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Catherine Ambrose, Ph.D.

Catherine G. Ambrose, Ph.D.

Office telephone: 713-500-7007

Languages: english

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Catherine G. Ambrose, Ph.D.

Associate Professor

Specialties: Research
 

Education & Training

Undergraduate School

Washington University in St. Louis, St. Louis, Missouri
B.S. Mechanical Engineering

Graduate School

University of Texas at Austin, Austin, Texas
M.S. Biomedical Engineering
University of Texas at Austin, Austin, Texas
Ph.D. Mechanical Engineering

Interests, Publications, & Achievements

Areas of Research Interest

CURRENT GRANT SUPPORT:
Title: “The Role of Biofilm on Margin Stability and the Development of Secondary Caries”
Source: The National Institute of Dental and Craniofacial Research
PI: S. Ray Taylor, PhD
Co-I:Catherine Ambrose, PhD and Heidi Kaplan, PhD
9/1/2010-8/31/2014 $1,519,214

Title: “Resident and Fellow Research and Education"
Source: Zimmer, Inc
PI: Catherine Ambrose, Ph.D.
Co-PI: Dhiren Sheth, MD.
8/05/05-12/31/20 $50,000

PAST GRANT SUPPORT: Title: “Testing for Contrasting Infection Rates and Biofilm Formation Among Biomaterials in an in vitro Biofilm Infection Model”
Source: Stryker, Inc
PI: Catherine Ambrose, PhD
Co-I:Milan Sen, MD and Heidi Kaplan
1/1/2010-6/30/11 $32,486

Title: “PC-NSAIDs: Gastrointestinal-safe and potent anti-inflammatory drugs”
Source: US Army SBIR Phase II
PI: PLX-Pharma
Subcontract: Catherine Ambrose, PhD ($34,905 per year)
11/25/08-12/24/10 $729,991.79

Title: “Bioengineering Masters Degree Program”
Source: Encore Medical
PI: Alex Rosenstein, MD
Co-PI: Catherine Ambrose, PhD
7/1/2008-6/30/2010 $153,166

Title: “Identification of Causative Bacteria in Osteomyelitis Using Rapid and Sensitive 16SrRNA Detection”
Source: Orthopaedic Research & Education Foundation
PI: Catherine Ambrose, PhD
Co-I: Terry Clyburn, MD, Heidi Kaplan, PhD
7/01/07-6/30/10 $150,000

Title: “PC-NSAIDs: Gastrointestinal-safe and potent anti-inflammatory drugs”
Source: US Army SBIR Phase I
PI: PLX-Pharma
Subcontract: Catherine Ambrose, PhD ($7700)
11/11/07-6/10/08 $69,997.08

Title: “Biomechanical Evaluation of Anatomic Contoured Locking Plates for Periarticular Fractures”
Source: Zimmer, Inc
PI: Catherine Ambrose, PhD
Co-I: Dhiren Sheth, MD
8/15/05-8/15/07 $80,947

Title: “Evaluation of Trabecular Metal Implants and Biodegradable Microspheres Impregnated with BMP2”
Source: Zimmer, Inc
PI: Catherine Ambrose, PhD
Co-I: Dhiren Sheth, MD
4/16/06-12/19/07 $214,633

Title: "Evaluation of Trabecular Metal Implants and Antibiotic Impregnated Microspheres in Osteomyelitis "
Source: Zimmer, Inc
PI: Catherine Ambrose, Ph.D.
Co-PI: Terry Clyburn, M.D.
7/01/05-7/27/07 $119,770

Title: "Effects of NSAIDs on Osteointegration – Continuing Studies"
Source: Zimmer, Inc
PI: Catherine Ambrose, Ph.D.
Co-PI: Dhiren Sheth, MD.
7/01/05-7/27/07 $88,615

Title: “Effects of NSAIDs on Osteointegration”
Source: Zimmer, Inc
PI: Catherine Ambrose, PhD

