Areas of Interest
Research Interests
My long- term research interest in Dr. Xiaochao Tan’s lab is to elucidate how the tumor microenvironment drives lung cancer progression and metastasis, with a particular focus on how proteins in the endoplasmic reticulum and Golgi apparatus regulate the tumor microenvironment and, in turn, influence lung cancer progression. By defining these mechanisms, my research aims to identify novel therapeutic targets and develop innovative strategies for the treatment of lung cancer.
Publications
- Shike Wang, Na Ding, Angelo Chen,Derrick Cardin, Yuting Xu, Kate Grimley,William K. Russell, Jun Xu, Jonathan M. Kurie, Guan-Yu Xiao, and Xiaochao Tan. Endoplasmic reticulum–resident α-glucosidase II drives non-small cell lung cancer progression via regulation of secretory glycoproteins. JCI Insight. 2026;11(11):e203262.
- Wang S, Xiao GY, Tan X. QSOX1: A Mysterious Golgi-Localized Disulfide Bond Catalyst and an Emerging Cancer Regulator. (external link)Cancers (Basel). 2026 Jan 21;18(2). doi: 10.3390/cancers18020339. PubMed PMID: 41595257; PubMed Central PMCID: PMC12839041.
- Xiaochao Tan*, Derrick L Cardin*, Shike Wang*, Yuting Xu, William K Russell. Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH–dependent exocytosis of GOLIM4. Proceedings of the National Academy of Sciences. 2025 Jul 15;122(28). (*contributed equally).
- Shike Wang, Houfu Guo, Reo Fukushima, Masahiko Terajima, Min Liu, Guan-Yu Xiao, Lenka Koudelková, Chao Wu, Xin Liu, Jiang Yu, Emma Burris, Jun Xu, Alvise Schiavinato, William K. Russell, Mitsuo Yamauchi, Xiaochao Tan, and Jonathan M. Kurie. J Clin Invest. 2025;135(7):e189197.
- Xiaochao Tan*, Shike Wang*, Guan-Yu Xiao, Chao Wu, Xin Liu, Biyao Zhou, Yu Jiang, Dzifa Y. Duose, Yuanxin Xi, Jing Wang, Kunika Gupta, Apar Pataer, Jack A. Roth, Michael P. Kim, Fengju Chen, Chad J. Creighton, William K. Russell, and Jonathan M. Kurie. Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. J Clin Invest. 2024;134(12):e176355. (*contributed equally).
- Xiao GY, Tan X, Rodriguez BL, Gibbons DL, Wang S, Wu C, Liu X, Yu J, Vasquez ME, Tran HT, Xu J, Russell WK, Haymaker C, Lee Y, Zhang J, Solis L, Wistuba II, Kurie JM. EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancer. (external link)Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2220276120.
- Xiaochao Tan, Guan-Yu Xiao, Shike Wang, Lei Shi, Yanbin Zhao, Xin Liu, Jiang Yu, William K Russell, Chad J Creighton, Jonathan M Kurie.EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer.J Clin Invest. 2023 Feb 9;e165863.