Education

B.Sc.
University Henri Poincare, France
M.Sc.
Molecular and Cellular Neuroscience, University Louis Pasteur
Ph.D.
Neuroscience, University Louis Pasteur
Postdoctoral Training
University of Alabama at Birmingham

Areas of Interests

Research Interests

Ophthalmology & Visual Science: visual signal processing, retinal circuitry

Neuroscience: sensory neuroscience, visual neuroscience, circadian biology

Anatomy: retinal circuitry, gap junctions, photoreceptors, confocal microscopy

Physiology: signaling pathways in the retina, light/dark adaptation, electrophysiology, biophysics, electrical coupling, computational modeling, 2-photon imaging

Synaptic plasticity: light/dark adaptive mechanisms and circadian organization of retinal function, plasticity of electrical synapses

Aging processes in the nervous system: aging-dependent decline in retinal functions
Mouse genetics: retina-specific and retinal cell-type-specific knockout mouse models

Publications

Publication Information

Bhoi, J.D., Zhang, Z., Janz, R., You, Y., Wei, H., Wu, J., and Ribelayga, C.P.: The SNARE regulator Complexin3 is a target of the cone circadian clock. J. Comp. Neurol., under revision, 2020.

Jin, N., Zhang, Z., Keung, J., Youn, S.B., Ishibashi, M., Tian, L.-M., Marshak, D.W., Solessio, E., Umino, Y., Fahrenfort, I., Kiyama, T., Mao, C.-A., You, Y., Wei, H., Wu, J., Postma, F., Paul, D.L., Massey, S.C., and Ribelayga, C.P.: Molecular and functional architecture of the mouse photoreceptor network. Sci. Adv., 6:eaba7232, 2020.

Zhang, S., Lyuboslavsky, P., Dixon, J.A., Chrenek, M.A., Sellers, J.T., Hamm, J.M., Ribelayga, C.P., Zhang, Z., Le, Y.Z., and Iuvone, P.M.: Effects of cone connexin36 disruption on light adaptation and circadian regulation of the photopic ERG. Invest. Ophthalmol. Vis. Sci., 61(6):24, 2020.

Jin, N.G., Zhang, Z., Mankiewicz, K.A., and Ribelayga, C.P.: Paired recording to study electrical coupling between photoreceptors in mouse retina. In: Mao C.-A. (ed) Retinal Development: Methods in Molecular Biology, Springer, New York (USA), invited review, 2092:221-230, 2020.

Fahrenfort, I., and Ribelayga, C.P.: Sensory processing: Visual sensitivity gets high at night. Invited comment (Dispatch). Curr. Biol. 30(1):R18-R20, 2020.

Ribelayga, C., and Mangel, S.C.: Circadian clock regulation of cone to horizontal cell synaptic transfer in the goldfish retina, PLoS One 14(8):e0218818, 2019.

Zhang, Z., Silveyra, E., Jin, N., and Ribelayga, C.P.: A congenic line of the C57Bl/6J mouse strain that is proficient in melatonin synthesis. J. Pineal Res., e12509, 2018.

Felder-Schmittbuhl, M.P., Buhr, E.D., Dkhissi-Benyahya, O., Hicks, D., Peirson, S.N., Ribelayga, C.P., Sandu, C.G., Spessert, R., and Tosini, G.: Ocular clocks: adapting mechanisms for eye function and health. Invest. Ophthalmol. Vis. Sci. 59(12):4856-4870, 2018.

Ribelayga, C.P., and O’Brien, J.: Chapter 10: Circadian and light-adaptive control of electrical synaptic plasticity in the vertebrate retina. In: Jing J (ed) Network Functions and Plasticity: Perspectives from Studying Electrical Coupling in Microcircuits, Elsevier, Cambridge (UK), invited review, pp 209-241, 2017.

Ribelayga, C.: Circadian clock photo-entrainment: the unexpected role of Opn5/neuropsin in the retina. Curr. Updates in Ophthalmol., 1:1.1, 2016.

Qiao, S.N., Zhang, Z., Ribelayga, C.P., Yang, Y.L., Zhong, Y.-M., and Zhang, D.-Q.: Multiple paradoxical cone pathways involved in photic regulation of retinal dopamine. Sci. Rep., 6:28916, 2016.

