The Fluorescence Microscopy and Imaging Core Laboratory is a multi-user facility located in the Department of Pathology and Laboratory Medicine at McGovern Medical School Houston, within the Texas Medical Center.
Its purpose is to allow research scientists access to state of the art Fluorescence Microscopes and Imaging equipment, to foster experimentation for the further understanding of scientific phenomena in many diverse areas of clinical and basic research.
The lab houses 4 Wide-Field inverted Epi-Fluorescence Microscopes and features a DeltaVision Deconvolution Microscopy System (Applied Precision Inc.) for 3-D rendering of up to 5 separate targets (Wavelengths/Probes) simultaneously, with subsequent Quantitative Image Analysis (SoftWoRx® Imaging Software), volume rotations (Exported as MPEG or AVI Files) and computer generated models. The Facility also features a Live-Cell Imaging System (PCI®) capable of capturing 3 wavelengths (probes) simultaneously, together with high speed image acquisition (up to 1000 frames per second) of single wavelength probes and/or multi-wavelength probes (Ratio of Dual Emission) for measuring ionic concentrations such as Calcium, Magnesium, Potassium concentrations and pH.
Various environmental chambers are available for long-term fluorescence studies in such environments as hypoxia, hyperthermia and cold temperatures. Other imaging capabilities include Bright-Field Microscopy (Color and Grayscale), simultaneous fluorescence and Bright-Field image acquisition and standard Histology slide scanning. We welcome local, national and international researchers with the hope that they will use these facilities to foster symbiotic and collaborative undertakings.