Associate Professor, Neurobiology & Anatomy
Dr. Liu was born and raised in China. She received her bachelor’s degree in Biology from the University of Science and Technology of China. After that, she came to the States to pursue graduate studies. She obtained her Ph.D. in Computational Biology and Bioinformatics from Yale University with Dr. Hongyu Zhao, focusing on statistical modeling of biological networks. Subsequently, she joined the University of Texas Health Science Center and set up her own research group in 2007. Within the domain of Bioinformatics, her laboratory develops computational and statistical methods to understand how biological interactions modulate complex signaling responses that are involved in common cancers and neurological diseases. Dr. Liu has served as the program committee members for a number of scientific conferences and is a frequent journal reviewer in the field of Bioinformatics and Systems Biology. She has participated in grant reviews for a variety of funding agencies, including NIH, NSF, AAAS and Microsoft.
Computational Biology and Bioinformatics
My research interests lie in the field of Computational Biology and Bioinformatics, which involves developing statistical and computational methods to systematically characterize how biological interactions modulate complex biological responses.
The research in our group primarily focuses on the development of sound statistical models to integrate information from diverse sources in order to reconstruct biological networks, such as protein interaction networks. In the area of genome-wide protein interaction prediction, the high-throughput techniques such as yeast two-hybrid screening methods used for systematically identifying protein interactions suffer from high false positive rates and high false negative rates due to the limitation of these techniques. We have been working on developing statistical methods to integrate large-scale protein interaction data from diverse organisms in order to improve the reliability of protein interactions inference. Another topic in the area of systems biology we are interested in is signal transduction pathway reconstruction. We have developed an approach that integrates protein-protein interaction data and gene expression data from microarray chips for predicting the order of signaling pathway components, assuming all the components on the pathways are known. Our current research on this topic concentrates on the incorporation of other types of information such as protein phosphorylation data, and the development of more elaborate statistical approaches to make further prediction and modeling of the signal transduction networks.
From a statistical point of view, we are interested in the field of Bayesian inference and its applications in Bioinformatics. Bayesian inference has been widely used in the analysis of high throughput bioinformatics data because biological evidence can be flexibly incorporated into Bayesian models and it naturally lends itself to efficient computational methods. Currently, we are working on the development of a Bayesian approach coupled with Markov Chain Monte Carlo (MCMC) to inferring protein complexes and functional modules using high-throughput mass spectrometry data, with considering the topological structures of the protein interaction networks when making the inference.
- Wang, Z., Xu, W., San Lucas, F. and Liu, Y.: Incorporating prior knowledge into gene network study, Bioinformatics, 29: 2633-40, 2013.
- Wang, Q., Zhang, P., Hoffman, L., Tripathi, S., Homouz, D., Liu, Y., Waxham, M.N., and Cheung, M.: Protein recognition and selection through conformational and mutually induced fit. Proc Natl Acad Sci USA, 110(51): 20545–20550, 2013.
- Wang, Z., San Lucas, F., Qiu, P., and Liu, Y.: Improving the sensitivity of sample clustering by leveraging gene co-expression networks in variable selection. BMC Bioinformatics, 15(1):153, 2014. (*Highly accessed paper)
- Xu, W., San Lucas, F., Wang, Z., and Liu, Y.: MicroRNA target prediction based on analysis of coding sequences and untranslated regions. BMC Bioinformatics, 15:S4, 2014.
- Xu, W., Wang, Z., and Liu, Y.: The characterization of microRNA-mediated gene regulation as impacted by both target site location and seed match type. PLoS One, 9(9): e108260, 2014.
- Wang Z., Qiu, P., Xu, W., and Liu, Y.: Spectral feature selection and its application in high dimensional gene expression studies. Proceedings of 2014 ACM conference on Bioinformatics, Computational Biology and Health (ACM BCB’14), 314-320, 2014.
- Wang, Z., Xu, W., Zhu, H., and Liu, Y.: A Bayesian framework to improve microRNA target prediction by incorporating external knowledge, Cancer Informatics, S7, 19-25, 2014.
- Xu, W., and Liu, Y.: mHealthApps: Mobile Health Application Repository. Journal of Medical Internet Research mHealth and uHealth. 3(1): e28, 2015.
- Wang, Z., Xu, W., and Liu, Y.: Integrating full spectrum of sequence features into predicting functional microRNA-mRNA interactions. Bioinformatics, 31(21), 3529-3536, 2015.
- Tripathi, S., Waxham, M.N., Cheung, M., and Liu, Y.: Lessons in protein design from combined evolution and conformational dynamics. Scientific Reports, 5, 14259, 2015.
- Wang, Z., Xu, W., and Liu, Y.: Systematic and Integrative Analysis of Gene Expression to Identify Feature Genes Underlying Human Diseases. Transcriptomics and Gene Regulation, 161-185, 2016.