Selected Publications

Abstracts
1. Ambrose, C.G.: Graphical Simulation Environment for Locomotion Analysis, 12th Annual Houston Conference on Biomedical Engineering Research, Houston, February 1994.
2. Ambrose, C.G., Daum, W.J., and Solvelius, P.E.: A Comparison of Contouring Techniques for Locating Bony Landmarks Using MR and CT Imaging, 13th Annual Houston Conference on Biomedical Engineering Research, Houston, February, 1995.
3. Ambrose, C.G., Daum, W.J., Solvelius, P.E., Kulkarni, M., and Kaufman, B.: Validation of Bony Landmarks Derived From 3-D reconstructions of MR and CT Images, Transactions of the 41st Annual Meeting of the Orthopaedic Research Society, Volume 2:800, Atlanta, 1995.
4. Ambrose, R.O., and Ambrose, C.G.: Robot Models for Space Environments. Proceedings of the 1995 IEEE International Conference on Robotics and Automation, May 1995.
5. Ambrose, C.G., Reuben, J.D., and Andreo, M.A.: Automatic Measurement System for Orthopaedic Applications – Total Hip Arthroplasty and Patello-Femoral Kinematics, Annual Fall Meeting of the Biomedical Engineering Society, Boston, 1995.
6. Kramer, R.C., Masson, M.V., and Ambrose, C.G.: The Effect of Wrist, MP and IP Joint Position on Extensor Tendon Tension, Annual Meeting of the American Association of Orthopaedic Surgeons, Atlanta, Georgia, 1996.
7. Ambrose, C.G. and Ambrose, R.O.: Non-Invasive Motion Measurement for Orthopaedic Kinematic Measurements, 14th Annual Houston Conference on Biomedical Engineering Research, Houston, February 1996
8. Ambrose, R.O., and Ambrose, C.G.: Kinetics of Two-Handed Climbing Gaits in Zero Gravity, 14th Annual Houston Conference on Biomedical Engineering Research, Houston, February 1996.
9. Ambrose, C.G., Ward, L., Masson, M., and Lavarro, F.: Viscoelastic Models of the Distal Radio-Ulnar Joint, 15th Annual Houston Conference on Biomedical Engineering Research, Houston, February, 1997.
10. Hogan, H., Lin, C., Ambrose, C.G., Evans, H., Harrigan, T., Shackelford, L., and LeBlanc, A.: Relations Between Trabecular Bone Properties and MRI Relaxation Times, ASME IMECE97 Bioengineering Division Meeting, Dallas, Texas, November 16-21, BED Vol 36:325-326, 1997.
11. Ambrose, C.G., Brennan, M., and Gogola, G.R.: Correlation of Mechanical Strength with Bone Loss in Ovariectomized Rat Model, Transactions of the Forty-Fourth Annual Meeting of the Orthopaedic Research Society, New Orleans, 1998.
12. Ambrose, C.G., Gogola, G.R., Brennan, M.S.: The Effect of NSAIDs and Correlation of Mechanical Strength in Hormone-Deficient Osteoporosis, 16th Annual Houston Conference on Biomedical Engineering Research, Houston, April 1998.
13. Ambrose, C.G., Gogola, G.R., Stancel, G.: Musculoskeletal Effects of Neonatal Exposure to Natural and Synthetic Estrogens, 17th Annual Houston Conference on Biomedical Engineering Research, Houston, 1999.
14. Gogola, G.R., Ambrose, C.G., Mikos, A., Peng, A.: PLGA/PEG Microspheres as an Antibiotic Delivery System for Osteomyelitis, 17th Annual Houston Conference on Biomedical Engineering Research, Houston, 1999.
15. Timmer, M.D., He, S., Mikos, A.G., Ambrose, C.G.: Investigation of a Poly(Propylene Fumerate)-Based Polymer for Bioresorbable Interbody Fusion Cage, 18th Annual Houston Conference on Biomedical Engineering Research, Houston, 2000.
16. Gogola, G., Ambrose, C.G., Peng, A., Mikos, A.: PLGA/PEG Microspheres as an Antibiotic Delivery System, 46th Annual Meeting of the Orthopaedic Research Society, Orlando, FL, March 11-14, 2000.
17. Ambrose, C.G, Meyers, N., Beaver, R., Clyburn, T.A.: Evaluation of Resorbable Ceramic Bone Void Fillers Using a Critical-Size Defect in a Sheep Model, 18th Annual Houston Conference on Biomedical Engineering Research, Houston, 2000.
18. Ambrose, C.G., Gogola, G., and Brennan, M.: The Effects of Indomethacin and Ibuprofen on Hormone-Deficient Bone Density Loss in an Ovariectomized Mature Rat Model, the World Congress on Osteoporosis 2000, Chicago, Osteoporosis International 11(Suppl 2):S170-S171, June 2000.
