Biography

Dr. Johnny Huard is a Professor in the Department of Orthopedic Surgery at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth). Dr. Huard joins UT from the University of Pittsburgh, where he was an endowed professor and Vice Chair for the Department of Orthopedic Surgery and Musculoskeletal Cellular Therapeutics. He also served as the Director of the Stem Cell Research Center for University of Pittsburgh School of Medicine.

Dr. Huard completed his Ph.D. in Neurobiology at Laval University in Quebec before earning two post-doctoral degrees in Gene Therapy, the first from McGill University in Quebec, and the second from the University of Pittsburgh in Pittsburgh, Pennsylvania.

Dr. Huard possesses extensive knowledge in the areas of gene therapy, tissue engineering & regenerative medicine applications based on the use of muscle-derived stem cells (MDSCs). His primary areas of interest are in basic stem cell biology and their translation to clinic to aid in the healing and regeneration of a variety of tissues. His team has received national and international recognition, and the technologies that they have developed have been licensed to industry. Together, Dr. Huard and his team have published over 300 peer reviewed papers, 82 book chapters, and have had 757 abstracts accepted for presentation at national and international conferences.

Dr. Huard’s research has received over 80 honors and awards either locally or at national and international meetings. His research was featured on the cover of Stem Cells, Journal of Orthopedic Research, and Molecular Therapy including several from the American Orthopedic Society for Sports Medicine, the Orthopedic Research Society, and the American Association of Orthopedic Surgeons. He is active member of several professional and scientific societies including the American College of Sports Medicine, International Cartilage Repair Society, American Society for Biochemistry and Molecular Biology, and the American Association for the Advancement of Science.

 

Education

Undergraduate Degree
Gaspesie College, Gaspe, Canada
Undergraduate Degree
Rimouski University U.Q.A.R., Rimouski, Canada
Masters Degree
Neurobiology, Laval University, Quebec, Canada
Doctoral Degree
Neurobiology, Laval University, Quebec, Canada
Postdoctoral Fellowship
Gene Therapy, McGill University, Montreal, Canada
Postdoctoral Fellowship
Gene Therapy, University of Pittsburgh, Pittsburgh, Pennsylvania

Publications

Publication Information

Huard J, Verreault S, Roy R, Tremblay M, Tremblay JP. High efficiency of muscle regeneration after human myoblast clone transplantation in SCID mice. J Clin Invest 1994 Feb; 93(2):586-99.

Qu Z, Balkir L, van Deutekom JC, Robbins PD, Pruchnic R, Huard J. Development of approaches to improve cell survival in myoblast transfer therapy. J Cell Biol 1998 Sep 7; 142(5):1257-67.

Lee JY, Qu-Petersen Z, Cao B, Kimura S, Jankowski R, Cummins J, Usas A, Gates C, Robbins PD, Wernig A, Huard J. Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol 2000 Sep 4; 150(5):1085-100, PMID: 10973997

Peng H, Wright V, Usas A, Gearhart B, Shen HC, Cummins J, Huard J. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 2002 Sep; 110(6):751-9. PMID: 12235106

Qu-Petersen Z, Deasy BM, Jankowski R, Ikezawa M, Cummins J, Pruchnic R, Cao B, Mytinger J, Gates C, Wernig A, Huard J. Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. J Cell Biol 2002 May; 157(5):851-64. PMID: 12021255

Cao B, Zheng B, Jankowski RJ, Kimura S, Ikezawa M, Deasy B, Cummins J, Epperly M, Qu-Petersen Z, Huard J. Muscle stem cells differentiate into hematopoietic lineages but retain myogenic potential. Nat Cell Biol 2003 Jul; 5(7):640-6. PMID: 15872085

Zheng B, Cao B, Crisan M, Sun B, Li G, Logar A, Yap S, Pollett, JB, Drowley L, Cassino T, Gharaibeh B, Deasy B, Huard J, Péault B. Prospective identification of myogenic endothelial cells in human skeletal muscle. Nat Biotech 2007 Sep; 25(9):1025-34. J. Huard corresponding author. PMID: 17767154

Payne TR, Oshima H, Okada M, Momoi N, Tobita K, Keller B, Peng H, Huard J. A relationship between VEGF, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts. J. Am. Coll. Cardiology (JACC) 2007 Oct 23; 50(17) 1677-1684. Editorialized in JACC 2007 Oct 23; 50(17) 1685-1687. PMID: 17950150

Deasy B, Lu A, Tebbets J, Feduska J, Schugar R, Pollett J, Sun B, Urish K, Gharaibeh B, Cao B, Rubin R, Huard J. A role for cell sex in stem cell mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency. J Cell Biol 2007 Apr 9;177(1):73-86 PMID: 17420291

