Seminar/Journal Club Series open to all interested individuals

UTHealth Graduate School Course GS21 1041   Course Director/Coordinator: Steven J. Norris, Ph.D.

Translational research represents the dynamic interface between basic research and medical practice, in which each field provides vital information to the other. The purpose of this course is to introduce students to the concepts of clinical and translational research, and its application to both improved health care and enhanced understanding of biologic processes. The course will alternate between seminar and journal club formats.  Every other week, experts in a variety of fields (such as cancer biology, microbiology/infectious diseases, cardiac surgery, gene therapy, drug development, and radiology/radiation physics) will present their views of the translational research process, followed by group discussion.  During the subsequent week, the students will lead discussion of two articles in the same research area in a round-table format.  All students, faculty, fellows, and staff are welcome to attend.

Blue Book Credit for Medical Students
UTHealth medical students who participate in 8 or more sessions (seminars or journal clubs) for the Topics in Clinical and Translational Sciences Course are eligible to receive blue book credit. (Blue Book information is incorporated into the Dean’s letter of recommendation for residency applications.) In order to receive credit for each session, you must sign the logbook kept in the back of the lecture hall and attend the entire lecture. (Early departure as needed for medical school classes is permitted.) If you fulfill these criteria, a letter will be forwarded to the Dean’s office for inclusion in the Blue Book.


All class sessions will be in the GSBS Small Classroom (Basic Science Research Building (BSR) S3.8367) unless otherwise noted.  Map

Lecture Calendar
Wednesday, August 27, 2014 from 4-5 pm in the Onstead Auditorium (BSR S3.8012)

John B. Holcomb, M.D. – “Translational Injury Research”


Wednesday, September 3, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Journal club on Translational Injury Research/Evidence-Based Medicine (with Charles E. Wade, Ph.D., Professor, Department of Surgery, McGovern Medical School)

Paper 1: Endpoints in clinical trials of fluid resuscitation of patients with traumatic injuries. Wade CE, Holcomb JB. Transfusion. 2005 Jul;45(1 Suppl):4S-8S. Review. PMID: 15989685 Link

Paper 2: Comprehensive analysis of mortality among patients undergoing TAVR: results of the PARTNER trial. Svensson LG, Blackstone EH, Rajeswaran J, Brozzi N, Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Tuzcu EM, Webb JG, Kapadia S, Fontana GP, Makkar RR, Brown DL, Block PC, Guyton RA, Thourani VH, Pichard AD, Bavaria JE, Herrmann HC, Williams MR, Babaliaros V, Généreux P, Akin JJ; PARTNER Trial Investigators. J Am Coll Cardiol. 2014 Jul 15;64(2):158-68. doi: 10.1016/j.jacc.2013.08.1666.  PMID: 25011720 Link


Wednesday, September 10, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Elizabeth A. Mittendorf, M.D., Ph.D. – Breast Cancer Immunotherapy


Wednesday, September 17, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Journal club – Breast Cancer Immunotherapy, Elizabeth A. Mittendorf, M.D., Ph.D.

Paper 1: Booster vaccinations against cancer are critical in prophylactic but detrimental in therapeutic settings.  Ricupito A, Grioni M, Calcinotto A, Hess Michelini R, Longhi R, Mondino A, Bellone M.  Cancer Res. 2013 Jun 15;73(12):3545-54. doi: 10.1158/0008-5472.CAN-12-2449. Epub 2013 Mar 28.  PMID: 23539449 Article Discussion leader: Arianexys Aquino

Paper 2: Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion.  Hailemichael Y, Dai Z, Jaffarzad N, Ye Y, Medina MA, Huang XF, Dorta-Estremera SM, Greeley NR, Nitti G, Peng W, Liu C, Lou Y, Wang Z, Ma W, Rabinovich B, Sowell RT, Schluns KS, Davis RE, Hwu P, Overwijk WW.  Nat Med. 2013 Apr;19(4):465-72.  Article  Discussion leader: Collene Jeter


Wednesday, September 24, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Peter J. Hotez, M.D., Ph.D. – Neglected Tropical Diseases and the Anti-Poverty Vaccines


Wednesday, October 1, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Journal club on Neglected Tropical Diseases

Suggested articles:

