MSB 2.103
Thursday, December 05, 2013, 9:00 a.m. - Noon

Inflammation – Double Edge Sword in Disease Pathogenesis

Inflammation is a fundamental part of the body’s immune response to tissue injury or to foreign stimuli such as chemical irritants, pathogenic organisms, and fungi.  The inflammatory response is critical in removing the injurious substances and in repairing the damaged tissues.  Despite its importance in host defense and wound healing, inflammation is also a “double-edged” sword.  Dysregulated or chronic inflammation can lead to numerous debilitating diseases, including Alzheimer’s, atherosclerosis, stroke, asthma, COPD, rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.  It is critical therefore to develop appropriate strategies that could be applied therapeutically to abrogate the deleterious aspects of inflammation without impairing the important immune and healing properties provided by a well regulated immune response.  To do so will require a thorough understanding of the incredibly complex communications network of cells, molecular mediators, and various signal pathways and feedback loops that initiate and regulate the inflammatory response.  This workshop will focus on recent novel discoveries that provide important insights into key unresolved mechanisms in understanding how inflammation mediates disease pathogenesis.

December 5, 2013

9:00 a.m. – Noon, MSB 2.103
Chaired by Rick Wetsel, Ph.D., Immunology and Autoimmune Research Center, UTHealth Medical School

Speakers:

Jaroslaw Aronowski, M.D., Ph.D., Department of Neurology – Vascular Neurology Program, UTHealth Medical School
“Yin and yang of cerebral inflammation after stroke-complexity infinitus”      

Michael Blackburn, Ph.D., Department of Biochemistry and Molecular Biology, UTHealth Medical School
“Role of adenosine signaling and inflammation in the progression of chronic lung disease”

Yeonseok Chung, Ph.D. Immunology and Autoimmune Research Center, UTHealth Medical School

“Role of inflammatory T-cells in the cross-regulation between atherosclerosis and autoimmunity

Amber Luong, M.D., Ph.D. Department of Otorhinolaryngology-Head and Neck Surgery, UTHealth Medical School

“Novel therapeutic targets within the innate immune response of chronic respiratory disease”