Professor , Department of Pathology and Laboratory Medicine
Areas of Interests
- Research Interest
- My laboratory investigates the immunological mechanisms of vaccines and adjuvants, focusing on tuberculosis, which is the leading cause of death due to infections in mankind.
My laboratory investigates the immunological mechanisms of vaccines and adjuvants, focusing on tuberculosis, which is the leading cause of death due to infections in mankind.
The BCG vaccine and Mycobacterium tuberculosis organisms are processed by the antigen presenting cells like macrophages and dendritic cells (APCs), and peptides presented to CD4 and CD8 T cells through MHC-II and MHC-I pathways to trigger Th1 immunity. However, both the vaccine and pathogen sequester within APCs and evade immune evasion.
The major emphasis of our laboratory is therefore to increase the antigen processing mechanisms, improving the efficacy of BCG vaccine and related adjuvants. We have genetically modified BCG vaccine to render it an autophagic vaccine (Nature Medicine 2009) and currently analyzing intracellular TLR and NLR signaling mechanisms to activate APCs. A tutorial in my laboratory will therefore give an insight into the intracellular mechanism of APCs, especially autophagy-dependent antigen processing mechanisms and help to understand the molecular basis for host-defense. Another thrust area is the induction of long term memory to infections through enhancing APC-T cell cross talk.
We pioneered the use of rapamycin to induce autophagy to boost vaccine efficacy and also increase immune memory mediated by CD4 and CD8 T cells. We are using mouse models to investigate the immunological basis of vaccine and adjuvant driven long-term immunity mediated by CD8 and CD4 T cells against tuberculosis. Since BCG can be engineered to deliver heterologous antigens, we are also developing a global vaccine platform using the live attenuated BCG vaccine.
A rotation in my laboratory will therefor provide cutting-edge solutions to improve vaccines and adjuvants and strengthening host immunity.
Jagannath Laboratory- STUDENT AWARDS
- 2011 Molecular Basis of Infectious Disease Retreat 3rd prize poster-Pearl Bakhru
- 2010-2011 Molecular Basis of Infectious Disease Institutional Training Grant stipend-Pearl Bakhru
- 2009 Robert W. and Pearl Wallis Knox Charitable Foundation Scholarship-Chris Singh
- 2007 Molecular Basis of Infectious Disease Institutional Training Grant stipend-Chris Singh
- 2006 The Changing Landscape of Vaccine Development Symposium Poster Award-C.Singh
- 2006 Annual Graduate Student Award in Science and Engineering for the Rice/TMC Chapter of Sigma Xi‐Best thesis
- 2006 Academy of Medicine, Engineering and Science of Texas Poster Award for Vaccine Category
- 2006 Bugs, Drugs and Vaccines: Securing Our Future Symposium Tanox, Inc. Travel Award and Platform Presentation
- 2006 AAI FASEB‐MARC Travel Award
- 2005 L.D. Mehta Achievement Award
- 2005 McGovern Award Pre‐Candidacy
- 2005 McLaughlin Travel Award, Galveston National Meeting on Bioterrorism
- 2006 Minority mentee-Faculty Mentor award-sponsored by the AAI-FASEB-NIH
- 2009-Mario Toppo Outstanding scientist award