Education

B.Sc.
University Henri Poincare, France
M.Sc.
Molecular and Cellular Neuroscience, University Louis Pasteur
Ph.D.
Neuroscience, University Louis Pasteur
Postdoctoral Training
University of Alabama at Birmingham

Research Information

Ophthalmology & Visual Science: basic visual processing, retinal circuitry
Neuroscience: sensory neuroscience, visual neuroscience, circadian biology
Anatomy: retinal circuitry, gap junctions, photoreceptors
Physiology: signaling pathways in the retina, adaptation, electrophysiology, biophysics, electrical coupling, computational modeling
Synaptic plasticity: light/dark adaptive mechanisms and circadian organization of retinal function, plasticity of electrical synapses
Aging processes in the nervous system: aging-dependent decline in retinal function
Mouse genetics: cell-type-specific circadian-clock-deficient mouse models

Publications

Publication Information

  • Ribelayga, C.P., and O’Brien, J.: Circadian and light-adaptive control of electrical synaptic plasticity in the vertebrate retina. In: Jing J. (ed) Network Functions and Plasticity: Perspectives from Studying Electrical Coupling in Microcircuits, Elsevier, Cambridge (UK), invited review, under review, 2016.
  • Jin, N., and Ribelayga, C.P.: Daily plasticity of electrical coupling between rod photoreceptors in the mammalian retina, J. Neurosci. 36(1):178-184, 2016.
  • Zhang, Z., Li, H., Liu, X., O’Brien, J., and Ribelayga, C.P.: Circadian clock control of Connexin36 phosphorylation in retinal photoreceptors of the CBA/CaJ mouse strain. Vis. Neurosci. 32:E009, 2015.
  • Jin, N., Chuang, A.Z., Masson, P.J., and Ribelayga, C.: Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina. J. Physiol. (London) 593(7):1597-1631, 2015.
  • Jin, N., Chuang, A.Z., Masson, P.J., and Ribelayga, C.: Response to letter to the Editor regarding paper by Jin et al. J. Physiol. (London) 593(13):2977-2978, 2015.
  • Mao, C.-A., Li, H., Zhang, Z., Kiyama, T., Panda, S., Hattar, S., Ribelayga, C., Mills, S.L., and Wang, S.W.: Tbr2 is essential for the formation and maintenance of Opn4/melanopsin-expressing intrinsically photosensitive retinal ganglion cells. J. Neurosci. 34(39):13083-13095, 2014.
  • Li, H., Zhang, Z., Blackburn, M.R., Wang, S.W., Ribelayga, C., and O’Brien, J.: Adenosine and dopamine receptors co-regulate photoreceptor coupling via gap junction phosphorylation in mouse retina. J. Neurosci. 33(7):3135-3150, 2013.
  • Liu, X., Zhang, Z., and Ribelayga, C.: Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina. PLoS One 7(11):e50602, 2012.
  • Choi, H.-J., Ribelayga, C., and Mangel, S.C.: Cut-loading: a useful tool for examining the extent of gap junctional tracer coupling between retinal neurons. J. Vis. Exp. 59:e3180, 2012.
  • Ribelayga, C., and Mangel, S.C.: Identification of a circadian clock-controlled pathway in the mammalian retina. PLoS One 5(6):e11020, 2010.
  • Ribelayga, C.: Vertebrate vision: TRP channels in the spotlight. Curr. Biol. 20(6):R278-R280, 2010.
  • Mangel, S.C., and Ribelayga, C.: Comparative eye: The circadian clock in the retina regulates rod and cone pathways. In: Dartt DA, Besharse JC, Dana R (eds) Encyclopedia of the Eye, Elsevier, Oxford (UK), Vol. 1, pp 283-289, 2010.
  • Ribelayga, C., Cao, Y., and Mangel, S.C.: The circadian clock in the retina regulates rod-cone coupling. Neuron 59(5):790-801, 2008 (Featured Article of the week; highlighted in Faculty of 1000 Biology).
  • Ribelayga, C., and Mangel, S.C.: Gap junctional coupling between fish rod horizontal cells: Modulation by light and dopamine but not the retinal circadian clock. Vis. Neurosci. 24(3):333-344, 2007.
  • Garidou-Boof, M.L., Sicard, B., Bothorel, B., Simonneaux, V., Garidou, M.L., Ribelayga, C., and Pevet, P.: Mechanisms underlying seasonal regulation of melatonin synthesis in rodents. In: Pandi-Perumal SR, Cardinali DP (eds) Melatonin. Biological Basis of its Function in Health and Disease, Landes Bioscience, Georgetown (TX, USA), pp 1-11, 2005.