Spix, N., Liu, L.-L., Zhang, Z., Hohlbein, J., Prigge, C.L., Chintala, S., Ribelayga, C.P., and Zhang, D.-Q.: Vulnerability of dopaminergic amacrine cells to ischemia in a mouse model of oxygen-induced retinopathy. Invest. Ophthalmol. Vis. Sci., 57(7):3047-3057, 2016.

Jin, N., and Ribelayga, C.P.: Daily plasticity of electrical coupling between rod photoreceptors in the mammalian retina, J. Neurosci. 36(1):178-184, 2016.

Zhang, Z., Li, H., Liu, X., O’Brien, J., and Ribelayga, C.P.: Circadian clock control of Connexin36 phosphorylation in retinal photoreceptors of the CBA/CaJ mouse strain. Vis. Neurosci. 32:E009, 2015.

Jin, N., Chuang, A.Z., Masson, P.J., and Ribelayga, C.: Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina. J. Physiol. (London) 593(7):1597-1631, 2015.

Jin, N., Chuang, A.Z., Masson, P.J., and Ribelayga, C.: Response to letter to the Editor regarding paper by Jin et al. J. Physiol. (London) 593(13):2977-2978, 2015.

Mao, C.-A., Li, H., Zhang, Z., Kiyama, T., Panda, S., Hattar, S., Ribelayga, C., Mills, S.L., and Wang, S.W.: Tbr2 is essential for the formation and maintenance of Opn4/melanopsin-expressing intrinsically photosensitive retinal ganglion cells. J. Neurosci. 34(39):13083-13095, 2014.

Li, H., Zhang, Z., Blackburn, M.R., Wang, S.W., Ribelayga, C., and O’Brien, J.: Adenosine and dopamine receptors co-regulate photoreceptor coupling via gap junction phosphorylation in mouse retina. J. Neurosci. 33(7):3135-3150, 2013.

Liu, X., Zhang, Z., and Ribelayga, C.: Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina. PLoS One 7(11):e50602, 2012.

Choi, H.-J., Ribelayga, C., and Mangel, S.C.: Cut-loading: a useful tool for examining the extent of gap junctional tracer coupling between retinal neurons. J. Vis. Exp. 59:e3180, 2012.

Ribelayga, C., and Mangel, S.C.: Identification of a circadian clock-controlled pathway in the mammalian retina. PLoS One 5(6):e11020, 2010.

Ribelayga, C.: Vertebrate vision: TRP channels in the spotlight. Curr. Biol. 20(6):R278-R280, 2010.

Mangel, S.C., and Ribelayga, C.: Comparative eye: The circadian clock in the retina regulates rod and cone pathways. In: Dartt DA, Besharse JC, Dana R (eds) Encyclopedia of the Eye, Elsevier, Oxford (UK), Vol. 1, pp 283-289, 2010.

Ribelayga, C., Cao, Y., and Mangel, S.C.: The circadian clock in the retina regulates rod-cone coupling. Neuron 59(5):790-801, 2008 (Featured Article of the week; highlighted in Faculty of 1000 Biology).

Ribelayga, C., and Mangel, S.C.: Gap junctional coupling between fish rod horizontal cells: Modulation by light and dopamine but not the retinal circadian clock. Vis. Neurosci. 24(3):333-344, 2007.

Simonneaux, V., Garidou, M.L., Ribelayga, C., and Pevet, P.: Mechanisms underlying seasonal regulation of melatonin synthesis in rodents. In: Pandi-Perumal SR, Cardinali DP (eds) Melatonin. Biological Basis of its Function in Health and Disease, Landes Bioscience, Georgetown (TX, USA), pp 1-11, 2005.

Pitrosky, B., Ribelayga, C., Simonneaux, V., Pévet, P., and Vivien-Roels, B.: Environmental control and adrenergic regulation of pineal activity in the diurnal tropical rodent, Arvicantis ansorgei. J. Pineal Res. 38(3):189-197, 2005.

Ribelayga, C., and Mangel, S.C.: A circadian clock and light/dark adaptation differentially regulate adenosine in the mammalian retina. J. Neurosci. 25(1):215-222, 2005.

Ribelayga, C., Wang, Y., and Mangel, S.C.: A circadian clock in the fish retina regulates dopamine release via activation of melatonin receptors. J. Physiol. (London) 554(Pt 2):467-482, 2004.