19. Sabonghy, P., Ambrose, C.A., Wood, R.M., Clanton, T.O.: Tendon Transfer Fixation in the Foot and Ankle: Biomechanical Comparison of a Traditional Fixation Technique Verses Bioabsorbable Interference-Fit Screw Fixation, American Academy of Orthopaedic Surgeons Annual Meeting, San Francisco, 2001.
20. Louden, K.W., Beaty, S.G., Clanton, T.O., Ambrose, C.G.: Tendon Transfer Fixation in the Foot and Ankle: A Biomechanical Study Evaluating Two Sizes of Bioabsorbable Screws, 19th Annual Houston Conference on Biomedical Engineering Research, Houston, 2001.
21. Clubb F, Peterson M, Coscio M, Ambrose C, Wolff R, Rossi A, Sedlik S, Rose B, Urban J, Buja M, McClay C. The Use of Integrated microscopic Techniques for Analyzing Implanted Vascular Stents. 21st Annual S&T Conference, 2001.
22. Timmer, M.D., Ambrose, C.G., Mikos, A.G.: Quantification of the Crosslinking Density of Poly(Propylene Fumerate)-Based Biodegradable Networks, American Institute of Chemical Engineers Fall Meeting, 2001.
23. Timmer, M.D., He, S., Ambrose, C.G., Mikos, A.G.: Mechanical Properties of Photo-Initiated Biodegradable Polymer Networks for Prefabricated Orthopaedic Scaffolds, Society for Biomaterials Annual Meeting, 2001.
24. Guzel VB, Kent M, Ambrose C, Koeck W, Schults J, Coupe KJ: Biomechanical Evaluation of Internal Fixation Techniques in Unstable Intertrochanteric Femur Fractures. The 8th Meeting of the International Society for Fracture Repair, Toronto, Ontario, Canada; 2002.
25. Kiebzak GM, Beinart GA, Perser K, Ambrose C, Siff SJ, Heggeness MH: Undertreatment of osteoporosis in men with hip fracture. Poster presentation at the Annual Meeting of the International Society for Clinical Densitometry, Atlanta, GA, 2002. Journal of Clinical Densitometry 5 (Supplement): S47. This presentation won the "Outstanding Clinical Abstract" award.
26. Ambrose CG, Kiebzak GM, Tabor OB, Peindl RD, Anderson RB, Davis WH, Clanton TO: Biomechanical testing of cadaveric specimens: importance of bone mineral density assessment. Poster presentation at the Annual Meeting of the International Society for Clinical Densitometry, Atlanta, GA, 2002. Journal of Clinical Densitometry 5 (Supplement): S47.
27. Guzel, V., Kent, M., Ambrose, C, Meyers, N. and Coupe, K: Biomechanical Evaluation of Internal Fixation Techniques in Unstable Intertrochanteric Femur Fractures. 20th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, April 4, 2003.
28. Lemmon, H, Johnson, E, Cody, DD, Ambrose, CG, and Hogan, HA: Regional Variations in Cancellous BMD Within the Distal Metaphysis of the Rat Femur. American Society for Bone and Mineral Research, 2003 Annual Meeting, Minneapolis, Minnesota, Journal of Bone and Mineral Research 18(supplement2):S206-S207, 2003.
29. Clyburn, TA, Ambrose, CG, and Weitz-Marshall: Constrained Acetabulum – A Biomechanical, Cadaver-Model Study. 67th Annual Western Orthopaedic Association Annual Meeting, San Antonio, October 2003. 30. Clyburn, TA and Ambrose , CG: Antibiotic Microspheres for the Treatment and Prevention of Orthopaedic Infections. 67th Annual Western Orthopaedic Association Annual Meeting, San Antonio, October 2003.
31. Clyburn, TA and Ambrose, CG: Cement Injection into the Femur – An Improved Technique. 67th Annual Western Orthopaedic Association Annual Meeting, San Antonio, October 2003.
32. Martin, S, Kiebzak, GM, Ambrose, CG: Fracture Risk Assessment Discrepancy Among Three Quantitative Ultrasound Systems. International Society for Clinical Densitometry, 2004 Annual Meeting, Miami Florida, Journal of Clinical Densitometry 7(2):248, 2004.
33. Kiebzak, GM, Martin, S., and Ambrose, CG: Comparing Precision Values: Impact of Study Design and Statistical Techniques. International Society for Clinical Densitometry, 2004 Annual Meeting, Miami Florida, Journal of Clinical Densitometry 7(2):248, 2004
34. Kiebzak, GM, Ambrose, CG, Schmeer, P: Insoluble Intestinal Calcium Complexes May Affect Monitoring but Not Diagnosis. International Society for Clinical Densitometry, 2004 Annual Meeting, Miami Florida, Journal of Clinical Densitometry 7(2):239, 2004
