreno-Gonzalez I*, Santa-Maria C, Jiménez S, Caballero C, Lopez-Tellez JF, Khan ZU, Ruano D, Gutierrez A, Vitorica J. Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer’s disease. Neurobiology of Aging (2006) 27(11):1658-72. *First authors.
  3. Caballero C, Jimenez S, Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Gavilan MP, Ramos B, Del Rio JC, Vizuete M, Gutierrez A, Ruano D, Vitorica J. Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice. Journal of Neuroscience Research (2007) 85:787-797.
  4. Gavilan MP, Revilla E, Pintado C, Castaño A, Vizuete ML, Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Vitorica J, Gutierrez A, Ruano R. Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons. Journal of Neurochemistry (2007) 103(3):984-96.
  5. Montero F, Baglietto-Vargas D, Moreno-Gonzalez I, Lopez-Tellez JF, Cuesta-Muñoz AL, Gutierrez A, Aledo JC. Glutaminase activity is confined to the mantle of the islets of Langerhans. Biochemie (2007) 89(11):1366-71.
  6. Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J. Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer’s disease: Age-dependent switch in the microglial phenotype from alternative to classic. Journal of Neuroscience (2008) 28(45):11650-61.
  7. Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, del Rio JC, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A. Extracellular Aβ and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1M146L/APP751SL mice. Journal of Alzheimer’s Disease (2009), 18(4):755-776.
  8. Baglietto-Vargas D, Moreno-Gonzalez I, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A. Calretinin interneurons are early targets of extracellular amyloid-β pathology in PS1/AbetaPP Alzheimer mice Hippocampus. Journal of Alzheimer’s Disease (2010), 21(1):119-32.
  9. Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus. Acta Neuropathologica (2012), 123(1):53-70.
  10. Moreno-Gonzalez I, Estrada L, Sanchez-Mejias E, Soto C. Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease. Nature Communications (2013), 4:1495. doi: 10.1038/ncomms2494.
  11. Duran-Aniotz C, Morales R, Moreno-Gonzalez I, Hu PP, Soto C. Brains from Non-Alzheimer’s individuals containing amyloid deposits accelerate Abeta deposition in vivo. Acta Neuropathologica Communications (2013) 1:76.
  12. Trujillo-Estrada L, Jimenez S, DeCastro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila CJ, Vizuete ML, Gutierrez A, Vitorica J. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology. Acta Neuropathologica Communications (2013) 1:73.
  13. Duran-Aniotz C, Morales R, Moreno-Gonzalez I, Hu PP, Fedynyshyn J, Soto C. Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer’s disease. PLOS ONE (2014) 9(2):e89014.
  14. Carriba P, Jimenez S, Navarro V, Moreno-Gonzalez I, Barneda-Zahonero B, Moubarak RS, Lopez-Soriano J, Gutiérrez A, Vitorica J, Comella J. Amyloid beta reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death. Cell Death Dis (2015) 6:e1639.
  15. Hu PP, Morales R, Duran-Aniotz C, Moreno-Gonzalez I, Khan U, Soto C. Role of prion replication in the strain-dependent brain regional distribution of prions. J Biol Chem. (2016) 291(24):12880-7.
  16. Moreno-Gonzalez I, Edwards III G, Salvadores N, Shahnawaz M, Diaz-Espinoza R, Soto C. Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding. Molecular Psychiatry (2017), 10.1038/mp.2016.230*. *Highlighted in Nature Reviews Neurology
  17. Misfolded diabetes-mellitus peptide seeds amyloid-β aggregation, C Ridler, Nature Reviews Neurology 13, 128 (2017) doi:10.1038/nrneurol.2017.5
  18. Park KW, Kim GE, Morales R, Moda F, Moreno-Gonzalez I, Concha-Marambio L, Lee AS, Hetz C, Soto C. The endoplasmic reticulum chaperone GRP78/BiP modulates prion propagation in vitro and in vivo. Scientific Reports (2017) 7:44723.
  19. Diaz-Espinoza R, Morales R, Concha-Marambio L, Moreno-Gonzalez I, Moda F, Soto C. Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo. Molecular Psychiatry (2017) doi: 10.1038/mp.2017.84*. *Highlighted in Nature Reviews Neurology
  20. Prion disease: ‘Anti-prions’ block prion disease onset, C Ridler, Nature Reviews Neurology (2017) doi: 10.1038/nrneurol.2017.100
  21. Carlock C, Wu J, Shim J, Moreno-Gonzalez I, Pitcher M, Hicks J, Suzuki A, Iwata J, Quevedo J, Lou Y. Interleukin33 deficiency causes Tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice. Translational Psychiatry (2017) 7(7):e1164. doi: 10.1038/tp.2017.142.
  22. Mukherjee, Morales-Scheihin D, Salvadores N, Moreno-Gonzalez I, Gonzalez C, Taylor-Presse K, Mendez N, Shahnawaz M, Gaber A, Sabek O, Fraga D, Soto C. Induction of IAPP Amyloid Deposition and Associated Diabetic Abnormalities by a Prion-like Mechanism. Journal of Experimental Medicine (2017) doi: 10.1084/jem.20161134.
  23. Review articled
  24. Moreno-Gonzalez I, Soto C. Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission. Seminars in Cell & Developmental Biology (2011), 22(5):482-7*. *Cover page
  25. Moreno-Gonzalez I, Soto C. Natural Models of Neurodegenerative Protein Misfolding Diseases. Current Pharmaceutical Design (2012), 18(8):1148-58.
  26. Duran-Aniotz C, Moreno-Gonzalez I, Morales R. Agregados amiloides: rol en Desórdenes de Conformación Proteica. Revista Médica de Chile (2013), 141: 495-505.
  27. Morales R, Moreno-Gonzalez I, Soto C. Cross-seeding of misfolded proteins: Implications for etiology and pathogenesis of protein misfolding diseases. PLOS Pathogens (2013), 9(9):e1003537.
  28. Edwards III G, Moreno-Gonzalez I, Soto C. Amyloid-beta and tau pathology following repetitive mild traumatic brain injury. Biochemical and Biophysical Research Communications (2016), 483(4):1137-1142.
  29. Dhouafli Z, Cuanalo-Contreras K, Mays C, Soto C, Moreno-Gonzalez I. Inhibition of Amyloid Aggregation by Natural Phenolic Compounds. Cellular and Molecular Life Sciences (2018)

Book Chapters

  1. Duran-Aniotz C, Morales R, Moreno-Gonzalez I, Soto C. Amyloid-β transmissibity. In Proteopathic Seeds and Neurodegenerative Diseases. M Jucker, Y Christen (Eds.) pp. 71-86. Springer (2013) New York. ISBN 978-3-642-35490-8

Books

  1. Moreno-Gonzalez I. Estudio del proceso neurodegenerativo en la corteza entorrinal del modelo transgénico PS1M146LxAPP751SL de la enfermedad de Alzheimer. Publishing service and scientific exchange (2009) Malaga. ISBN 978-84-9747-552-5