Biography

Dr. Catherine Ambrose is an Associate Professor in the Department of Orthopedic Surgery at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth). She also serves as the Director of the Biomechanics Laboratory, the Bone Histomorphometry Laboratory, and the Bone Denistometry Laboratory for the Department of Orthopedic Surgery. Dr. Ambrose is also an Adjunct Associate Professor in Biomedical Engineering at Rice University.

Dr. Ambrose received her undergraduate degree in Mechanical Engineering from Washington University in Saint Louis, Missouri. She went on to complete both a Masters of Science in Biomechanical Engineering and her Ph.D. in Mechanical Engineering from the University of Texas at Austin in Austin, Texas.

Education

Undergraduate Degree
Washington University, Saint Louis, Missouri
Masters Degree
Masters of Science, The University of Texas at Austin, Austin, Texas
Doctoral Degree
The University of Texas at Austin, Austin, Texas

Areas of Interests

Research Interests

CURRENT GRANT SUPPORT:
Title: “The Role of Biofilm on Margin Stability and the Development of Secondary Caries”
Source: The National Institute of Dental and Craniofacial Research
PI: S. Ray Taylor, PhD
Co-I:Catherine Ambrose, PhD and Heidi Kaplan, PhD
9/1/2010-8/31/2014 $1,519,214

Title: “Resident and Fellow Research and Education”
Source: Zimmer, Inc
PI: Catherine Ambrose, Ph.D.
Co-PI: Dhiren Sheth, MD.
8/05/05-12/31/20 $50,000

PAST GRANT SUPPORT: Title: “Testing for Contrasting Infection Rates and Biofilm Formation Among Biomaterials in an in vitro Biofilm Infection Model”
Source: Stryker, Inc
PI: Catherine Ambrose, PhD
Co-I:Milan Sen, MD and Heidi Kaplan
1/1/2010-6/30/11 $32,486

Title: “PC-NSAIDs: Gastrointestinal-safe and potent anti-inflammatory drugs”
Source: US Army SBIR Phase II
PI: PLX-Pharma
Subcontract: Catherine Ambrose, PhD ($34,905 per year)
11/25/08-12/24/10 $729,991.79

Title: “Bioengineering Masters Degree Program”
Source: Encore Medical
PI: Alex Rosenstein, MD
Co-PI: Catherine Ambrose, PhD
7/1/2008-6/30/2010 $153,166

Title: “Identification of Causative Bacteria in Osteomyelitis Using Rapid and Sensitive 16SrRNA Detection”
Source: Orthopedic Research & Education Foundation
PI: Catherine Ambrose, PhD
Co-I: Terry Clyburn, MD, Heidi Kaplan, PhD
7/01/07-6/30/10 $150,000

Title: “PC-NSAIDs: Gastrointestinal-safe and potent anti-inflammatory drugs”
Source: US Army SBIR Phase I
PI: PLX-Pharma
Subcontract: Catherine Ambrose, PhD ($7700)
11/11/07-6/10/08 $69,997.08

Title: “Biomechanical Evaluation of Anatomic Contoured Locking Plates for Periarticular Fractures”
Source: Zimmer, Inc
PI: Catherine Ambrose, PhD
Co-I: Dhiren Sheth, MD
8/15/05-8/15/07 $80,947

Title: “Evaluation of Trabecular Metal Implants and Biodegradable Microspheres Impregnated with BMP2”
Source: Zimmer, Inc
PI: Catherine Ambrose, PhD
Co-I: Dhiren Sheth, MD
4/16/06-12/19/07 $214,633

Title: “Evaluation of Trabecular Metal Implants and Antibiotic Impregnated Microspheres in Osteomyelitis ”
Source: Zimmer, Inc
PI: Catherine Ambrose, Ph.D.
Co-PI: Terry Clyburn, M.D.
7/01/05-7/27/07 $119,770

Title: “Effects of NSAIDs on Osteointegration – Continuing Studies”
Source: Zimmer, Inc
PI: Catherine Ambrose, Ph.D.
Co-PI: Dhiren Sheth, MD.
7/01/05-7/27/07 $88,615

Title: “Effects of NSAIDs on Osteointegration”
Source: Zimmer, Inc
PI: Catherine Ambrose, PhD

Publications

Publication Information

Abstracts

Ambrose, C.G.: Graphical Simulation Environment for Locomotion Analysis, 12th Annual Houston Conference on Biomedical Engineering Research, Houston, February 1994.