35. Huang, RP, Ambrose, CG, Sullivan, E., Haynes, R.J.: Functional Significance of DEXA Measurements in Patients with Osteogenesis Imperfecta. Poster presentation at the Pediatric Orthopaedic Society of North America (POSNA) Annual Meeting, St. Louis, MO, April 29, 2004.
36. Temenoff JS, Park H, Jabbari E, Sheffiels TL, Lebaron RG, Ambrose CG, Mikos AG. Swelling of fumarate-based hydrogels affects osteogenic differentiation of embedded marrow stromal cells. Paper presented at: 7th World Biomaterials Congress; Sydney, Australia, May 2004.
37. Clyburn, TA, Winston, L, DePrang, C, Sheth, D, and Ambrose, CG: Weightbearing on an Uncemented Total Hip Arthroplasty: A Prospective Comparison of Weight Bearing as Tolerated vs. Touch Down Only by Subsidence Measurement. Western Orthopaedic Association 68th Annual Meeting, San Fransisco, September 29- October 2, 2004.
38. Clyburn, TA, Adams, B, Ambrose, CG, and Ordonez, R: A Comparative Study of Imageless Navigation vs. Mechanical Alignment in Total Knee Arthroplasty: A Cadaveric Study. Western Orthopaedic Association 68th Annual Meeting, San Fransisco, September 29- October 2, 2004.
39. Keibzak, GM and Ambrose, CG: Axial and Transverse Transmission Quantitative Ultrasound may Selectively Assess Material and Structural Properties of Bone. Poster presented at The American Society for Bone and Mineral Research, Annual Meeting, Seattle, Washington, October 2004.
40. Johnson, EM, Ambrose, CG, Hogan, H, Cody, DD: Use of MicroCT in Comparison with DEXA for Rat Osteoporosis. Poster presented at The American Society for Bone and Mineral Research, Annual Meeting, Seattle, Washington, October 2004.
41. Huang, R, Ambrose, CG, Sullivan, E, and Haynes, R: Functional Significance of BMD in Patients with Osteogenesis Imperfecta. 72nd Annual Meeting of the American Academy of Orthopaedic Surgeons, Washington DC, 2005.
42. Guzel, VB, Aurang, K, Ambrose, CG, Clyburn, TA: Biomechanical Comparison of 1-Pole vs 3-Pole Polyethylene Patellar Implant on Fracture Resistance. 74th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Diego, CA, February 2007.
43. Ambrose, CG, Mika, J, and Terry Clyburn, T: Evaluation of Trabecular Metal Implants and Antibiotic Impregnated Microspheres in Osteomyelitis. 24th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, February 8-9, 2007.
44. Ambrose, CG, Mika, J, Gogola, GR, Culton, LK, Johnson, E, Peralta, IRG, Wilson, LJ: In vivo testing of a bone-selective fullerene: Preliminary Safety and Efficacy Assessment. 24th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, February 8-9, 2007.
45. Ambrose, CG, Kaplan, HB, Winslow, S, Jacob, V, and Wang, Y: Development of an in vitro model for biofilms on orthopaedic implants. 24th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, February 8-9, 2007.
46. Winslow S, Jacob V, Wang Y, Ambrose C, Kaplan H. Development of an In-Vitro Model for Staphylococcus Aureus Biofilms on Orthopaedic Devices. Paper presented at: 4th ASM Conference on Biofilms; Quebec, Canada, March 2007.
47. Richardson M, Chandwani V, Ono K, Johnson E, Kogiso M, Wakame K, Ambrose CG, Martinex-Puig D, Kulkarni A. Dietary Nucleotides and Skeletal Function in a Mouse Model of Accelerated Aging. Paper presented at: European Society for Clinical Nutrition and Metabolism,Prague, Czech republic, 2007.
48. Funk S, Ambrose C, Kaplan H. Development of In-Vitro Biofilm Model for Diabetic Foot Ulcer Infections. Paper presented at: Texas Branch Fall Meeting of the American Society for Microbiology; Sam Houston State University, Texas, November 2007.
49. Jordan M, Ardestani S, Troetscher T, Wanger A, Guo D, Kaplan H, Ambrose C. Development of a Rapid and Sensitive Molecular Diagnostic Test to Identify the Causative Bacteria in Diabetic Foot Ulcer Infections. Paper presented at: Texas Branch Fall Meeting of The American Society for Microbiology; Sam Houston State University, Texas, November 2007.
