Education

B.A.
Biology, Bowdoin College
Ph.D
University of California, San Diego (Lab of George Somero, Ph.D., Scripps Institution of Oceanography)
Postdoctoral Training
Lab of Barbara Block, PhD, University of Chicago
Postdoctoral Training
Lab of Harris Ripps, D.Sc., University of Illinois, Chicago

Areas of Interest

Research Interests

Visual adaptation, electrical synapses, synaptic plasticity, vision, zebrafish genetics, signal transduction

Publications

Publication Information

  1. O’Brien, J.  The ever-changing electrical synapse.  Current Opinion in Neurobiology 29:64-72, 2014.
  2. Li, H., Chuang, A.Z., and O’Brien, J.  Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.  Vis. Neurosci. 31(3): 237-243, 2014.  doi:10.1017/S095252381300062X   Full Text
  3. Rash, J.E., Curti, S., Davidson, K.G.V., Kamasawa, N., Nannapaneni, S., Flores, C.E., Yasumura, T., O’Brien, J., Lynn, B.D., Nagy, J.I., and Pereda, A.E.  Molecular and functional asymmetry at a vertebrate electrical synapse. Neuron 79(5): 957-969, 2013.  PMCID: PMC4020187.   Full Text
  4. Palacios-Prado, N., Hoge, G, Marandykina, A., Rimkute, L., Chapuis, S., Paulauskas, N., Skeberdis, V.A., O’Brien, J., Pereda, A.E., Bennett, M.V.L., and Bukauskas, F.F.  Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36.  J. Neurosci. 33(11): 4741-4753, 2013.  PMCID: PMC3635812.   Full Text
  5. 5.     Li, H., Zhang, Z., Blackburn, M.R., Wang, S.W., Ribelayga, C.P. and O’Brien, J.  Adenosine and dopamine receptors co-regulate photoreceptor coupling via gap junction phosphorylation in mouse retina. J. Neurosci. 33(7): 3135-3150, 2013.  PMCID: PMC3711184.   Full Text
  6. Kothmann, W.W., Trexler, E.B., Whitaker, C.M., Li, W., Massey, S.C., and O’Brien, J.  Nonsynaptic NMDA receptors mediate activity-dependent plasticity of gap junctional coupling in the AII amacrine cell network.  J. Neurosci. 32(20): 6747-6759, 2012.  PMCID: PMC3367513.  Full Text
  7. Li, H., and O’Brien, J.:  Regulation of gap junctional coupling in photoreceptors.  In Photoreceptors: Physiology, Types and Abnormalities.  Eds. E. Akutagawa and K. Ozaki.  Nova Science (Hauppauge, NY). pp 97-112, 2012.  Full Text
  8. O’Brien J.J., Chen, X., MacLeish, P.R., O’Brien J., and Massey S.C.  Photoreceptor Coupling mediated by Connexin 36 in the Primate Retina. J. Neurosci. 32(13): 4675-4687, 2012.  PMCID: PMC3335500   Full Text
  9. Pan, F., Keung, J., Kim, I.-B., Snuggs, M.B., Mills, S.L., O’Brien, J., and Massey, S.C. Connexin 57 is expressed by the axon terminal network of B-type horizontal cells in the rabbit retina.  J. Comp. Neurol. 520(10): 2256-2274, 2012.  Full Text
  10. Vila, A., Satoh, H., Rangel, C., Mills, S.L., Hoshi, H., O’Brien, J., Marshak, D.R., MacLeish, P.R., and Marshak, D.W.  Histamine receptors of cones and horizontal cells in old world monkey retinas.  J. Comp. Neurol. 520(3): 528-543, 2012.  PMCID: PMC3272842  Full Text
  11. Li, H., Chuang, A.Z., and O’Brien, J.  Photoreceptor coupling is controlled by connexin 35 phosphorylation in zebrafish retina. J. Neurosci. 29(48): 15178-15186, 2009. PMCID: PMC2909833  Full Text
  12. Kothmann, W.W., Massey, S.C., and O’Brien, J.  Dopamine-stimulated dephosphorylation of connexin 36 mediates AII amacrine cell uncoupling. J. Neurosci. 29(47): 14903-14911, 2009. PMCID: PMC2839935   Full Text