Peking University Health Science Center, Beijing China 1995-2000
Cornell Medical College, New York at Buffalo, Buffalo, New York, NY 2001-2006

Areas of Interests

Clinical Interests

Surigcal Pathology and Cytopathology


Publication Information

  1. Zhu, H.; Yin, S.; and Shuman, S., (2004) Characterization of polynucleotide kinase/phosphatase enzymes from Mycobacteriophages omega and Cjw1 and vibriophage KVP40. Biol. Chem. 279(25), 26358-26369
  2. Zhu, H., and Shuman, S. (2005) A primer-dependent polymerase function of Pseudomonas aeruginosa ATP-dependent DNA ligase (LigD). Biol. Chem. 280(1), 418-427.
  3. Zhu, H. and Shuman, S. (2005) Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA). Biol. Chem. 280(13), 12137-12144.
  4. Gong, C.; Bongiorno, P.; Martins, A.; Stephanou, N.C.; Zhu, H.; Shuman, S.; and Glickman, M.S. (2005). Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nature Struct. Mol. Biol. 12(4), 304-312.
  5. Zhu, H. and Shuman, S. (2005). Novel 3′-ribonuclease and 3′-phosphatase activities of the bacterial non-homologous end-joining protein, DNA ligase D. Biol. Chem. 280(28), 25973-25981.
  6. Zhu, H.; Wang, L.K.; and Shuman S. (2005). Essential constituents of the 3′-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme. Biol. Chem. 280(40), 33707-33715.
  7. Zhu, H.; Nandakumar, J.; Aniukwu, J.; Wang, L.K.; Glickman, M.S.; Lima, C.D.; and Shuman, S. (2006) Atomic structure and NHEJ function of the polymerase component of bacterial DNA ligase D. Nat. Acad. Sci. USA 103(6):1711-1716.
  8. Zhu, H. and Shuman S. (2006) Substrate specificity and structure-function analysis of the 3’-phosphoesterase component of the bacterial NHEJ protein, DNA ligase D. Biol. Chem. 281 (20): 13873-13881.
  9. Zhu, H. and Shuman S. (2007) Characterization of Agrobacterium tumefaciens Ligase Cs and Ligase Ds. Nucleic Acid Research, 35(11):3631-45.
  10. Zhu, H.; Smith P.; Wang, LK.; and Shuman S. (2007) Structure-function analysis of the 3’ phosphatase component of T4 polynucleotide kinase/phosphatase. Virology, 366(1):126-136.
  11. Zhu, H. and Shuman, S. (2008). Bacterial NHEJ ligases preferentially seal breaks with a 3′-OH monoribonucleotide. Biol. Chem., 283 (13): 8331-8339.
  12. Wang, L.K.; Zhu, H.; and Shuman, S. (2009) Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli DNA ligase (LigA). Biol. Chem. 284(13):8486-94.
  13. Zhu, H. and Shuman, S. (2009) Gap-filling activities of Pseudomonas DNA ligase D (LigD) polymerase and functional interactions of LigD with the DNA-end binding Ku protein. J Biol Chem. 285(7):4815-25.
  14. Smith, P.; Nair, PA.; Das, U.; Zhu, H.; and Shuman, S. (2011) Structures and activities of archaeal members of LigD 3’ phosphatase DNA repair enzyme superfamily. Nucleic Acids Res. 39(8):3310-20.
  15. Zhu, H.; Bhattarai, H.; Yan, H.; Shuman, S.; and Glickman, M. (2012) Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D. Biochemistry. 51(51):1047-58.
  16. Li, Z; Zhu, H; Shi, H; Xie, H; Goldblum, J; Thota P; Liu, X. (2015) Lymphovascular invasion and nodal metastasis in intramucosal adenocarcinoma of the esophagus and esophagogastric junction. Journal of Digestive Diseases. 16(4): 197-04.
  17. Zhu, H.; Booth, CN.; Reynolds, JP. (2015) Clinical presentations and cytopathologic features of malignant pericardial cytology: a single institution analysis spanning a 29-year period. Journal of the American Society of Cytopathology. 2015 4(4): 203-9.
  18. Zhu, H., McMeekin, EM., Sturgis, CD. (2015) Desmoplastic small round cell tumor, a “floating island” pattern in pleural fluid cytology: a case report and review of the Literature. Case Report in Pathology 2015: 676894.
  19. Zhu, H., Sun, J., Wei, S., Wang, D., and Brandwein, MS. (2016) Well-Differentiated Laryngeal/Hypopharyngeal Liposarcoma in the MDM2 Era Report of Three Cases and Literature Review. Head and Neck Pathology. In press.