50. Kulkarni A, Richardson M, Ono K, Chandwani V, Johnson E, Kogiso M, Wakame K, Ambrose C, Martinez-Puig D. Nutritional Nucleotides Improve Bone Integrity in Skeletal Disuse. Paper presented at: American Society for Parenteral and Enteral Nutrition 2008 Annual Conference, Chicago, 2008.
51. Peralta, I, Ambrose, C, and Wilson, L. In Vivo Testing of a Bone-Selective Fullerene: Preliminary Safety and Efficacy Testing. Presented at the 213th Meeting of the Electrochemical Society, Phoenix, Arizona, May 2008.
52. Ambrose C, Ardestani S, Troetscher T, Wanger A, Guo D, Clyburn T, Kaplan H. Identification of Causative Bacteria in Osteomyelitis Using Rapid and Sensitive 16 S rDNA Detection. Paper presented at: The 55th Annual Meeting of the Orthopaedic Research Society; Las Vegas, Nevada, February 2009
53. Johnson, E, Shau, D, Cody, D, Ambrose, CG. Bone Mineral Density Assessment Using Different Techniques. 26th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, February 19-20, 2009.
54. Wagenheim, GN, Alam, S, Ambrose, CG, Sen, M, Dickson, KF. Mortality in Patients with Unilateral and Bilateral Femur Fractures, Presented at 2010 American Academy of Orthopaedic Surgeons Meeting, March 2010, New Orleans.
55. Mika J, Clanton TO, Kinne RW, Ambrose CG. Surgical Preparation for Articular Cartilage Regeneration in Patients with Osteoarthritis. Presented at the International Cartilage Repair Society, September 26-29, 2010, Barcelona.
56. Broyles J, Wagenhein G, Alam S, Ambrose C, and Sen M. A High Ratio of Fresh Frozen Plasma to Packed Red Blood Cells Significantly Decreases Mortality in Femur Fracture Patients Requiring Massive Transfusion. Presented at Orthopaedic Trauma Association Annual Meeting, October 13-16, 2010, Baltimore.
57. Pham T., Shaw J, Kaplan H, Sen M, Ambrose CG. Examination of the Eradication of Existing Staphylococcus aureus Biofilms by Exposure to Silver Nanodressing in an In Vitro Infection Model. Poster presented at the Texas Branch Spring Meeting of the American Society for Microbiology; Sam Houston State University, Texas, March 2011.
58. Stover B, Vaksman Z, Kaplan H, Ambrose CG, and Sen M. Testing for Contrasting Infection Rates and Biofilm Formation among Biomaterials in an in vitro Biofilm Infection Model. Paper presented at the 2011 Annual Meeting of the Orthopaedic Trauma Association, San Antonio, Texas, October 2011.
59. Ambrose CG, Miranda J, Gogola GR, Gomez K, Kaplan HB. Persistence of Bacterial DNA in Orthopaedic Infections. Poster presented at the 2012 Annual Meeting of the Orthopaedic Research Society, San Francisco, February 2012.
60. Shaw J, Kaplan H, Sen M, and Ambrose CG. Efficacy of Silver Nanodressing in Eradication of Staphylococcus aureus Biofilms. Poster presented at the 2012 Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA, February 2012.
61. Dominy DD, Ambrose CG, Shaw J, Stover B, Vaksman Z, Kaplan H, and Sen M. Hydrosurgery as an Adjunct to Remove Bacteria from Orthopaedic Biomaterials. Poster presented at the 2012 Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA, February 2012.
62. Andrade F, Ambrose CG, Vaksman Z, Graham CE, Cheng Y, Kaplan HB. Staphylococcus aureus Biofilm Disassembly by Exogenous Hyaluronidase in an In Vitro Osteomyelitis Biofilm Model. Paper presented at the 2012 Biofilms Conference of the American Society for Microbiology, Miami, Sept 29-Oct-4, 2012.
63. Graham C, Vaksman Z, Gomez K, Vega-Arroyo M, Kim Y, Arvidson, R, Luttge A, Ambrose CG, Tribble G, Taylor SR, Kaplan HB. Effects of Sucrose Exposure on the Population Dynamics of an In Vitro Four-Species Cariogenic Biofilm Model. Paper presented at the 2012 Biofilms Conference of the American Society for Microbiology, Miami, Sept 29-Oct-4, 2012.
64. S.R. Taylor, F. Contu, M. Vega-Arroyo, S.K. Mondal, C.G. Ambrose, H.B. Kaplan, F. Andrade, M.J. Hicks, A. Luttge, R.S. Arvidson. “The Role of Biofilm and the Micro-gap on the Development of Secondary Caries”, (invited) International Association of Dental Research, Seattle, WA, March 20-23, 2013.

