McGovern Medical School

komatsu
Contact Info
Yoshihiro.Komatsu@uth.tmc.edu

Academic Office
(713) 500-5783

Assistant Professor

Education & Background

Graduate School
Kumamoto University
Kumamoto, Japan
2004
Postdoctoral Fellowship
University of Michigan
Ann Arbor, MI
2009-2012

Interests

Research Interests
Our research interests are in the genetic and molecular mechanisms that orchestrate embryonic development. Our lab focuses on two fields: ciliopathies and craniofacial skeletal defects. We found that bone morphogenetic protein (BMP) signaling regulates the transient formation of cilia at the node, the critical component required to establish the left-right asymmetry. We also found that augmentation of BMP signaling altered the skeletogenic cell fate in neural crest cells that leads to skull shape abnormalities. Our study will identify the previously uncharacterized molecular mechanisms that will allow for the development of new therapeutic directions for birth defects and craniofacial bone-related treatment.

Publications

Noda K, Shiozawa Y, Komatsu Y. Molecular etiology of craniosynostosis. Genet Disord Gene Ther. 2013, 1: 101.

Komatsu Y, Yu PB, Kamiya N, Fukuda T, Ray MK, Yamamura KI, Mishina Y. Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice. Journal of Bone and Mineral Research. 2013, 28, 1422-1433.

Komatsu Y, Mishina Y. Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos. Cellular and Molecular Life Sciences. 2013, 70, 4659-4666.

Komatsu Y, Kaartinen V, Mishina Y. Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry. Development. 2011, 138, 3915-3920.

Komatsu Y, Scott G, Nagy A, Kaartinen V. Mishina Y. BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. Developmental Dynamics. 2007, 236, 512-517.

Lab Information

Kazuo Noda, M.D., Ph.D., Postdoc Research Fellow, (713) 500-5941, Kazuo.Noda@uth.tmc.edu

Jingling Shen, PhD., Postdoc Research Fellow, (713) 500-5941, Jingling.Shen@uth.tmc.edu

Megumi Kitami, D.D.S., Ph.D.; Postdoc Research Fellow, (713) 500-5941, Megumi.Kitami@uth.tmc.edu