Nilesh S. Tannu, MD, MS, assistant professor of psychiatry, provides clinical care at UT Physician Outpatient Clinics in Cinco Ranch and Sienna Village. A board-certified adult psychiatrist, his clinical interests involve the psychopharmacological management of addiction, depression, bipolar disorder, anxiety spectrum disorders, ADHD, and psychotic disorders. A key challenge in understanding substance use disorders has been to know why some individuals become addicted when exposed to drugs, whereas some do not. Over the years there have been significant leaps in our understanding of the neuroscience associated with the substance use disorders. In spite of these advances, what has evaded us in finding an effective treatment plan brings up the debate on the molecular basis of development, synaptic wiring, environment, and something more. There have been many studies which have explored the utility of various neurotransmitter targets for treating stimulant dependence. There is, however, no definitive and standard treatment approved by regulatory authorities for cocaine dependence.

Tannu is also interested to understand the neurobiological mechanisms of cocaine pharmacotherapy that are currently being proposed, and at the same time develop the bio signatures reflective of subset of patients ranging from dependence to treatment outcomes during treatment. Some of his past research studies have utilized targeted proteomic approaches to determine changes in protein networks and biochemical cascades as a function of drug history and putative treatment strategies.


Medical Degree
B. J. Medical College, Pune, India
Graduate Degree
Biomedical Engineering, The University of Tennessee Health Science Center
Research Fellowship
Addiction Psychiatry, Wake Forest School of Medicine
Psychiatry, The University of Texas Health Science Center at Houston

Areas of Interest

Clinical Interests

  • Addiction
  • Adult General Psychiatry
  • Anxiety/OCD
  • Autism
  • Bipolar Disorder
  • Depression
  • Developmental & Intellectual Disabilities
  • Eating Disorders
  • Geriatric Psychiatry
  • PTSD
  • Schizophrenia
  • Second Opinion

Research Interests

  • Community Mental Health
  • Genetics
  • Molecular Psychiatry
  • Mood Disorders
  • Psychopharmacology
  • Relapse Prevention