Gharaibeh B, Lu A, Tebbets J, Zheng B, Feduska J, Crisan M, Péault B, Cummins J, Huard J. Isolation of slowly adhering cells containing stem cells from murine skeletal muscle by the preplate technique. Nature Protocol 2008; 3(9); 1501-1509, PMID: 18772878

Crisan M, Park, TS Casteilla, L, Sun B, Zheng B, Yap S, Norotte C, Corselli M, Traas J, Deasy B, Andriolo G, Bühring HJ, Lazzari L, Giacobino JP, Huard J, Péault B. Perivascular origin of mesenchymal stem cells in multiple human tissues. Cell Stem Cell, 2008 Sep 11;3(3):301-13. PMID: 18786417

Okada M, Payne T, Zheng B, Oshima H, Momoi N, Tobita K, Keller B, Phillippi J, Péault B, Huard J. Myogenic endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infracted myocardium. J. Am. Coll. Cardiology (JACC), 2008 Dec; 52(23): 1869-1880. PMID: 19038685

Tilstra J, Robinson A, Wang J, Gregg S, Clauson C, Reay D, Nasto L, St Croix C, Usas A, Vo N, Huard J, Clemens P, Stolz D, Guttridge D, Watkins S, Garinis G, Wang Y, Niedernhofer L, Robbins P. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012 Jun 18.

Lavasani M, Robinson A, Lu A, Song M, Feduska J, Ahani B, Tilstra J, Feldman C, Robbins P, Niedernhofer L, Huard J. Muscle-derived stem cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun 2012 Jan; 3:608. PMID: 22215083

Lavasani M, Thompson SD, Pollett JB, Usas A, Lu A, Stolz DB, Clark KA, Sun B, Péault B, Huard J. “Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration.” J Clin Invest. 2014 Mar 18. PMID: 24642464

Fox IJ, Daley GQ, Goldman SA, Huard J, Kamp TJ, Trucco M “Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease”. Science. 2014 Aug 22;345(6199): 1247391. doi: 10.1126/science.1247391.

Evans C and Huard J. Gene therapy approaches to regenerating the musculoskeletal system. Nature Reviews Rheumatology 2014 (In Press).

Additional Information

Young Investigator Travel Grant, American Society for Bone and Mineral Research – September 2014
Li H; Lu A; Oyster N; Huard J. “Inhibition NF-κB Signaling Pathway by Partial Ablation of the P65 Subunit Leads to Improved Bone Quality without Interfering with Bone Healing” ASBMR annual meeting, September 12-15, 2014. Houston, TX.

ASBMR Rare Bone Disease Workshop Young Investigator Award – September 2014
Li H; Lu A; Tang Y; Wang B; Huard J. “Dystrophic Systemic Milieu Plays an Important Role in the Muscle and Bone Abnormalities in Duchenne Muscular Dystrophy” ASBMR annual meeting, September 12-15, 2014. Houston, TX.

Young Investigator Travel Grant, American Society for Bone and Mineral Research – September 2014
Xueqin Gao “Cyclooxygenase 2 deficiency impaired the bone regeneration capacity of muscle derived stem cells via cell autonomous and non-autonomous mechanisms.” ASBMR meeting, September 12-15, Houston, TX.

Nomination to serve on ORS board – June 2014

Meritorious Travel Award, American Society of Gene and Cell Therapy – May 2014 Xueqin Gao, ASGT Annual Meeting, Washington, DC, May 21 – 24, 2014.

Meritorious Travel Award, American Society of Gene and Cell Therapy – May 2014 William Chen, ASGT Annual Meeting, Washington, DC, May 21 – 24, 2014.

Travel Award – April 2014
William Chen.The 6th Pan Pacific Symposium on Stem Cells and Cancer Research, April 12-14, 2014, Taichung, Taiwan.

Oral Presentation Award – April 2014
William Chen, “Human Heart Pericytes Resident Multi-Lineage Precursor Cells Exhibiting Cardiac Specificty”, The 6th Pan Pacific Symposium on Stem Cells and Cancer Research, April 12-14, 2014, Taichung, Taiwan.

Travel Award – May 2014
Mu X, Gao, J, Wang Y, Weiss K, Huard J. “Mimicking the stem cell niche in diseased muscle by Notch activation” ASGCT 17th Annual Meeting, May 21-24 in Washington, DC, USA.

Electrode Store Award – February 2014
Kunj Patel, Association of Academic Physiatrists Annual Conference. “Immediate Massage Stimulates Muscle Regeneration, Angiogenesis, and Decreases Fibrosis after Muscle Injury” February 25-March 1, 2014.

