Graduate School
Peking University Health Science Center (Beijing Medical University, Beijing, China, 1998
University of Texas M. D. Anderson Cancer Center, Houston, Texas, 1999 - 2004

Areas of Interests

Clinical Interests

Our clinical research focuses on colic, which we showed to be an inflammatory condition of babies who cry excessively. We are analyzing the circulating Treg cells, inflammatory biomarkers, microbiota, and fecal calprotectin in babies treated with Lactobacillus reuteri versus placebo in a “road to discovery” trial (NIH R34 AT 006727).  We hope to initiate a similar Phase I trial in children with autism spectrum disorders and gastrointestinal symptoms.

Research Interests

Our research interests focus on neonatal intestinal inflammation and the impact of probiotics.  We are (1) investigating immune responses during neonatal necrotizing enterocolitis (NEC), which is a leading cause of gastrointestinal morbidity and mortality in premature infants; (2) determining the mechanisms by which probiotic Lactobacillus reuteri regulates intestinal inflammation.  We are using NEC and Treg-deficient mice to better understand how the immune cells including TH1, TH17, Treg, and dendritic cells respond to probiotics, and which cells control the level of gastrointestinal inflammation in the newborn.  In addition, we are studying how breast milk factors may potentiate the effect of Lactobacillus reuteri on immune cell differentiation (NIH/NCCAM 1R01 AT 007083).


Publication Information

1. He B, Hoang TK, Wang T, Ferris M, Taylor CM, Tian X, Luo M, Tran DQ, Zhou J, Tatevian N, Luo F, Molina JG, Blackburn MR, Gomez TH, Roos S, Rhoads JM, and Liu Y. Resetting microbiota by Lactobacillus reuteri inhibit T reg deficiency-induced autoimmunity via adenosine A2A receptors. The Journal of Experimental Medicine. DOI: 10.1084/jem.2016096. 2016.

2. Schuck-Phan A, Phan T, Dawson PA, Dial EJ, Bell C, Liu Y, Rhoads JM, and Lichtenberger LM. Formula Feeding Predisposes Gut to NSAID-Induced Small Intestinal Injury. Clin Exp Pharmacol 6:222. doi: 10.4172/2161-1459.1000222, 2016.

3. Liu Y, Hoang TK, Wang T, He B, Tran DQ, Zhou J, Tatevian N, Rhoads JM. Circulating L-selectin expressing–T cell subsets correlated with the severity of Foxp3 deficiency autoimmune disease. Int J Clin Exp Pathol. 9(2):899-909, 2016.

4. Navarro F, Liu Y, and Rhoads JM. Can probiotics benefit children with autism spectrum disorders? World J Gastroenterol. 22 (46): 10093-10102, 2016.

5. Van Arsdall M, Haque I, Liu Y, and Rhoads JM. Is there a role for the enteral administration of serum-derived immunoglobulins in human gastrointestinal disease and pediatric critical care nutrition? Advances in Nutrition. 7: 535-543, 2016.

6. Liu Y, Tran DQ, Fatheree NY,and Rhoads JM. Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+regulatory T cells in a mouse model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 307: G177-G186, 2014.

7. Liu Y, Fatheree NY, Dingle BM, Tran DQ, and Rhoads JM. Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3+ regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis. PloS ONE 8 (2): e56547, 2013.

8. Chapman JC, Liu Y, Zhu L, and Rhoads JM. Arginine and citrulline protect intestinal cell monolayer tight junctions from hypoxia-induced injury in piglets. Pediatric Research. 72(6): 576-582, 2012.

9. Liu Y, Fatheree NY, Mangalat N, Rhoads JM. Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NFkB signaling in the intestine. Am J Physiol Gastrointest Liver Physiol. 302: G608-G617, 2012.

10. Mangalat N*, Liu Y*, Fatheree NY, Ferris MJ, Van Arsdall MR, Chen Z, Rahbar MH, Gleason WA, Norori J, Tran DQ, and Rhoads JM. Safety and tolerability of Lactobacillus reuteri DSM 17938 and effects on biomarkers in healthy adults: results from a randomized masked trial. *authors are equally contributed to this research. PLoS ONE 7 (9): e43910, 2012.

11. Liu Y, Zhu L, Fatheree NY, Liu X, Pacheco SE, Tatevian N, and Rhoads JM. Changes in intestinal toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 297: G442-G450, 2009.