Ambrose, C.G., Daum, W.J., and Solvelius, P.E.: A Comparison of Contouring Techniques for Locating Bony Landmarks Using MR and CT Imaging, 13th Annual Houston Conference on Biomedical Engineering Research, Houston, February, 1995.

Ambrose, C.G., Daum, W.J., Solvelius, P.E., Kulkarni, M., and Kaufman, B.: Validation of Bony Landmarks Derived From 3-D reconstructions of MR and CT Images, Transactions of the 41st Annual Meeting of the Orthopedic Research Society, Volume 2:800, Atlanta, 1995.

Ambrose, R.O., and Ambrose, C.G.: Robot Models for Space Environments. Proceedings of the 1995 IEEE International Conference on Robotics and Automation, May 1995.

Ambrose, C.G., Reuben, J.D., and Andreo, M.A.: Automatic Measurement System for Orthopedic Applications – Total Hip Arthroplasty and Patello-Femoral Kinematics, Annual Fall Meeting of the Biomedical Engineering Society, Boston, 1995.

Kramer, R.C., Masson, M.V., and Ambrose, C.G.: The Effect of Wrist, MP and IP Joint Position on Extensor Tendon Tension, Annual Meeting of the American Association of Orthopedic Surgeons, Atlanta, Georgia, 1996.

Ambrose, C.G. and Ambrose, R.O.: Non-Invasive Motion Measurement for Orthopedic Kinematic Measurements, 14th Annual Houston Conference on Biomedical Engineering Research, Houston, February 1996.

Ambrose, R.O., and Ambrose, C.G.: Kinetics of Two-Handed Climbing Gaits in Zero Gravity, 14th Annual Houston Conference on Biomedical Engineering Research, Houston, February 1996.

Ambrose, C.G., Ward, L., Masson, M., and Lavarro, F.: Viscoelastic Models of the Distal Radio-Ulnar Joint, 15th Annual Houston Conference on Biomedical Engineering Research, Houston, February, 1997.10.

Hogan, H., Lin, C., Ambrose, C.G., Evans, H., Harrigan, T., Shackelford, L., and LeBlanc, A.: Relations Between Trabecular Bone Properties and MRI Relaxation Times, ASME IMECE97 Bioengineering Division Meeting, Dallas, Texas, November 16-21, BED Vol 36:325-326, 1997.

Ambrose, C.G., Brennan, M., and Gogola, G.R.: Correlation of Mechanical Strength with Bone Loss in Ovariectomized Rat Model, Transactions of the Forty-Fourth Annual Meeting of the Orthopedic Research Society, New Orleans, 1998.

Ambrose, C.G., Gogola, G.R., Brennan, M.S.: The Effect of NSAIDs and Correlation of Mechanical Strength in Hormone-Deficient Osteoporosis, 16th Annual Houston Conference on Biomedical Engineering Research, Houston, April 1998.

Ambrose, C.G., Gogola, G.R., Stancel, G.: Musculoskeletal Effects of Neonatal Exposure to Natural and Synthetic Estrogens, 17th Annual Houston Conference on Biomedical Engineering Research, Houston, 1999.

Gogola, G.R., Ambrose, C.G., Mikos, A., Peng, A.: PLGA/PEG Microspheres as an Antibiotic Delivery System for Osteomyelitis, 17th Annual Houston Conference on Biomedical Engineering Research, Houston, 1999.