  • Pitrosky, B., Ribelayga, C., Simonneaux, V., Pévet, P., and Vivien-Roels, B.: Environmental control and adrenergic regulation of pineal activity in the diurnal tropical rodent, Arvicantis ansorgei. J. Pineal Res. 38(3):189-197, 2005.
  • Ribelayga, C., and Mangel, S.C.: A circadian clock and light/dark adaptation differentially regulate adenosine in the mammalian retina. J. Neurosci. 25(1):215-222, 2005.
  • Ribelayga, C., Wang, Y., and Mangel, S.C.: A circadian clock in the fish retina regulates dopamine release via activation of melatonin receptors. J. Physiol. (London) 554(Pt 2):467-482, 2004.
  • Ribelayga, C., and Mangel, S.C.: Absence of circadian clock regulation of horizontal cell gap junctional coupling reveals two dopamine systems in the goldfish retina. J. Comp. Neurol. 467(2):243-253, 2003.
  • Simonneaux, V., and Ribelayga, C.: Generation of the melatonin endocrine message in mammals: A review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol. Rev. 55(2):325-395, 2003.
  • Simonneaux, V., Ribelayga, C., and Revel, F.: Hydroxyindole-O-methyltransferase, a season-coding enzyme for melatonin synthesis in the pineal gland of rodents. Biol. Rhythm Res. 33(4):401-416, 2002.
  • Garidou, M.L., Ribelayga, C., Pévet, P., and Simonneaux, V.: Syrian hamster and rat display developmental differences in the regulation of pineal arylalkylamines N-acetyltransferase. J. Neuroendocrinol. 14(11):861-868, 2002.
  • Ribelayga, C., Wang, Y., and Mangel, S.C.: Dopamine mediates circadian clock regulation of rod and cone input to fish horizontal cells. J. Physiol. (London) 544(Pt 3):801-816, 2002.
  • Zhang, D.Q., Ribelayga, C., Mangel, S.C., and McMahon, D.G.: Suppression by zinc of AMPA receptor-mediated synaptic transmission in the retina. J. Neurophysiol. 88(3):1245-1251, 2002.
  • Simonneaux, V., and Ribelayga, C.: Neuropeptide Y, an important modulator of the noradrenergic input of the mammalian pineal gland. In: Haldar C, Singaravel M, Maitra SK (eds) Treatise on Pineal Gland and Melatonin. Science Publishers, Inc., Enfield (NH, USA), Plymouth (UK), pp 371-393, 2002.
  • Ribelayga, C., Pévet, P., and Simonneaux, V.: HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the siberian hamster. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278(5):R1339-R1345, 2000.
  • Ribelayga, C., Garidou, M.L., Malan, A., Gauer, F., Calgari, C., Pévet, P., and Simonneaux, V.: Photoperiodic control of the rat pineal arylalkylamine-N-acetyltransferase and hydroxyindole-O-methyltransferase gene expression and its consequence on melatonin synthesis. J. Biol. Rhythms 14(2):105-115, 1999.
  • Ribelayga, C., Gauer, F., Calgari, C., Pévet, P., and Simonneaux, V.: Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase (HIOMT) messenger ribonucleic acid expression: an analysis of its complex relationship with HIOMT activity. Endocrinology 140(3):1375-1384, 1999.
  • Ribelayga, C., Gauer, F., Pévet, P., and Simonneaux, V.: Ontogenesis of hydroxyindole-O-methyltransferase gene expression and activity in the rat pineal gland. Brain Res. Dev. Brain Res. 110(2):235-239, 1998.
  • Ribelayga, C., Pévet, P., and Simonneaux, V.: Possible involvement of neuropeptide Y in the seasonal control of hydroxyindole-O-methyltransferase in the pineal gland of the European hamster (Cricetus cricetus). Brain Res. 801(1-2):137-142, 1998.
  • Ribelayga, C., Pévet, P., and Simonneaux, V.: Adrenergic and peptidergic regulations of hydroxyindole-O-methyltransferase activity in rat pineal gland. Brain Res. 777(1-2):247-250, 1997.
  • Simonneaux, V., Ribelayga, C., Miguez, J.M., and Pévet, P.: Physiological role of neuropeptides in the mammalian pineal gland. In: Tang PL, Pang SF, Reiter RJ (eds) Melatonin: A Universal Photoperiodic Signal with Diverse Actions. Frontiers for Hormone Research, vol. 21. Karger, Basel (CH), pp 24-29, 1997.
  • Simonneaux, V., Ribelayga, C., and Miguez, J.M.: Peptidergic modulation of rat pineal synthetic and secretory activities: example of VIP and NPY. In: Webb SM, Puig-Domingo M, Møller M, Pévet P (eds) Pineal Update 1997: From Molecular Biology to Clinical Medicine. P.J.D. Publications Ltd, Westbury, New-York (NY, USA), pp 149-159, 1997.