
John O'Brien, PhD
- Professor, Ruiz Department of Ophthalmology & Visual Science
- Frederic B. Asche Chair, Department of Ophthalmology & Visual Science
Education
- B.A.
- Biology, Bowdoin College
- Ph.D
- University of California, San Diego (Lab of George Somero, Ph.D., Scripps Institution of Oceanography)
- Postdoctoral Training
- Lab of Barbara Block, PhD, University of Chicago
- Postdoctoral Training
- Lab of Harris Ripps, D.Sc., University of Illinois, Chicago
Areas of Interest
Research Interests
Visual adaptation, electrical synapses, synaptic plasticity, vision, zebrafish genetics, signal transduction
Publications
Publication Information
- O’Brien, J. The ever-changing electrical synapse. Current Opinion in Neurobiology 29:64-72, 2014.
- Li, H., Chuang, A.Z., and O’Brien, J. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis. Neurosci. 31(3): 237-243, 2014. doi:10.1017/S095252381300062X Full Text
- Rash, J.E., Curti, S., Davidson, K.G.V., Kamasawa, N., Nannapaneni, S., Flores, C.E., Yasumura, T., O’Brien, J., Lynn, B.D., Nagy, J.I., and Pereda, A.E. Molecular and functional asymmetry at a vertebrate electrical synapse. Neuron 79(5): 957-969, 2013. PMCID: PMC4020187. Full Text
- Palacios-Prado, N., Hoge, G, Marandykina, A., Rimkute, L., Chapuis, S., Paulauskas, N., Skeberdis, V.A., O’Brien, J., Pereda, A.E., Bennett, M.V.L., and Bukauskas, F.F. Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36. J. Neurosci. 33(11): 4741-4753, 2013. PMCID: PMC3635812. Full Text
- 5. Li, H., Zhang, Z., Blackburn, M.R., Wang, S.W., Ribelayga, C.P. and O’Brien, J. Adenosine and dopamine receptors co-regulate photoreceptor coupling via gap junction phosphorylation in mouse retina. J. Neurosci. 33(7): 3135-3150, 2013. PMCID: PMC3711184. Full Text
- Kothmann, W.W., Trexler, E.B., Whitaker, C.M., Li, W., Massey, S.C., and O’Brien, J. Nonsynaptic NMDA receptors mediate activity-dependent plasticity of gap junctional coupling in the AII amacrine cell network. J. Neurosci. 32(20): 6747-6759, 2012. PMCID: PMC3367513. Full Text
- Li, H., and O’Brien, J.: Regulation of gap junctional coupling in photoreceptors. In Photoreceptors: Physiology, Types and Abnormalities. Eds. E. Akutagawa and K. Ozaki. Nova Science (Hauppauge, NY). pp 97-112, 2012. Full Text
- O’Brien J.J., Chen, X., MacLeish, P.R., O’Brien J., and Massey S.C. Photoreceptor Coupling mediated by Connexin 36 in the Primate Retina. J. Neurosci. 32(13): 4675-4687, 2012. PMCID: PMC3335500 Full Text
- Pan, F., Keung, J., Kim, I.-B., Snuggs, M.B., Mills, S.L., O’Brien, J., and Massey, S.C. Connexin 57 is expressed by the axon terminal network of B-type horizontal cells in the rabbit retina. J. Comp. Neurol. 520(10): 2256-2274, 2012. Full Text
- Vila, A., Satoh, H., Rangel, C., Mills, S.L., Hoshi, H., O’Brien, J., Marshak, D.R., MacLeish, P.R., and Marshak, D.W. Histamine receptors of cones and horizontal cells in old world monkey retinas. J. Comp. Neurol. 520(3): 528-543, 2012. PMCID: PMC3272842 Full Text
- Li, H., Chuang, A.Z., and O’Brien, J. Photoreceptor coupling is controlled by connexin 35 phosphorylation in zebrafish retina. J. Neurosci. 29(48): 15178-15186, 2009. PMCID: PMC2909833 Full Text
- Kothmann, W.W., Massey, S.C., and O’Brien, J. Dopamine-stimulated dephosphorylation of connexin 36 mediates AII amacrine cell uncoupling. J. Neurosci. 29(47): 14903-14911, 2009. PMCID: PMC2839935 Full Text