Refereed Original Articles in Journals:
1. Ambrose, CG, Hayes, LJ, Dulikravich, GS: An Active Control System for Thermal Fields in Hypothermia Processes. American Institute of Chemical Engineers 85(269):400-405, 1989.
2. Ward, LD, Ambrose, CG, Masson, MV, Levaro, F: The Role of the Distal Radioulnar Ligaments, Interosseous Membrane and Joint Capsule in DRUJ Stability. Journal of Hand Surgery, 25A:341-351, 2000.
3. Ambrose, CG, Kiebzak, GM, Sabonghy, EP, Tabor, OB, Peindl, RD, Clanton, TO, Anderson, RA, Davis, WH. Biomechanical Testing of Cadaveric Specimens: Importance of Bone Mineral Density Assessment. Foot and Ankle International, 23(9):850-855, 2002.
4. Kiebzak, GM, Beinart, GA, Perser, K, Ambrose, CG, Siff, SJ, Heggeness, M H. Undertreatment of Osteoporosis in Men with Hip Fractures. Archives of Internal Medicine, 162(19):2217-2222, 2002.
5. Bancroft, GN, Sikavitsas, VI, van den Dolder, J, Sheffield, TL, Ambrose, CG, Jansen, JA, and Mikos, AG. Fluid Flow Increases Mineralized Matrix Deposition in Three-Dimensional Perfusion Culture of Marrow Stromal Osteoblasts in a Dose-Dependent Manner, Proc Natl Acad Sci USA, 99(20):12600-5, 2002.
6. Timmer, MD, Jo, S, Wang, C, Ambrose, CG, Mikos, AG. Characterization of the Cross-Linked Structure of Fumerate-Based Degradable Polymer Networks, Macromolecules 35:4373-4379, 2002.
7. Glauser, CR, Oden, ZM, Ambrose, CG, Willits, MB, and Coupe, KJ. Mechanical Testing of Small Fracture Implants for comparison of Insertion and Failure Torques. Archives Orthopedic and Trauma Surgery, 123:388-391, 2003.
8. Timmer, MD, Carter, C, Ambrose, CG, Mikos, AG. Fabrication of poly(propylene fumarate) – based orthopaedic implants by photo-crosslinking through transparent silicone molds. Biomaterials, 24(25):4707-14, 2003.
9. Timmer, MD, Shin, H, Horch, RA, Ambrose, CG, Mikos, AG. In vitro cytotoxicity of injectable and biodegradable poly (propylene fumarate) – based networks: Unreacted macromers, cross-linked networks, and degradation products, Biomacromolecules, 4(4):1026-33, 2003.
10. Timmer MD, Horch RA, Ambrose CG, Mikos AG. Effect of Physiologic Temperature on the Mechanical Properties and Network Structure of Biodegradable Poly(Proplyene Fumerate)-Based Networks. Journal of Biomaterials Science, Polymer Edition, 14(4):369-82, 2003.
11. Timmer M, Ambrose C, Mikos A.: Evaluation of Thermal- and Photo-Crosslinked Biodegradable Poly(Propylene Fumarate)-Based Networks. Journal of Biomedical Materials Research, 66A(4):811-8, 2003.
12. Ambrose CG, Gogola GR, Clyburn TA, Raymond AK, Peng AS, and Mikos AG. Antibiotic Microspheres: Preliminary Testing for Potential Treatment of Osteomyelitis, Clinical Orthopaedics and Related Research, 415:279-285, 2003.
13. Sabonghy, P., Wood, RM, Ambrose, C., McGarvey, WC, Clanton, TO. Tendon Transfer Fixation: Comparing a tendon to tendon technique vs. bioabsorbable interference-fit screw fixation. Foot and Ankle International, 24(3):260-262, 2003.
14. Clyburn, T.A., Weitz-Marshall, A., and Ambrose, C.G.: “Constrained Acetabular Cups: A Cadaveric Biomechanical Evaluation”. Journal of Arthroplasty, 18(4):466-70, Jun 2003.
15. Timmer, MD, Ambrose, CG, Mikos, AG. In Vitro Degradation of Polymeric Networks of Poly(Propylene Fumerate) and the Crosslinking Macromer Poly(Propylene Fumerate)-Diacrylate. Biomaterials, 24(4):571-577, 2003.
16. Louden, KW, Ambrose, CG, Beaty, SG, McGarvey, WC, Clanton, TO. Tendon Transfer Fixation in the Foot and Ankle: A Biomechanical Study Evaluating Two Sizes of Pilot Holes for Bioabsorbable Screws. Foot and Ankle International, 24(1):67-72, 2003.
17. D.S. Sheth, D. Oldfield, C. Ambrose, T. Clyburn. Total Knee Arthroplasty in Hemophilia. Journal of Arthroplasty, 19(1):56-50, January 2004.
18. Ambrose, RO and Ambrose, C. Primate Anatomy, Kinematics and Principles for Humanoid Design. International Journal of Humanoid Robotics, 1:175-198, 2004.
19. Ambrose, CG, Clanton, TO. Bioabsorbable implants: Review of clinical experience in orthopaedic surgery. Annals of Biomedical Engineering, 32(1):171-177, 2004.
20. Ambrose, CG, Clyburn, TA, Louden, K, Joseph, J, Wright, J, Gulati, P, Gogola, GR, Mikos, GA. Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clinical Orthopaedics and Related Research, 421:293-299, 2004.
21. Temenoff, JS, Park, H, Jabbari, E, Conway, DE, Sheffield, TL, Ambrose, CG, and Mikos, AG: Thermally Cross-Linked Oligo(poly(ethylene glycol)fumerate) Hydrogels Support Osteogenic Differentiation of Encapsulated Marrow Stromal Cells in Vitro. Biomacromolecules, 5:5-10, 2004.
22. Temenoff, JS, Park, H, Jabbari, E, Sheffield, TL, LeBaron, RG, Ambrose, CG, and Mikos, AG: In-Vitro Osteogenic Differentiation of Marrow Stromal Cells Encapsulated in Biodegradable Hydrogels. Journal Biomed Mat Res Part A, 70A(2):235-244, 2004.
23. Warnock, KM, Johnson, BD, Wright, JB, Ambrose, CG, Clanton, TO, and McGarvey, WC: Calculation of the Opening Wedge for a Low Tibial Osteotomy. Foot and Ankle International, 25(11):778-782, 2004.
24. Holtorf, HL, Sheffield, TL, Ambrose, CG, Jansen, JA, and Mikos, AG: Flow Perfusion Culture of Marrow Stromal Cells Seeded on Porous Biphasic Calcium Phosphate Ceramics. Annals of Biomedical Engineering 33(9):1238-48, Sept. 2005.
25. Kiebzak, GM, and Ambrose, CG: Relationship Among MRTA, DXA, and QUS Revisited, Journal of Clinical Densitometry, 8(4):396-403, 2005.
26. Kendler DL, Kiebzak GM, Ambrose CG, et al. Effect of calcium tablets on interpretation of lumbar spine DXA scans. J Clin Densitom.9(1):97-104, 2006.
27. Huang RP, Ambrose CG, Sullivan E, Haynes RJ. Functional significance of bone density measurements in children with osteogenesis imperfecta. J Bone Joint Surg Am. 88(6):1324-1330, 2006.
28. Elkousy, H, Hammerman, SM, Edwards, TB, Warnock, KM, O’Connor, DP, Ambrose, C, Meyers, D, Gartsman, GM. The arthroscopic square knot: A biomechanical comparison with open and arthroscopic knots. Arthroscopy 22(7):736-741, 2006.
29. Clyburn T, Weitz-Marshall A, Ambrose C, Ursua V. Outcomes of patellofemoral replacement in total knee arthroplasty using meticulous techniques. Orthopedics 30(2):111-115, 2007.
30. Mika J, Clanton TO, Pretzel D, Schneider G, Ambrose CG, Kinne RW. Surgical Preparation for Articular Cartilage Regeneration without Penetration of the Subchondral Bone Plate: In Vitro and In Vivo Studies in Human & Sheep. Am J Sports Med, 39(3):624-631, 2011.
31. Budoff JE, Meyers DM, and Ambrose CG. The Comparative Stability of Screw Versus Plate Versus Screw and Plate Coronoid Fixation. J Hand Surg, 36(2):238-245, 2011.
32. Banks KE, Ambrose CG, Wheeless JS, Tissue CM, and Sen M. An Alternative Patellar Fracture Fixation: A Biomechanical Study. J Ortho Trauma: 27(6):345-51, 2013.
33. Clanton TO, Matheny LM, Jarvis HC, Lewis EV, and Ambrose CG. Quantitative analysis of torsional stiffness in supplemental one-third tubular plate fixation in the management of isolated syndesmosis injuries - a biomechanical study. Foot and Ankle Int, 34(2):267-72, 2013.
34. Yang T, Grafe I, Bae Y, Chen S, Chen Y, Bertin TK, J M-M, Ambrose CG, Lee B. E-Selectin Ligand 1 regulates bone remodeling by limiting TGF-β bioavailability in the bone microenvironment. Proc Natl Acad Sci USA, 110(18):7336-41, 2013.
1. Ambrose CG, Clyburn TA, Mika J, Gogola GR, Kaplan HB, Wanger a, Mikos AG. Evaluation of Antibiotic Impregnated Microspheres for the Prevention of Implant-Associated Orthopaedic Infections. J Bone Joint Surg, in press.

