
Hui Zhu, MD
- Assistant Professor of Pathology-Clinical, Department of Pathology and Laboratory Medicine
Education
- MD
- Peking University Health Science Center, Beijing China 1995-2000
- PhD
- Cornell Medical College, New York at Buffalo, Buffalo, New York, NY 2001-2006
Areas of Interests
Clinical Interests
Surigcal Pathology and Cytopathology
Publications
Publication Information
- Zhu, H.; Yin, S.; and Shuman, S., (2004) Characterization of polynucleotide kinase/phosphatase enzymes from Mycobacteriophages omega and Cjw1 and vibriophage KVP40. Biol. Chem. 279(25), 26358-26369
- Zhu, H., and Shuman, S. (2005) A primer-dependent polymerase function of Pseudomonas aeruginosa ATP-dependent DNA ligase (LigD). Biol. Chem. 280(1), 418-427.
- Zhu, H. and Shuman, S. (2005) Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA). Biol. Chem. 280(13), 12137-12144.
- Gong, C.; Bongiorno, P.; Martins, A.; Stephanou, N.C.; Zhu, H.; Shuman, S.; and Glickman, M.S. (2005). Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nature Struct. Mol. Biol. 12(4), 304-312.
- Zhu, H. and Shuman, S. (2005). Novel 3′-ribonuclease and 3′-phosphatase activities of the bacterial non-homologous end-joining protein, DNA ligase D. Biol. Chem. 280(28), 25973-25981.
- Zhu, H.; Wang, L.K.; and Shuman S. (2005). Essential constituents of the 3′-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme. Biol. Chem. 280(40), 33707-33715.
- Zhu, H.; Nandakumar, J.; Aniukwu, J.; Wang, L.K.; Glickman, M.S.; Lima, C.D.; and Shuman, S. (2006) Atomic structure and NHEJ function of the polymerase component of bacterial DNA ligase D. Nat. Acad. Sci. USA 103(6):1711-1716.
- Zhu, H. and Shuman S. (2006) Substrate specificity and structure-function analysis of the 3’-phosphoesterase component of the bacterial NHEJ protein, DNA ligase D. Biol. Chem. 281 (20): 13873-13881.
- Zhu, H. and Shuman S. (2007) Characterization of Agrobacterium tumefaciens Ligase Cs and Ligase Ds. Nucleic Acid Research, 35(11):3631-45.
- Zhu, H.; Smith P.; Wang, LK.; and Shuman S. (2007) Structure-function analysis of the 3’ phosphatase component of T4 polynucleotide kinase/phosphatase. Virology, 366(1):126-136.
- Zhu, H. and Shuman, S. (2008). Bacterial NHEJ ligases preferentially seal breaks with a 3′-OH monoribonucleotide. Biol. Chem., 283 (13): 8331-8339.
- Wang, L.K.; Zhu, H.; and Shuman, S. (2009) Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli DNA ligase (LigA). Biol. Chem. 284(13):8486-94.
- Zhu, H. and Shuman, S. (2009) Gap-filling activities of Pseudomonas DNA ligase D (LigD) polymerase and functional interactions of LigD with the DNA-end binding Ku protein. J Biol Chem. 285(7):4815-25.
- Smith, P.; Nair, PA.; Das, U.; Zhu, H.; and Shuman, S. (2011) Structures and activities of archaeal members of LigD 3’ phosphatase DNA repair enzyme superfamily. Nucleic Acids Res. 39(8):3310-20.
- Zhu, H.; Bhattarai, H.; Yan, H.; Shuman, S.; and Glickman, M. (2012) Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D. Biochemistry. 51(51):1047-58.
- Li, Z; Zhu, H; Shi, H; Xie, H; Goldblum, J; Thota P; Liu, X. (2015) Lymphovascular invasion and nodal metastasis in intramucosal adenocarcinoma of the esophagus and esophagogastric junction. Journal of Digestive Diseases. 16(4): 197-04.
- Zhu, H.; Booth, CN.; Reynolds, JP. (2015) Clinical presentations and cytopathologic features of malignant pericardial cytology: a single institution analysis spanning a 29-year period. Journal of the American Society of Cytopathology. 2015 4(4): 203-9.
- Zhu, H., McMeekin, EM., Sturgis, CD. (2015) Desmoplastic small round cell tumor, a “floating island” pattern in pleural fluid cytology: a case report and review of the Literature. Case Report in Pathology 2015: 676894.
- Zhu, H., Sun, J., Wei, S., Wang, D., and Brandwein, MS. (2016) Well-Differentiated Laryngeal/Hypopharyngeal Liposarcoma in the MDM2 Era Report of Three Cases and Literature Review. Head and Neck Pathology. In press.
- Sun, J., Burke, MS., Zhu, H., Loree TR., Brandwein MS. (2016) Conjunctival squamous cell carcinoma in an HIV+ woman: Association with high-risk human papillomavirus. Human Pathology: Case Reports. In press.
- He, J., Cai, Z., Zhu, H. (2016) Ducts of Luschka as a mimicker of well-differentiated adenocarcinoma of gallbladder: a case report and review of literature. Accepted for publication in North American Journal of Medicine and Science.