Timmer, M.D., He, S., Mikos, A.G., Ambrose, C.G.: Investigation of a Poly(Propylene Fumerate)-Based Polymer for Bioresorbable Interbody Fusion Cage, 18th Annual Houston Conference on Biomedical Engineering Research, Houston, 2000.

Gogola, G., Ambrose, C.G., Peng, A., Mikos, A.: PLGA/PEG Microspheres as an Antibiotic Delivery System, 46th Annual Meeting of the Orthopedic Research Society, Orlando, FL, March 11-14, 2000.

Ambrose, C.G, Meyers, N., Beaver, R., Clyburn, T.A.: Evaluation of Resorbable Ceramic Bone Void Fillers Using a Critical-Size Defect in a Sheep Model, 18th Annual Houston Conference on Biomedical Engineering Research, Houston, 2000.

Ambrose, C.G., Gogola, G., and Brennan, M.: The Effects of Indomethacin and Ibuprofen on Hormone-Deficient Bone Density Loss in an Ovariectomized Mature Rat Model, the World Congress on Osteoporosis 2000, Chicago, Osteoporosis International 11(Suppl 2):S170-S171, June 2000.

Sabonghy, P., Ambrose, C.A., Wood, R.M., Clanton, T.O.: Tendon Transfer Fixation in the Foot and Ankle: Biomechanical Comparison of a Traditional Fixation Technique Verses Bioabsorbable Interference-Fit Screw Fixation, American Academy of Orthopedic Surgeons Annual Meeting, San Francisco, 2001.

Louden, K.W., Beaty, S.G., Clanton, T.O., Ambrose, C.G.: Tendon Transfer Fixation in the Foot and Ankle: A Biomechanical Study Evaluating Two Sizes of Bioabsorbable Screws, 19th Annual Houston Conference on Biomedical Engineering Research, Houston, 2001.

Clubb F, Peterson M, Coscio M, Ambrose C, Wolff R, Rossi A, Sedlik S, Rose B, Urban J, Buja M, McClay C. The Use of Integrated microscopicTechniques for Analyzing Implanted Vascular Stents. 21st Annual S&T Conference, 2001.

Timmer, M.D., Ambrose, C.G., Mikos, A.G.: Quantification of the Crosslinking Density of Poly(Propylene Fumerate)-Based Biodegradable Networks, American Institute of Chemical Engineers Fall Meeting, 2001.

Timmer, M.D., He, S., Ambrose, C.G., Mikos, A.G.: Mechanical Properties of Photo-Initiated Biodegradable Polymer Networks for Prefabricated Orthopedic Scaffolds, Society for Biomaterials Annual Meeting, 2001.

Guzel VB, Kent M, Ambrose C, Koeck W, Schults J, Coupe KJ: Biomechanical Evaluation of Internal Fixation Techniques in Unstable Intertrochanteric Femur Fractures. The 8th Meeting of the International Society for Fracture Repair, Toronto, Ontario, Canada; 2002.

Kiebzak GM, Beinart GA, Perser K, Ambrose C, Siff SJ, Heggeness MH: Undertreatment of osteoporosis in men with hip fracture. Poster presentation at the Annual Meeting of the International Society for Clinical Densitometry, Atlanta, GA, 2002. Journal of Clinical Densitometry 5 (Supplement): S47. This presentation won the “Outstanding Clinical Abstract” award.

Ambrose CG, Kiebzak GM, Tabor OB, Peindl RD, Anderson RB, Davis WH, Clanton TO: Biomechanical testing of cadaveric specimens: importance of bone mineral density assessment. Poster presentation at the Annual Meeting of the International Society for Clinical Densitometry, Atlanta, GA, 2002. Journal of Clinical Densitometry 5 (Supplement): S47.

Guzel, V., Kent, M., Ambrose, C, Meyers, N. and Coupe, K: Biomechanical Evaluation of Internal Fixation Techniques in Unstable Intertrochanteric Femur Fractures. 20th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, April 4, 2003.