Book Chapters:
1. Ambrose, CG, Sharif, A, Diller, KR, and Hayes, LJ. A Numerical Design Methodology for a VLSI Cryostage, in Computational Methods in Bioengineering, Spilker, RL and Simon, BR, editors, 1988.
2. Katz, JL, Ambrose, CG, McMillin, CR, and Spencer, P. Orthopaedic Biomaterials, in Encyclopedia of Biomaterials and Biomedical Engineering, Wnek, GE and Bowlin, GL, editors, 2004.
3. Ambrose CG and Hogan H. Ex Vivo Testing of Orthopaedic Implants, in Orthopaedic Implants: Applications, Complications, and Management, Lindsey, RW and Gugala, Z, editors, in press.

Letters to the Editor:
1. Kiebzak, GM, Beinart, GA, Perser, K, Ambrose, CG, Siff, SJ, Heggeness, MH : “Undertreatment of Osteoporosis in Men who have had a Hip Fracture – Reply”. Archives of Internal Medicine 163(190):1236-1237, 2003.
2. Kiebzak, GM, Beinart, GA, Perser, K, Ambrose, CG, Siff, SJ, Heggeness, MH : “Hypogonadism and Osteoporosis in Men – Reply”. Archives of Internal Medicine 163(190):1237-1238, 2003.
3. Ambrose, C. and Gogola G: The Effect of NSAIDs on Fracture Healing, Journal of Bone and Joint Surgery published electronically March 2005, www.jbjs.org.
4. Sheth DS and Ambrose CG: Stress Test for Predicting the Need for Surgical Fixation of Fibular Fractures, Journal of Bone and Joint Surgery 87(5A):1165, 2005.

