Carl F. Ware, Ph.D.
Carl F. Ware, Ph.D.

Carl F. Ware, Ph.D., director of Infectious and Inflammatory Diseases Center at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California will present the 11th Hans J. Müller-Eberhard Memorial Lecture, “Untangling the TNF Lymphotoxin Light Cytokine Network.”

The lecture will be held at 11 a.m.-noon, Friday, April 14 in the Beth Robertson Auditorium, Fayez S. Sarofim Research Building, room 104.

Ware is a leading immunologist and internationally recognized for his scientific discovery of several members of the Tumor Necrosis Factor cytokine superfamily and their signaling circuitry. These seminal discoveries were recognized as a “Pillar of Immunology” and are being translated into novel therapeutics for autoimmune diseases and cancers.

He received his Ph.D. in molecular biology and biochemistry from the University of California, Irvine in 1979. From 1979-81, while supported by a National Research Service Postdoctoral Award from the National Institutes of Health (NIH), Ware conducted research at The University of Texas Health Science Center in San Antonio in membrane biochemistry and the complement system. In 1981, Ware joined the research groups of Jack Strominger, M.D. and Tim Springer, Ph.D. at the Dana-Farber Cancer Institute, Harvard Medical School, where he developed monoclonal antibodies to discover several membrane proteins (now known as integrins) associated with T cell function. Ware established his research laboratory in 1982, in the Biomedical Sciences Program at the University of California, Riverside, before joining the La Jolla Institute for Allergy and Immunology in 1996 as head of the Division of Molecular Immunology.

In 2010, Ware was recruited to Sanford Burnham Prebys Medical Discovery Institute as director of the Infectious and Inflammatory Diseases Center, where he continues his research in molecular immunology and virology, and translating his discoveries into new therapies for cancer, infectious and autoimmune diseases. Therapeutics based on two of Ware’s discoveries in the TNF superfamily, LTβ and LIGHT, entered clinical trials, and others are currently in development.

He is recipient of a National Merit Award from the NIH and serves on the scientific advisory boards for the Arthritis National Research Foundation and the American Asthma Foundation, past president of the International Cytokine Society, and advisor for the TNF Superfamily conferences.

This memorial lecture series honors the life and work of Hans J. Müller-Eberhard, M.D., Ph.D., 1927-1998, a distinguished molecular immunologist, first holder of the Cullen Chair in Molecular Medicine, and first director of the Institute of Molecular Medicine at The University of Texas Health Science Center at Houston.

A buffet luncheon will be provided to all attendees following the lecture. Admittance to the luncheon will require a ticket that will be handed out to those in attendance.