  1. Sun, J., Burke, MS., Zhu, H., Loree TR., Brandwein MS. (2016) Conjunctival squamous cell carcinoma in an HIV+ woman: Association with high-risk human papillomavirus. Human Pathology: Case Reports. In press.


  1. He, J., Cai, Z., Zhu, H. (2016) Ducts of Luschka as a mimicker of well-differentiated adenocarcinoma of gallbladder: a case report and review of literature. Accepted for publication in North American Journal of Medicine and Science.

Additional Information


Texas Medical License #L5958, since 2003.

The American Board of Pathology, combined Anatomic and Clinical Pathology since 2001.

The American Board of Pathology, Subspecialty Certificate in Cytopathology, since 2002.


Three years private practice pathology at Northeast Medical Center, Humble, TX and North Cypress Medical Center, Cypress, TX.

Nine years laboratory research at University of California, San Francisco, CA and Henry Ford Hospital, Detroit, MI.


Pathologist, Buffalo General Hospital, Buffalo, NY 08/2015 – 08/2016

Pathologist, Erie County Medical Center, Buffalo, NY 08/2015 – 08/2016

Cytopathology Laboratory Director, Erie County Medical Center, Buffalo, NY 03/2016 – 08/2016


United States and Canadian College of Pathologists

College of American Pathologists

American Society for Clinical Pathologists

American Society of Cytopathology

Chinese American Pathologists Association


  1. Harvey E. Nussbaum Research Institute Small Grant Award, Saint Barnabas Health Care System, New Jersey, 2011-2012
  2. Ellen M. Cosgrove Research Award, Monmouth Medical Center, New Jersey, 2011 and 2012
  3. Research Competition Award, Association of Chinese American Physicians (ACAP) 2012 Annual Meeting

Conference Presentations:

  1. Zhu, H.; Khattab, R.; Martein, B., and Reynolds, J. Signet-ring cells in pleural effusions identified on Wright stains – a diagnostic pitfall. Poster presentation at ASC 2014 annual conference.
  2. Khattab, R.; Zhu, H.; and Reynolds, J. Cytohitologic correlation of benign bladder conditions with urine cytology: a retrospective slide review. Poster presentation at ASC 2014 annual conference.
  3. Zhu, H.; Booth, C.; and Reynolds, J. Pericardial cytopathology: a retrospective analysis of 944 cases spanning a 29-year period. Poster presentation at ASC 2013 annual meeting.
  4. Zhu, H. and Goyal, A. Metastatic squamous cell carcinoma in effusion cytology – an institutional study. Poster presentation at ASC 2013 annual meeting.
  5. Zhu, H.; Gmitro, S.; Imondi, G.; Reynolds, J. Atypical pleural effusions: A single institution experience over a 7 year period. Poster presentation at ASC 2013 annual meeting.
  6. Zhu, H., Li, Z., Xie, H., Rice, TW., Rybicki, LA., Goldblum, JR., and Liu, X. Etiology and histomorphology of esophagogastric junction intramucosal adenocarcinoma (IMC): in comparison to esophageal IMC. Poster presentation at USCAP 2013 annual meeting.
  7. Zhu, H.; Sy, GM.; Santos-Zabala, ML.; and Dardik, M. Hep Par-1 immunohistochemical staining of mitochondrion-rich oncocytic neoplasms. Poster presentation at CAP 2012 annual meeting.
  8. Zhu, H.; Soong, J.; Coblentz, M.; and Lara, J. Primary plasmacytoma of the gastrointestinal tract. Poster presention at ASCP 2011 annual meeting.
  9. Zhu, H.; Santos-Zabala, ML.; Kim, BK.; and Dardik, M. Metastatic endometrioid carcinoma in a lymph node with lymphangioleiomyomatosis. Poster presentation at CAP 2011 annual meeting.
  10. Zhu, H.; Pulinthanathu, R.; Butholarova, T.; and Ongcapin, E. Epidermoid cyst at rare locations: report of two cases and review of literature. Poster presentation at ASCP 2011 annual meeting.
  11. Zhu, H.; Nair PA.; Shuman, S.; and Ghosel, R. Structure/Function Correlations in P. aeruginosa DNA Ligase D. Poster presentation at annual Biophysical Society meeting, USA, 2009.
  12. Shuman, S.; Aniukwu, J.; Zhu, H.; and Glickman. M. Mechanism of Bacterial NHEJ. Presentation at 3rd Microbial Genome Maintenance Meeting, Norway, 2008