Ribelayga, C., and Mangel, S.C.: Absence of circadian clock regulation of horizontal cell gap junctional coupling reveals two dopamine systems in the goldfish retina. J. Comp. Neurol. 467(2):243-253, 2003.

Simonneaux, V., and Ribelayga, C.: Generation of the melatonin endocrine message in mammals: A review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol. Rev. 55(2):325-395, 2003.

Simonneaux, V., Ribelayga, C., and Revel, F.: Hydroxyindole-O-methyltransferase, a season-coding enzyme for melatonin synthesis in the pineal gland of rodents. Biol. Rhythm Res. 33(4):401-416, 2002.

Garidou, M.L., Ribelayga, C., Pévet, P., and Simonneaux, V.: Syrian hamster and rat display developmental differences in the regulation of pineal arylalkylamines N-acetyltransferase. J. Neuroendocrinol. 14(11):861-868, 2002.

Simonneaux, V., and Ribelayga, C.: Neuropeptide Y, an important modulator of the noradrenergic input of the mammalian pineal gland. In: Haldar C, Singaravel M, Maitra SK (eds) Treatise on Pineal Gland and Melatonin. Science Publishers, Inc., Enfield (NH, USA), Plymouth (UK), pp 371-393, 2002.

Ribelayga, C., Wang, Y., and Mangel, S.C.: Dopamine mediates circadian clock regulation of rod and cone input to fish horizontal cells. J. Physiol. (London) 544(Pt 3):801-816, 2002.

Zhang, D.Q., Ribelayga, C., Mangel, S.C., and McMahon, D.G.: Suppression by zinc of AMPA receptor-mediated synaptic transmission in the retina. J. Neurophysiol. 88(3):1245-1251, 2002.

Simonneaux, V., and Ribelayga, C.: Neuropeptide Y, an important modulator of the noradrenergic input of the mammalian pineal gland. In: Haldar C, Singaravel M, Maitra SK (eds) Treatise on Pineal Gland and Melatonin. Science Publishers, Inc., Enfield (NH, USA), Plymouth (UK), pp 371-393, 2002.

Ribelayga, C., Pévet, P., and Simonneaux, V.: HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the siberian hamster. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278(5):R1339-R1345, 2000.

Ribelayga, C., Garidou, M.L., Malan, A., Gauer, F., Calgari, C., Pévet, P., and Simonneaux, V.: Photoperiodic control of the rat pineal arylalkylamine-N-acetyltransferase and hydroxyindole-O-methyltransferase gene expression and its consequence on melatonin synthesis. J. Biol. Rhythms 14(2):105-115, 1999.

Ribelayga, C., Gauer, F., Calgari, C., Pévet, P., and Simonneaux, V.: Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase (HIOMT) messenger ribonucleic acid expression: an analysis of its complex relationship with HIOMT activity. Endocrinology 140(3):1375-1384, 1999.

Ribelayga, C., Gauer, F., Pévet, P., and Simonneaux, V.: Ontogenesis of hydroxyindole-O-methyltransferase gene expression and activity in the rat pineal gland. Brain Res. Dev. Brain Res. 110(2):235-239, 1998.

Ribelayga, C., Pévet, P., and Simonneaux, V.: Possible involvement of neuropeptide Y in the seasonal control of hydroxyindole-O-methyltransferase in the pineal gland of the European hamster (Cricetus cricetus). Brain Res. 801(1-2):137-142, 1998.

Ribelayga, C., Pévet, P., and Simonneaux, V.: Adrenergic and peptidergic regulations of hydroxyindole-O-methyltransferase activity in rat pineal gland. Brain Res. 777(1-2):247-250, 1997.

Simonneaux, V., Ribelayga, C., Miguez, J.M., and Pévet, P.: Physiological role of neuropeptides in the mammalian pineal gland. In: Tang PL, Pang SF, Reiter RJ (eds) Melatonin: A Universal Photoperiodic Signal with Diverse Actions. Frontiers for Hormone Research, vol. 21. Karger, Basel (CH), pp 24-29, 1997.

Simonneaux, V., Ribelayga, C., and Miguez, J.M.: Peptidergic modulation of rat pineal synthetic and secretory activities: example of VIP and NPY. In: Webb SM, Puig-Domingo M, Møller M, Pévet P (eds) Pineal Update 1997: From Molecular Biology to Clinical Medicine. P.J.D. Publications Ltd, Westbury, New-York (NY, USA), pp 149-159, 1997.