Front Cover of Stem Cells (Volume 31, Number 2) – February 2013
Chen C, Okada M, Proto J, Gao X, Sekiya N, Beckman S, Corselli M, Crisan M, Saparov A, Tobita K, Péault B, Huard J .“Human Pericytes for Ischemic Heart Repair”
Front Cover of Journal of Orthopedic Research (Volume 31, Number 3) – March 2013
Isaac C, Wright A, Usas A, Li H, Tang Y, Mu X, Greco N, Dong Q, Vo N, Kang J, Wang B, Huard J. “Dystrophin and utrophin “double knockout” dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities”. J. Orth. Res. 2012 Oct 23. [Epub ahead of print]

Front Cover of Molecular Therapy (Volume 31, Number 3) – March 2013
Sekiya N, Tobita K, Beckman S, Okada M, Gharaibeh B, Sawa Y, Kormos RL, Huard J. “Muscle-derived Stem Cell Sheets Support Pump Function and Prevent Cardiac Arrhythmias in a Model of Chronic Myocardial Infarction”.
Order of Merit (OREF) – March 2013
Huard, J. 2013 AAOS Annual Meeting in Chicago; March 19-23, 2013; Chicago, IL.

Travel Award, American Society for Investigative Pathology – April 2013
Sohn J, Tang Y, Lu A, Wang B, and Huard J. “Proliferation and Differentiation Potentials of Adipose-Derived Stem Cells Isolated from Dystrophin and Utrophin Double Knockout mice.” Experimental Biology; April 20-24, 2013; Boston, MA.

Travel Award – April 2013
William Chen. The 6th Pan Pacific Symposium on Stem Cells and Cancer Research, April 13-15, 2013, Hsinchu, Taiwan.

Residents’ Day Award – April 2013
Nick Greco, Resident in the SCRC. Resident Research Day. University of Pittsburgh, April 30, 2013, Pittsburgh, PA.

First Place Pathology Retreat at the University of Pittsburgh – May 2013
Jonathan Proto, “Hepatocyte Growth Factor contributes to the beneficial effect of NF-kB blockade in a murine model of muscular dystrophy.” May 22, 2013. Pittsburgh, PA

Young Investigator Travel Award – October 2013
Hongshuai Li, “Evaluation of muscle derived stem cells combined with a sustained release of BMP2 coacervate for bone regeneration”. ASBMR Muscle Symposium. New Investigator Research Award (NIRA) – February 2012
Gao X, Usas A, Lu A, Tang Y, Poddar M, Tebbets JC, Huard M, Cummins JH, Huard J. “Role of donor and host cyclooxygenase-2 in muscle derived stem cell mediated bone healing in critical sized calvarial defect model.” 2012 ORS Annual Meeting; February 4-7, 2012; San Francisco, CA. Highlighted in International Chinese Hard Tissue Society Newsletter.
AFIRM Career Enrichment and Travel Support – February 2012
Gao X, Usas A, Lu A, Tang Y, Poddar M, Tebbets JC, Huard M, Cummins JH, Huard J. “Role of donor and host cyclooxygenase-2 in muscle derived stem cell mediated bone healing in critical sized calvarial defect model.”

Finalist for the AAA Langman Graduate Student Platform Presentation Award – April 2012
Sohn J, Kozemchak A, Oyster N, Thompson S, Tang Y, Lu A, Gharaibeh B, Wang B, Huard J. “Abnormal Proliferation and Defective Multilineage differentiation Potential of Adipose-Derived Stem Cells Isolated from Dystrophin and Utrophin Knockout Mice”. AAA’s Annual Meeting at Experimental Biology; April 21-25, 2012; San Diego, CA.

Finalist, Graduate Student Poster Presentation – April 2012
Proto J, Lu A, Robbins P, Niedernhofer L, Wang B, Huard J. “Strategies for the Rejuvenation of Aged Muscle Stem Cells”. American Anatomists Association Annual Meeting; San Diego, CA; April 21-25, 2012

Travel Award, American Society for Investigative Pathology – April 2012
Proto J, Lu A, Imbrogno K, Tang Y, Robbins P, Wang B, Huard J. “Suppression of Skeletal Muscle Inflammation by Muscle Stem Cells”. American Society of Investigative Pathology; San Diego, CA; April 21-25. 2012.

Travel Award recipient, American Association of Anatomists – April 2012
Beckman S, Mlakar L, Tang Y, Wang B, Huard J. “The Role of Vascular Endothelial Growth Factor in Mechanically Stimulated Muscle Derived Stem Cell Repair.” Experimental Biology; San Diego, CA; April 21-25 2012.

ICRS Cum Laude Certificate – May 2012
Li H, Poddar M, Usas A, Huard J. “Ex-vivo gene therapy-induced cartilage regeneration: comparison of different subpopulations of primary muscle-derived cells.” ICRS; Montreal, Canada; May 12-14, 2012.

New Investigator Research Award (NIRA) – January 2011
Yang Q, Tang Y, Lu A, Chen A, Guo F, Fu F, Huard J, Wang B. “AAV- based RNA silencing ameliorates muscle pathologies in young mdx mice by blocking the NF-κB pathway”. 2011 ORS Annual Meeting; January 13-16, 2011; Long Beach, CA.