Achievements

Nominated for the President's Mentoring Award for Faculty, UTHSC-Houston, 2004 and 2011.
Kiebzak GM, Beinart GA, Perser K, Ambrose C, Siff SJ, Heggeness MH: Undertreatment of osteoporosis in men with hip fracture. Outstanding Clinical Abstract at the Annual Meeting of the International Society for Clinical Densitometry, Atlanta, GA 2002.
Supervisor, Mark Timmer, recipient of a Natural Sciences and Engineering Research Council Fellowship, 2000-2002
Supervisor, Gloria Gogola, finalist for the Smith and Nephew Resident Research Award, 1998.
Tau Beta Pi- National Engineering Honor Society, 1987.
BSME cum laude- Washington University, 1987.
Pi Tau Sigma- National Mechanical Engineering Honor Society, 1986.
Jerome J. Spector Memorial Scholarship - 1985-1987.
National Merit Scholar- 1983-1987.

OTHER PROFESSIONAL ACTIVITY:
Ad Hoc Reviewer for the following journals:
• Acta Biomaterialia
• Annals of Biomedical Engineering
• Experimental Mechanics
• Foot and Ankle International
• Journal of Antimicrobial Chemotherapy
• Journal of the American Medical Association
• Journal of Biomedical Materials Research: Part A
• Journal of Orthopedic Research
• Osteoporosis International
• IEEE Transactions on Mechatronics

Grant reviewer for the following programs:
• Ad Hoc Reviewer for Skeletal Biology, Development and Disease Study Section for the National Institutes of Health, 2008-present
• Reviewer for Special Emphasis Panel for the National Institutes of Health, 2009
• The National Academies, National Research Council, Committee to Review Proposals to the Ohio Third Frontier (OTF)
Wright Projects Program (WPP), 2011. Committee to Review Proposals Ohio Third Frontier Innovation Platform Program (IPP), 2012-2013.
• National Science Foundation, SBIR/STTR Materials for Biomedical Applications Panel, 2011
• American Osteopathic Association Council on Research
• Multidisciplinary Research Grants Program for the North Carolina Biotechnology Center
• South Carolina Experimental Program to Stimulate Competitive Research (EPSCoR) and Institutional Development Awards (IDeA) programs
Reviewer National Student Research Forum 2012, 2013
US Patent 8,261,949, Adjustable Volume Liquid Dispensing Pump
US Patent Pending, Biodegradable Microspheres for Antibiotic Drug Delivery
Patent granted: Australia, New Zealand, South Africa, European
Union, India, Mexico, Canada

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