Liu Lab Profile & Members

Fudong Liu MD – Professor

Education & Training
M.S. Neuroscience, Wannan Medical College – Wuhu, China
M.D. Bengbu Medical College – Bengbu, China
Residency Neurology, Yijishan Hospital – Anhui, China

Areas of Interest
Research interests: neuroinflammation and sex differences in stroke

Research
Research interests in Dr. Liu’s lab focus on innate immune responses and sex differences in cerebral ischemia. Post-stroke inflammation is characterized as either pro- or anti-inflammatory response to neuronal damage, and significantly contributes to stroke pathology as well as functional recovery. We explore regulatory pathways underlying the neuroinflammation aiming to suppress pro-inflammatory and/or promote anti-inflammatory activation of immune cells. Stroke is a sexually dimorphic disease throughout the lifespan. We are interested in how the sex-specific stroke phenotypes are regulated in neonatal, young and aged brains. While hormonal effects play important roles in the sex difference in young stroke patients, we have found chromosomal effects in mediating the stroke sensitivity in aged brains. By using genetically modified animal models, we study X escapee genes that escape from X chromosome inactivation, and try to understand whether and how these genes impacts on the sexual dimorphism.


Shaohua Qi Ph.D. – Postdoctoral Research Fellow

Education and Training
B.S. Biology technology, Tangshan Normal University, China (2011)
M.S & Ph.D. Microbiology and Immunology College of Biological Sciences, China Agricultural University (2018)

Areas of Interests
Clinical Interest: Age associated neurodegenerative disease, ischemic stroke and neuroinflammation
Research Interest: Cerebrovascular disorder and inflammation, ischemic stroke recovery and therapeutic

Research
During my doctoral training, my project mainly focus on the fundamental research of molecular mechanism in the regulation of clock and catalase gene expression by epigenetic modification, then my interests turned on the clinical application of stroke during the post-doctoral research, especially the ischemic stroke outcome and neuroinflammation process within young and aged mouse, the microglial activation and immune responses plays an important role in the progress of age-related CNS diseases and neurotraumatic injury. Additionally, we have explored the sex chromosome genes that regulate ischemic stroke sensitivity in the aged mouse brain, We are working to explore the mechanism underlying the activation states of microglia and stroke recovery, I hope some of our study will identify new biological targets for therapeutic intervention for patients with stroke.

Hobbies & Interests
Running, basketball, badminton, movies, and stay with family.


Conelius Ngwa, Ph.D. – Postdoctoral Research Fellow

Education and Training
B.S. in Biochemistry, University of Yaoundé 1-Cameroon, 2007
M.S. in Molecular Medicine, Queen’s University Belfast-UK, 2008
Ph.D. in Biomedical Sciences, Aston University Birmingham-UK, 2014

Areas of Interests
Research Interest: Neuroinflammation in stroke and AD.
Clinical Interest: Identification of biological targets for therapeutic applications in stroke patients.

Research
My primary project focus on identifying regulatory mechanisms underlying microglia activation in stroke. I am exploring the role of microglia in ischemic stroke and cross talks of microglia, astrocytes, neurons, and other immune cells. My long term goal is to identify cellular/molecular targets of therapeutic relevance to stroke patients.

Hobbies & Interests
Playing soccer, and spending time with family and friends.


Romana Sharmeen, M.S. – Research Assistant III

Education and Training 
B.S. Child Development and Family Relations, University of Dhaka, Bangladesh (2008)
M.S. Child Development and Social Relationships, University of Dhaka (2009)
M.S.  Psychiatry, Shimane University Faculty of Medicine, Japan (2015)

Areas of Interests
Clinical Interest: Child Development and neonatal stroke
Research Interest: Sex deference in Hypoxic-Ischemic Encephalopathy

Research
My research focuses on investigating the sex differences associated with inflammatory responses in acute and chronic Hypoxic-Ischemic Encephalopathy (HIE). I am currently working on a project focusing on the manner in which activated microglia act in a sexually dimorphic manner in chronic HIE and the consequential effects on functional outcomes. We regularly use flow cytometry to determine the role of central and peripheral immune responses on neonatal stroke. Additionally, we routinely used several behavioral paradigms, including Open Field, Corner test, Hang wire test, New Object Recognition Test, and Y-Maze to test the cognitive and behavioral effects of the HIE model.

Hobbies & Interests
Traveling, listening music, playing badminton and exploring nature.