Lemmon, H, Johnson, E, Cody, DD, Ambrose, CG, and Hogan, HA: Regional Variations in Cancellous BMD Within the Distal Metaphysis of the Rat Femur. American Society for Bone and Mineral Research, 2003 Annual Meeting, Minneapolis, Minnesota, Journal of Bone and Mineral Research 18(supplement2):S206-S207, 2003.

Clyburn, TA, Ambrose, CG, and Weitz-Marshall: Constrained Acetabulum – A Biomechanical, Cadaver-Model Study. 67th Annual Western Orthopedic Association Annual Meeting, San Antonio, October 2003.

Clyburn, TA and Ambrose , CG: Antibiotic Microspheres for the Treatment and Prevention of Orthopedic Infections. 67th Annual Western Orthopedic Association Annual Meeting, San Antonio, October 2003.

Clyburn, TA and Ambrose, CG: Cement Injection into the Femur – An Improved Technique. 67th Annual Western Orthopedic Association Annual Meeting, San Antonio, October 2003.

Martin, S, Kiebzak, GM, Ambrose, CG: Fracture Risk Assessment Discrepancy Among Three Quantitative Ultrasound Systems. International Society for Clinical Densitometry, 2004 Annual Meeting, Miami Florida, Journal of Clinical Densitometry 7(2):248, 2004.

Kiebzak, GM, Martin, S., and Ambrose, CG: Comparing Precision Values: Impact of Study Design and Statistical Techniques. International Society forClinical Densitometry, 2004 Annual Meeting, Miami Florida, Journal of Clinical Densitometry 7(2):248, 2004

Kiebzak, GM, Ambrose, CG, Schmeer, P: Insoluble Intestinal Calcium Complexes May Affect Monitoring but Not Diagnosis. International Society for Clinical Densitometry, 2004 Annual Meeting, Miami Florida, Journal of Clinical Densitometry 7(2):239, 2004

Huang, RP, Ambrose, CG, Sullivan, E., Haynes, R.J.: Functional Significance of DEXA Measurements in Patients with Osteogenesis Imperfecta. Poster presentation at the Pediatric Orthopedic Society of North America (POSNA) Annual Meeting, St. Louis, MO, April 29, 2004.

Clyburn, TA, Winston, L, DePrang, C, Sheth, D, and Ambrose, CG: Weightbearing on an Uncemented Total Hip Arthroplasty: A Prospective Comparison of Weight Bearing as Tolerated vs. Touch Down Only by Subsidence Measurement. Western Orthopedic Association 68th Annual Meeting, San Fransisco, September 29- October 2, 2004.

Clyburn, TA, Adams, B, Ambrose, CG, and Ordonez, R: A Comparative Study of Imageless Navigation vs. Mechanical Alignment in Total Knee Arthroplasty: A Cadaveric Study. Western Orthopedic Association 68th Annual Meeting, San Fransisco, September 29- October 2, 2004.

Keibzak, GM and Ambrose, CG: Axial and Transverse Transmission Quantitative Ultrasound may Selectively Assess Material and Structural Properties of Bone. Poster presented at The American Society for Bone and Mineral Research, Annual Meeting, Seattle, Washington, October 2004.

Johnson, EM, Ambrose, CG, Hogan, H, Cody, DD: Use of MicroCT in Comparison with DEXA for Rat Osteoporosis. Poster presented at The American Society for Bone and Mineral Research, Annual Meeting, Seattle, Washington, October 2004.

Huang, R, Ambrose, CG, Sullivan, E, and Haynes, R: Functional Significance of BMD in Patients with Osteogenesis Imperfecta. 72nd Annual Meeting of the American Academy of Orthopedic Surgeons, Washington DC, 2005.

Guzel, VB, Aurang, K, Ambrose, CG, Clyburn, TA: Biomechanical Comparison of 1-Pole vs 3-Pole Polyethylene Patellar Implant on Fracture Resistance. 74th Annual Meeting of the American Academy of Orthopedic Surgeons, San Diego, CA, February 2007.

