Education

Fellowship
Transfusion Medicine, Baylor College of Medicine, 2012
Residency
Pathology, University of Texas health Science Center, 2011
M.D.
University of Miami Miller School of Medicine, 2007
B.S. with Honors
University of Florida, 2002

Areas of Interests

Clinical Interests

Blood Utilization in Cardiovascular Surgery, Heparin Induced Thrombocytopenia in Cardiovascular Surgical Patients, Integration of Laboratory Medicine into Clinical Practice


Research Interests

Coagulation, Hemotherapy, Indirect saving and impact on patient care

Research Information

Coagulation is impacted by patient and laboratory related factors. Recently, I have been engaged to a project to determine how specimen processing techniques impact coagulation results. Namely how the pneumatic tube system effects prothrombin time, partial thromboplastin time, fibrinogen, d-dimer.

Other areas of research interest include Hemotherapy.  Hemotherapy is a clinical service functions to mitigate the hemostatic risks of critically ill (advanced cardiovascular devices, surgical interventions, and inherited and acquired coagulopathies) in hospital patients. This service offers the following consultative service: preoperative bleeding risk assessment, intra-operative bleeding management, post-operative bleeding management, post-procedural anticoagulation management, anticoagulation management of high bleeding risk patients, anticoagulation management of thrombophilic patients, ECMO anticoagulation and transfusion management, and consultative services for patients with special transfusion needs.  As this is an evolving field in pathology, I am engaged in several projects to demonstrate the patient centered benefits and value of this service.

Publications

Publication Information

Abstracts
K Klein, A Cote, L Chen: Classical Hodgkins Lymphoma an Atypical Presentation. Texas Society of Pathologist Annual Meeting, Austin, TX, 2009.

K Klein, A Gullett, S Risin: Hemoglobin J variants: Challenges in Identification by Electrophoresis and High Performance Liquid Chromatography. American Society of Clinical Pathology Annual Meeting, Chicago, IL, 2009.

K Klein and N Tatevian: Case Report: unexplained Case of Intrauterine Fetal Demise Resolved. Texas Society of Pathologist Annual Meeting, San Antonio, TX, 2010.

K Klein, A Tholpady, L R Kidd, Y Bai: Benefit of Plasmapheresis in Waldenstrom Macroglobulinemia. American Association of Blood Banking Annual Meeting, Baltimore, MD, 2010.

S Chen, C Albarracin, H Wang, K Klein, Sahin A, H Wang: Downregulation of Hematopoietic Progenitor Kinase 1 Protein Level in Ductal Carincoma In Situ and invasive Ductal Carcinoma of the Breast. United States and Canadian Academy of Pathology Annual Meeting, Washington, DC, 2010.

AE Gullett, VG Prieto, A Lopez, K Klein, B Arun, I Bedrosian, E Resetkova, Y Wu, N Sneige, and CT Albarracin: Type of Mammary Paget Disease is associated with Disease Free Survival. United States and Canadian Academy of Pathology Annual Meeting, Washington, DC, 2010.

R Diaz, E P Soundar, S K Hartman, K L Klein, Z Dreyer, K Eldin, S R Hui, J Teruya: Effectiveness and Safety of Granulocyte Transfusions for the Treatment of Systemic Infections in Children with Neutropenia or Granulocyte Dysfunction. American Association of Blood Banking Annual Meeting, Boston, MA, 2012.

D Nguyen, K L Klein, V Kostousov, K Nguyen, J Teruya, S R Hui: Adobe Lightroom Computer Assisted Kleihauer-Betke Testing Can Be a Cost Effective and Superior Alternative to Traditional Manual Method. American Association of Blood Banking Annual Meeting, Boston, MA, 2012.

