Ronald Kahn, M.D., Mary K. Iacocca Professor of Medicine at the Harvard Medical School, will present the 2016-2017 Harry E. Bovay, Jr. Annual Lecture on “Regulation of Adipose Tissue Turnover and New Mechanisms of Communication with Other Tissues.”
The lecture will be held at 11 a.m. Dec. 2, in SRB 104 (Beth Robertson Auditorium at IMM).
Kahn is the chief academic officer at Joslin Diabetes Center and a member of the National Academy of Sciences since 1999. He is recognized for his work in insulin signal transduction and mechanisms of altered signaling in diabetes. The main discoveries to come from his lab include the insulin receptor kinase, its two primary substrates, and the molecular components of the insulin signaling network. Kahn’s lab was also the first to define alterations in the signaling network in insulin resistant states, such as type 2 diabetes. More recent discoveries from his lab encompass defining alterations in the signaling network in type 2 diabetes, including the important role of insulin action in unexpected tissues such as brain, both in physiologic regulation and potentially in development of Alzheimer’s disease. His lab at Joslin also has made contributions to the understanding of obesity by showing that fat cells, called adipocytes, have different developmental origins and cellular functions that lead to risk of metabolic disease. Kahn’s work with adult humans has demonstrated that they have active brown fat that is central to redefining its role in metabolic regulation and protection from obesity.
This lecture series honors the life and work of Harry E. Bovay, Jr., 1914-2011, a distinguished visionary, entrepreneur, civic leader, and philanthropist, who made a significant contribution to the Brown Foundation of Institute of Molecular Medicine for the Prevention of Human Diseases (IMM) to help bridge the gap between the laboratory bench and the patient bedside, between identifying the molecular causes of diseases and actually preventing them.