Ambrose, CG, Mika, J, and Terry Clyburn, T: Evaluation of Trabecular Metal Implants and Antibiotic Impregnated Microspheres in Osteomyelitis. 24th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, February 8-9, 2007.

Ambrose, CG, Mika, J, Gogola, GR, Culton, LK, Johnson, E, Peralta, IRG, Wilson, LJ: In vivo testing of a bone-selective fullerene: Preliminary Safety and Efficacy Assessment. 24th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, February 8-9, 2007.

Ambrose, CG, Kaplan, HB, Winslow, S, Jacob, V, and Wang, Y: Development of an in vitro model for biofilms on orthopedic implants. 24thAnnual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, February 8-9, 2007.

Winslow S, Jacob V, Wang Y, Ambrose C, Kaplan H. Development of an In-Vitro Model for Staphylococcus Aureus Biofilms on Orthopedic Devices. Paper presented at: 4th ASM Conference on Biofilms; Quebec, Canada, March 2007.

Richardson M, Chandwani V, Ono K, Johnson E, Kogiso M, Wakame K, Ambrose CG, Martinex-Puig D, Kulkarni A. Dietary Nucleotides and Skeletal Function in a Mouse Model of Accelerated Aging. Paper presented at: European Society for Clinical Nutrition and Metabolism,Prague, Czech republic, 2007.

Funk S, Ambrose C, Kaplan H. Development of In-Vitro Biofilm Model for Diabetic Foot Ulcer Infections. Paper presented at: Texas Branch Fall Meeting of the American Society for Microbiology; Sam Houston State University, Texas, November 2007.

Jordan M, Ardestani S, Troetscher T, Wanger A, Guo D, Kaplan H, Ambrose C. Development of a Rapid and Sensitive Molecular Diagnostic Test to Identify the Causative Bacteria in Diabetic Foot Ulcer Infections. Paper presented at: Texas Branch Fall Meeting of The American Society for Microbiology; Sam Houston State University, Texas, November 2007.

Kulkarni A, Richardson M, Ono K, Chandwani V, Johnson E, Kogiso M, Wakame K, Ambrose C, Martinez-Puig D. Nutritional Nucleotides Improve Bone Integrity in Skeletal Disuse. Paper presented at: American Society for Parenteral and Enteral Nutrition 2008 Annual Conference, Chicago, 2008.

Peralta, I, Ambrose, C, and Wilson, L. In Vivo Testing of a Bone-Selective Fullerene: Preliminary Safety and Efficacy Testing. Presented at the 213th Meeting of the Electrochemical Society, Phoenix, Arizona, May 2008.

Ambrose C, Ardestani S, Troetscher T, Wanger A, Guo D, Clyburn T, Kaplan H. Identification of Causative Bacteria in Osteomyelitis Using Rapid and Sensitive 16 S rDNA Detection. Paper presented at: The 55th Annual Meeting of the Orthopedic Research Society; Las Vegas, Nevada, February 2009

Johnson, E, Shau, D, Cody, D, Ambrose, CG. Bone Mineral Density Assessment Using Different Techniques. 26th Annual Meeting of the Houston Society for Engineering in Medicine and Biology, Houston, February 19-20, 2009.

Wagenheim, GN, Alam, S, Ambrose, CG, Sen, M, Dickson, KF. Mortality in Patients with Unilateral and Bilateral Femur Fractures, Presented at 2010 American Academy of Orthopedic Surgeons Meeting, March 2010, New Orleans.

Mika J, Clanton TO, Kinne RW, Ambrose CG. Surgical Preparation for Articular Cartilage Regeneration in Patients with Osteoarthritis. Presented at the International Cartilage Repair Society, September 26-29, 2010, Barcelona.

Broyles J, Wagenhein G, Alam S, Ambrose C, and Sen M. A High Ratio of Fresh Frozen Plasma to Packed Red Blood Cells Significantly Decreases Mortality in Femur Fracture Patients Requiring Massive Transfusion.Presented at Orthopedic Trauma Association Annual Meeting, October 13-16, 2010, Baltimore.

