Education

MD
Aleppo University Faculty of Medicine, Aleppo, Syria, 1982
Visiting Fellow
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 1985-1987
Residency (Pathology)
Yale University School of Medicine, Department of Pathology, New Haven, CT 1987-1992
Fellowship (Gastrointestinal Pathology)
Baylor College of Medicine, Department of Pathology, Houston, TX 1990-1992

Areas of Interests

Clinical Interests

Gastrointestinal and Liver Pathology, Immunohistochemistry, Biomarkers, Digital Image Analysis, Inflammatory Bowel Disease, Barrett’s Esophagus (Barrett’s Metaplasia), Premalignant and malignant lesions of the GI tract, liver, and pancreas.

Publications

Publication Information

Representative  Recent Publications

Younes M, Brown K, Lauwers GY, Ergun G, Meriano F, Schmulen AC, Barrosos A, Lechago J, Ertan A. p53 protein accumulation predicts malignant progression in Barrett’s metaplasia: a prospective study of 275 patients. Histopathology,  2017 Feb 22. doi: 10.1111/his.13193.

Bailey JM, Hendley AM, Lafaro KJ, Pruski MA, Jones NC, Alsina J, Younes M, Maitra A, McAllister F, Iacobuzio-Donahue CA, Leach SD. p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cell. Oncogene, 2016; 35:4282-4288.

Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds AB, Goggins M, Younes M, Iacobuzio-Donahue CA, Leach SD, Bailey JM. p120 Catenin suppresses basal epithelial cell extrusion in invasive pancreatic neoplasia. Cancer Res 2016; 76:3351-3363.

Tyson GL, Ilyas J, Duan Z, Green LK, Younes M, El-Serag HB, Davila JA. Secular Trends in the Incidence of Cholangiocarcinoma in the United States and the Impact of Misclassification. Digestive Diseases and Sciences (2014) 59:3103–3110 .

Nguyen T, Tang Z, Younes M, Alsarraj A, Ramsey D, Fitzgerald S, Kramer JR, El-Serag HB. Esophageal COX-2 expression is increased in Barrett’s esophagus, obesity, and smoking. Dig Dis Sci 2015; 60:65-73.

Zhang S, Marin-Muller C, Younes M, Liu H, Chen C, Yao Q. Reduced Selenium-binding Protein 1 in Breast Cancer Correlates with Poor Survival and Resistance to the Anti-proliferative Effects of Selenium. PloS One 2013, vol. 8 (5) p. e63702.

Vill NA, El-Serag HB, Younes M, Ertan A. Esophageal Eosinophilia After Radiofrequency Ablation for Barrett’s Esophagus. Dis Esophagus 2013; 26:674-677.

El-Serag HB, Hollier JM, Gravitt P, Alsarraj A, Younes M. Human Papilloma virus and risk of Barrett’s esophagus. Dis Esophagus 2013; 26:517-521.

Nordenstedt H, Younes M, El-Serag H. Expression of androgen receptors in Barrett esophagus. J Clin Gastroenterol 2012; 112:249-258.

Younes  M, Lauwers G, Ertan A, Ergun G, Verm R, Bridges M, Woods K, Meriano F, Schmulen C, Colman R, Johnson C, Barroso A, Schwartz J, Ball D, McKechnie J, Lechago J. The significance of indefinite for dysplasia grading in Barrett’s metaplasia. Arch Pathol Lab Med 2011;135:430-432.

Honma N, Horil R, Iwase T, Saji S, Younes M, Takubo K, Matsuura M, Ito Y, Akiyama F, Sakamoto G. Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. J Clin Oncol 2008; 26:3727-3734.