New Investigator Recognition Award Finalist – January 2011
Gao X; Usas A; Lu A; Tebbets JC;Tang Y; Li H; Huard J: “MDSCs promote bone healing by contributing directly to bone regeneration and by inducing early and enhanced inflammation and angiogenesis”. ORS 2011 Annual Meeting, Jan13-16, Long Beach, CA

Armed Forces Institute of Regenerative Medicine (AFIRM) WFPC Career Enrichment & Travel Support – December 2011
Mu XD, Takayama K, Tang Y, Wang B, Weiss K, Huard J. “Role of Notch signaling in stem cell behavior in dystrophic muscle.” 51th Annual meeting of American Society for Cell Biology (ASCB), December 3-7 2011; Denver CO.

American Society of Cell Biology (ASCB) Postdoc travel grant – December 2011
Mu XD, Takayama K, Tang Y, Wang B, Weiss K, Huard J. “Role of Notch signaling in stem cell behavior in dystrophic muscle”. 51th Annual meeting of American Society for Cell Biology (ASCB), December 3-7 2011; Denver CO.

Travel Award – June 2011
Chen C, Proto J, Gao X, Okada M, Corselli M, Crisan M, Tobita K, Péault B, Huard J. “The Paracrine Mechanism of Anti-fibrotic and Anti- inflammatory Effects of Human Perivascular Stem Cells”, 9th Annual Meeting of International Society for Stem Cell Research; Toronto, Canada; June 15-18, 2011.

Best Poster Presentation – July 2011
Gao X, Usas A. Lu A, Proto J, Tebbets J, Li H, Cummins J, Huard J. “Muscle derived stem cells transduced with BMP4 interact with host cells to promote bone healing in critical sized skull defect.” University of Pittsburgh Postdoctoral Association 2011 Postdoctoral Data & Dine Symposium; Pittsburgh, PA

Best Oral Presentation in the Compartment Syndrome Category – Jan. 2010
Uehara K, Kobayashi T, Ota S, Sun B, Tobita K, Ambrosio F, Gharaibeh B, Fu FH, Huard J. “Angiotensin Receptor Blocker Improves Skeletal Muscle Function Recovery in a Dose Dependent Manner.” AFIRM All Hands Meeting; St. Pete, FL; January 11-14, 2010.

Nominee 11th Annual Royan Research Award, Royan International Congress – 2010
Dr. Huard and Dr. Kennith Urish were selected for this award for their paper “Antioxidant Levels Represent a Major Determinant in the Regenerative Capacity of Muscle Stem Cells” published in Molecular Biology of the Cell Journal. This is an annual prize for the best five researches in reproductive biomedicine and stem cell research.

Second Place Poster Award, Cellular Therapies Category – March 2010
Chen CW, Okada M, Tobita K, Peault B, Huard J. “Regenerative Medicine for Myocardial Infarction Using Perivascular Stem Cells”. McGowan Institute for Regenerative Medicine 2010 Scientific Retreat; March 7-10, 2010; Pittsburgh, PA.

New Investigator Travel Award – May 2010
Lavasani M, Robinson A, Lu A, Tilstra J, Feduska J, Robbins P, Niedernhofer L, Huard, J. “Mouse muscle-derived stem cells in a murine model of accelerated aging”. The Ottawa Conference on New Directions in Biology and Disease of Skeletal Muscle; May 5-8, 2010; Ottawa, Canada.

New Investigator Research Award (NIRA) Finalist – October 2010
Mifune Y, Matsumoto T, Nishimori M, Ota S, Usas A, Kuroda R, Kurosaka M, Fu F, Huard J. “The therapeutic potential of ACL-derived CD34 positive cells for the ACL Reconstruction.” 7th Combined Meeting of the Orthopedic Research Societies; October 16-20, 2010; Kyoto, Japan.

ATVB Young Investigator Travel Award – November 2010
Chen CW, Corselli M, Okada M, Crisan M, Tobita K, Péault B, Huard J. “The anti-fibrotic and anti-inflammatory potentials of purified human muscle derived perivascular cells for the treatment of myocardial infarction.” American Heart Association Scientific Sessions 2010; Chicago, IL

Young Investigator Travel Award – May 2010
Chen CW, Corselli M, Sun B, Péault B, Huard J. “Multi-lineage mesodermal progenitors within human myocardium.” XXth World Congress of the international Society for Heart Research; Kyoto, Japan

Second Place Winner – March 2010
Chen CW, Okada M, Tobita K, Péault B, Huard J. Regenerative medicine for myocardial infarction using perivascular stem cells. McGowan Institute for Regenerative Medicine Scientific Retreat, Poster Contest: Cellular Therapies; Pittsburgh, PA