Pham T., Shaw J, Kaplan H, Sen M, Ambrose CG. Examination of the Eradication of Existing Staphylococcus aureus Biofilms by Exposure to Silver Nanodressing in an In Vitro Infection Model. Poster presented at the Texas Branch Spring Meeting of the American Society for Microbiology; Sam Houston State University, Texas, March 2011.

Stover B, Vaksman Z, Kaplan H, Ambrose CG, and Sen M. Testing for Contrasting Infection Rates and Biofilm Formation among Biomaterials in an in vitro Biofilm Infection Model. Paper presented at the 2011 Annual Meeting of the Orthopedic Trauma Association, San Antonio, Texas, October 2011.

Ambrose CG, Miranda J, Gogola GR, Gomez K, Kaplan HB. Persistence of Bacterial DNA in Orthopedic Infections. Poster presented at the 2012 Annual Meeting of the Orthopedic Research Society, San Francisco, February 2012.

Shaw J, Kaplan H, Sen M, and Ambrose CG. Efficacy of Silver Nanodressing in Eradication of Staphylococcus aureus Biofilms. Poster presented at the 2012 Annual Meeting of the American Academy of Orthopedic Surgeons, San Francisco, CA, February 2012.

Dominy DD, Ambrose CG, Shaw J, Stover B, Vaksman Z, Kaplan H, and Sen M. Hydrosurgery as an Adjunct to Remove Bacteria from Orthopedic Biomaterials. Poster presented at the 2012 Annual Meeting of the American Academy of Orthopedic Surgeons, San Francisco, CA, February 2012.

Andrade F, Ambrose CG, Vaksman Z, Graham CE, Cheng Y, Kaplan HB. Staphylococcus aureus Biofilm Disassembly by Exogenous Hyaluronidase in an In Vitro Osteomyelitis Biofilm Model. Paper presented at the 2012 Biofilms Conference of the American Society for Microbiology, Miami, Sept 29-Oct-4, 2012.

Graham C, Vaksman Z, Gomez K, Vega-Arroyo M, Kim Y, Arvidson, R, Luttge A, Ambrose CG, Tribble G, Taylor SR, Kaplan HB. Effects of Sucrose Exposure on the Population Dynamics of an In Vitro Four-Species Cariogenic Biofilm Model. Paper presented at the 2012 Biofilms Conference of the American Society for Microbiology, Miami, Sept 29-Oct-4, 2012.

Refereed Original Articles in Journals:

Ambrose, CG, Hayes, LJ, Dulikravich, GS: An Active Control System for Thermal Fields in Hypothermia Processes. American Institute of Chemical Engineers 85(269):400-405, 1989.

Ward, LD, Ambrose, CG, Masson, MV, Levaro, F: The Role of the Distal Radioulnar Ligaments, Interosseous Membrane and Joint Capsule in DRUJ Stability. Journal of Hand Surgery, 25A:341-351, 2000.

Ambrose, CG, Kiebzak, GM, Sabonghy, EP, Tabor, OB, Peindl, RD, Clanton, TO, Anderson, RA, Davis, WH. Biomechanical Testing of Cadaveric Specimens: Importance of Bone Mineral Density Assessment. Foot and Ankle International, 23(9):850-855, 2002.4. K

iebzak, GM, Beinart, GA, Perser, K, Ambrose, CG, Siff, SJ, Heggeness, M H. Undertreatment of Osteoporosis in Men with Hip Fractures. Archives of Internal Medicine, 162(19):2217-2222, 2002.

Bancroft, GN, Sikavitsas, VI, van den Dolder, J, Sheffield, TL, Ambrose, CG, Jansen, JA, and Mikos, AG. Fluid Flow Increases Mineralized Matrix Deposition in Three-Dimensional Perfusion Culture of Marrow Stromal Osteoblasts in a Dose-Dependent Manner, Proceedings of the National Academy of Sciences USA, 99(20):12600-5, 2002.