“Vaccine diplomacy”: historical perspectives and future directions. Hotez PJ. PLoS Negl Trop Dis. 2014 Jun 26;8(6):e2808. doi: 10.1371/journal.pntd.0002808. eCollection 2014 Jun. No abstract available. PMID: 24968231 [PubMed – in process] Free PMC Article Related citations

NTDs V.2.0: “blue marble health”–neglected tropical disease control and elimination in a shifting health policy landscape. Hotez PJ. PLoS Negl Trop Dis. 2013 Nov 21;7(11):e2570. doi: 10.1371/journal.pntd.0002570. eCollection 2013 Nov. PMID: 24278496 Free PMC Article

The Human Hookworm Vaccine. Hotez PJ, Diemert D, Bacon KM, Beaumier C, Bethony JM, Bottazzi ME, Brooker S, Couto AR, Freire Mda S, Homma A, Lee BY, Loukas A, Loblack M, Morel CM, Oliveira RC, Russell PK. Vaccine. 2013 Apr 18;31 Suppl 2:B227-32. doi: 10.1016/j.vaccine.2012.11.034. Review. PMID: 23598487  Free PMC Article


Wednesday, October 8, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Robert C. Bast, Jr., M.D. (GSBS Link) – “Translational Approaches to the Management of Ovarian Cancer”


Wednesday, October 15, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Journal club on Translational Approaches to the Management of Ovarian Cancer (Presented by Shelley Herbrich, with Dr. Robert Bast)

Primary Article: Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial.  Rustin GJ, van der Burg ME, Griffin CL, Guthrie D, Lamont A, Jayson GC, Kristensen G, Mediola C, Coens C, Qian W, Parmar MK, Swart AM; MRC OV05; EORTC 55955 investigators.  Lancet. 2010 Oct 2;376(9747):1155-63.  Link

Additional Articles: Mathematical model identifies blood biomarker-based early cancer detection strategies and limitations. Hori SS, Gambhir SS.  Sci Transl Med. 2011 Nov 16;3(109):109ra116.  Link

The preclinical natural history of serous ovarian cancer: defining the target for early detection.  Brown PO, Palmer C.  PLoS Med. 2009 Jul;6(7):e1000114.  Link


Wednesday, October 22, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Bruce D. Butler, Ph.D.  – Technology Transfer in an Academic Setting


Wednesday, October 29, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Steven J. Norris, Ph.D. (GSBS Link) – Lyme disease serodiagnostics as an example of translational research and technology transfer


Wednesday, November 5, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Laurence J. N. Cooper, M.D., Ph.D. – “Translating Immunology into Immunotherapy”


Wednesday, November 12, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Journal club on Translating Immunology into Immunotherapy

Article 1: Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.  Tran, E. et al.  Science 344, 641 (2014); DOI: 10.1126/science.1251102.

Article 2: Chimeric antigen receptor T cells for sustained remissions in leukemia.  Maude, S. L. et al. N. Engl. J. Med. 371;16 (2014).


Wednesday, November 19, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Yang Xia, Ph.D. (GSBS link) – “Translational studies reveal novel mechanisms to predict and treat preeclampsia”


Wednesday, November 26, 2014  – no meeting (Thanksgiving)


Wednesday, December 3, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Journal club on Translational studies reveal novel mechanisms to predict and treat preeclampsia

Article 1: Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice.  Zhou CC et al. Nature Medicine 14:855-862, 2008.

Article 2: The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia.  Irani RA et al. J. Exp. Med. 206:2809-2822, 2009.


Wednesday, December 10, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Jeffrey N. Myers, M.D., Ph.D. (GSBS Link) – “Precision Head and Neck Cancer Treatment”


Wednesday, December 17, 2014 from 4-5 pm in GSBS Small Classroom (BSR S3.8367)

Journal club on Mutational Analysis of Squamous Cell Carcinoma

Article 1 (for discussion): Mutational landscape of aggressive cutaneous squamous cell carcinoma.  Pickering CR et al., Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-14-1768, OnlineFirst October 10, 2014.

Article 2: Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers.  Pickering CR et al., Clin. Cancer Res. doi:10.1158/1078-0432.CCR-14-0565, 2014.

Article 3: Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.  Zhou et al., Molecular Cell 54, 1–15, June 19, 2014.