B Castillo, E G Nedelcu, A Wahed, Y Bai1, K L Klein, I Gregoric, M Patel, B Kar, P Loyalka, A Nguyen: Intraoperative Coagulation-Based Hemotherapy Protocol Decreases Reoperation due to Postoperative Bleeding Complications with Left Ventricular Assist Device Implantation. American Association of Blood Banking Annual Meeting, Denver, CO, 2013.

R S Huang, K J Welsh, E Jacobi, H Tint, Y Bai1, A Nguyen, E G Nedelcu, A Wahed, K L Klein:  Efficacy of Therapeutic Plasma Exchange in Heparin-induced Thrombocytopenia Patients Prior to Cardiac Surgery with Heparin. American Association of Blood Banking Annual Meeting, Philadelphia, PA, 2014.

B Chang, K L Klein, H Tint, M Ling, A Sieg, A Wahed, E G Nedelcu, A Nguyen, S Nathan, Y Bai:  Biopsy and Donor-Specific Antibody Trends Associated with Plasmapheresis for Antibody-Mediated Rejection in Heart Transplantation. American Association of Blood Banking Annual Meeting, Philadelphia, PA, 2014.

E Jacobi, K J Welsh, A Al-Ibraheemi, K L Klein, Y Bai, H Tint: Cold Agglutinin Disease Causing Limb Ischemia with Dramatic Response to Therapeutic Plasma Exchange: A Case Report. American Association of Blood Banking Annual Meeting, Philadelphia, PA, 2014.

E Salazar, K L Klein, H Tint, E G Nedelcu, Y Bai: Iron Deficiency Anemia in Chronic Therapeutic Plasma Exchange. American Association of Blood Banking Annual Meeting, Anaheim, CA, 2015.

Original Articles
A Dasgupta, K Klein, S Risin, J Actor: Rapid Detection of Oleander poisoning by Dimension Vista Digoxin Assay (Flex Reagent Cartridge). Journal of Clinical Laboratory Analysis. 25(2): 105-109, 2011.

K Shinil, L Kreiner, P Walker, K Klein, K Bajwa, E Robinson, S Millas, E Souchon, C Wray: Cytomegalovirus Enteritis Manifesting as Recurrent Bowel Obstruction and Jejunal Perforation in Patients with Acquired Immunodeficiency Syndrome: Rare Report of Survival and Review of the Literature. Surgical Infection. 13(2): 121-124, 2012.

K Klein, SK Hartman, J Teruya, SK Hui: Algorithmic Approach to Coagulation Testing. Disease-a-Month. 58(8): 431-439, 2012.

A Tholpady, J Monson, R Radovancevic, K Klein, A Bracey: Analysis of Prolonged Storage on Coagulation Factor (F)V, FVII, and FVIII in Thawed Plasma: Is It Time to Extend the Expiration Date Beyond 5 Days. Transfusion. 53(3): 645-650, 2013.

KJ Welsh, E Nedelcu, Y Bai, A Wahed, K Klein, H Tint, I Gregoric, M Patel, B Kar, P Loyalka, et al: How do We Manage Cardiopulmonary Bypass Coagulopathy? Transfusion. 54(9): 2158-2166, 2014.

R Huang, E Nedelcu, Y Bai, A Wahed, K Klein, I Gregoric, M Patel, B Kar, P Loyalka, S Nathan, et al: Mobile Computing Platform with Decision Support Modules for Hemotherapy. American Journal of Clinical Pathology. 141(6): 834-840, 2014.

R Huang, E Nedelcu, Y Bai, A Wahed, K Klein, I Gregoric, M Patel, B Kar, P Loyalka, et al. Post-Operative Bleeding Risk Stratification in Cardiac Pulmonary Bypass Patients Using Artificial Neural Network. Annals of Clinical and Laboratory Science. 45(2): 181-186, 2015.

Books
A Dasgupta and K Klein: Antioxidants in Foods, Vitamins, and Supplements: prevention and Treatment of Disease. Elsevier, 2014.

Additional Information

Committees
Faculty compensation committee

Transfusion Committee Memorial Herman Hospital