Timmer, MD, Jo, S, Wang, C, Ambrose, CG, Mikos, AG. Characterization of the Cross-Linked Structure of Fumerate-Based Degradable Polymer Networks, Macromolecules 35:4373-4379, 2002.

Glauser, CR, Oden, ZM, Ambrose, CG, Willits, MB, and Coupe, KJ. Mechanical Testing of Small Fracture Implants for comparison of Insertion and Failure Torques. Archives Orthopedic and Trauma Surgery, 123:388-391, 2003.

Timmer, MD, Carter, C, Ambrose, CG, Mikos, AG. Fabrication of poly(propylene fumarate) – based orthopedic implants by photo-crosslinking through transparent silicone molds. Biomaterials, 24(25):4707-14, 2003.

Timmer, MD, Shin, H, Horch, RA, Ambrose, CG, Mikos, AG. In vitro cytotoxicity of injectable and biodegradable poly (propylene fumarate) – based networks: Unreacted macromers, cross-linked networks, and degradation products, Biomacromolecules, 4(4):1026-33, 2003.

Timmer MD, Horch RA, Ambrose CG, Mikos AG. Effect of Physiologic Temperature on the Mechanical Properties and Network Structure of Biodegradable Poly(Proplyene Fumerate)-Based Networks. Journal of Biomaterials Science, Polymer Edition, 14(4):369-82, 2003.

Timmer M, Ambrose C, Mikos A.: Evaluation of Thermal- and Photo-Crosslinked Biodegradable Poly(Propylene Fumarate)-Based Networks. Journal of Biomedical Materials Research, 66A(4):811-8, 2003.

Ambrose CG, Gogola GR, Clyburn TA, Raymond AK, Peng AS, and Mikos AG. Antibiotic Microspheres: Preliminary Testing for Potential Treatment of Osteomyelitis, Clinical Orthopedics and Related Research, 415:279-285, 2003.

Sabonghy, P., Wood, RM, Ambrose, C., McGarvey, WC, Clanton, TO. Tendon Transfer Fixation: Comparing a tendon to tendon technique vs. bioabsorbable interference-fit screw fixation. Foot and Ankle International, 24(3):260-262, 2003.

Clyburn, T.A., Weitz-Marshall, A., and Ambrose, C.G.: “Constrained Acetabular Cups: A Cadaveric Biomechanical Evaluation”. Journal of Arthroplasty, 18(4):466-70, Jun 2003.

Timmer, MD, Ambrose, CG, Mikos, AG. In Vitro Degradation of Polymeric Networks of Poly(Propylene Fumerate) and the Crosslinking Macromer Poly(Propylene Fumerate)-Diacrylate. Biomaterials, 24(4):571-577, 2003.16.

Louden, KW, Ambrose, CG, Beaty, SG, McGarvey, WC, Clanton, TO. Tendon Transfer Fixation in the Foot and Ankle: A Biomechanical Study Evaluating Two Sizes of Pilot Holes for Bioabsorbable Screws. Foot and Ankle International, 24(1):67-72, 2003.

D.S. Sheth, D. Oldfield, C. Ambrose, T. Clyburn. Total Knee Arthroplasty in Hemophilia. Journal of Arthroplasty, 19(1):56-50, January 2004.

Ambrose, RO and Ambrose, C. Primate Anatomy, Kinematics and Principles for Humanoid Design. International Journal of Humanoid Robotics, 1:175-198, 2004.

Ambrose, CG, Clanton, TO. Bioabsorbable implants: Review of clinical experience in orthopedic surgery. Annals of Biomedical Engineering, 32(1):171-177, 2004.

Ambrose, CG, Clyburn, TA, Louden, K, Joseph, J, Wright, J, Gulati, P, Gogola, GR, Mikos, GA. Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clinical Orthopedics and Related Research, 421:293-299, 2004.

Temenoff, JS, Park, H, Jabbari, E, Conway, DE, Sheffield, TL, Ambrose, CG, and Mikos, AG: Thermally Cross-Linked Oligo(poly(ethylene glycol)fumerate) Hydrogels Support Osteogenic Differentiation of Encapsulated Marrow Stromal Cells in Vitro. Biomacromolecules, 5:5-10, 2004.

Temenoff, JS, Park, H, Jabbari, E, Sheffield, TL, LeBaron, RG, Ambrose, CG, and Mikos, AG: In-Vitro Osteogenic Differentiation of Marrow Stromal Cells Encapsulated in Biodegradable Hydrogels. Journal Biomed Mat Res Part A, 70A(2):235-244, 2004.

Warnock, KM, Johnson, BD, Wright, JB, Ambrose, CG, Clanton, TO, and McGarvey, WC: Calculation of the Opening Wedge for a Low Tibial Osteotomy. Foot and Ankle International, 25(11):778-782, 2004.

Holtorf, HL, Sheffield, TL, Ambrose, CG, Jansen, JA, and Mikos, AG: Flow Perfusion Culture of Marrow Stromal Cells Seeded on Porous Biphasic Calcium Phosphate Ceramics. Annals of Biomedical Engineering 33(9):1238-48, Sept. 2005.

Kiebzak, GM, and Ambrose, CG: Relationship Among MRTA, DXA, and QUS Revisited, Journal of Clinical Densitometry, 8(4):396-403, 2005.

Kendler DL, Kiebzak GM, Ambrose CG, et al. Effect of calcium tablets on interpretation of lumbar spine DXA scans. J Clin Densitom.9(1):97-104, 2006.

Huang RP, Ambrose CG, Sullivan E, Haynes RJ. Functional significance of bone density measurements in children with osteogenesis imperfecta. J Bone Joint Surg Am. 88(6):1324-1330, 2006.

Elkousy, H, Hammerman, SM, Edwards, TB, Warnock, KM, O’Connor, DP, Ambrose, C, Meyers, D, Gartsman, GM. The arthroscopic square knot: A biomechanical comparison with open and arthroscopic knots. Arthroscopy 22(7):736-741, 2006.

Clyburn T, Weitz-Marshall A, Ambrose C, Ursua V. Outcomes of patellofemoral replacement in total knee arthroplasty using meticulous techniques. Orthopedics 30(2):111-115, 2007.

Budoff JE, Meyers DM, and Ambrose CG. The Comparative Stability of Screw Versus Plate Versus Screw and Plate Coronoid Fixation. J Hand Surg, 36(2):238-245, 2011.

Mika J, Clanton TO, Pretzel D, Schneider G, Ambrose CG, Kinne RW. Surgical Preparation for Articular Cartilage Regeneration without Penetration of the Subchondral Bone Plate: In Vitro and In Vivo Studies in Human & Sheep. Am J Sports Med, 39(3):624-631, 2011.

Banks KE, Ambrose CG, Wheeless JS, Tissue CM, and Sen M. An Alternative Patellar Fracture Fixation: A Biomechanical Study. J Ortho Trauma, in press.

Jarvis H, Clanton T, Lewis E, Ambrose C, and Matheny L. Quantitative Analysis of Torsional Stiffness in Supplemental One-Third Tubular Plate Fixation in the Management of Isolated Syndesmosis Injuries – A Biomechanical Study. Foot and Ankle Int, in press.

Book Chapters

Ambrose, CG, Sharif, A, Diller, KR, and Hayes, LJ. A Numerical Design Methodology for a VLSI Cryostage, in Computational Methods in Bioengineering, Spilker, RL and Simon, BR, editors, 1988.

Katz, JL, Ambrose, CG, McMillin, CR, and Spencer, P. Orthopedic Biomaterials, in Encyclopedia of Biomaterials and Biomedical Engineering, Wnek, GE and Bowlin, GL, editors, 2004.

Ambrose CG and Hogan H. Ex Vivo Testing of Orthopedic Implants, in Orthopedic Implants: Applications, Complications, and Management, Lindsey, RW and Gugala, Z, editors, in press.