Dr. Buja is engaged in scholarly investigation, educational activities and clinical service while also serving in leadership roles. His subspecialty interest is cardiovascular pathology with research interests in myocardial cell injury, myocardial ischemia, atherosclerosis and cardiomyopathies. Dr. Buja teaches medical students, medical residents, clinical fellows, graduate students and research post-doctoral fellows.
He also conducts a clinical practice in cardiovascular and pulmonary pathology providing staffing of autopsy cases and surgical pathology consultation of cardiac and vascular cases and interpretation of myocardial biopsies from referrals. He directs a cardiovascular pathology fellowship approved by the Texas Medical Board. Since the establishment of an Advanced Heart Failure Center on campus, he has served as the cardiovascular pathologist for the Center and has provided staffing for over 100 heart transplants, numerous LVADs, and post-transplant myocardial biopsies for evaluation and grading of antibody-mediated and acute cellular rejection. Dr. Buja serves as a consultant in cardiovascular pathology for the Harris County Institute of Forensic Sciences. He serves as the Director of the DPALM Autopsy Service at the affiliated teaching hospitals and has been an advocate of the importance of the autopsy as a tool in medical research and quality control in healthcare. He is the editor-in-chief of Cardiovascular Pathology, the official journal of the Society for Cardiovascular Pathology.
- Senior Investigator, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD, 1974
- Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD, 1972
- Staff Associate
- Pathology, National Heart and Lung Institute, NIH, Bethesda, MD, 1970
- Mixed Medicine, Charity Hospital, New Orleans, LA
- Anatomy, Tulane University, New Orleans, LA, 1968
- M.D., with Honors
- Tulane University, New Orleans, LA, 1967
- Biology, Loyola University of the South, New Orleans, LA, 1964
Areas of Interest
My clinical interests are in autopsy and cardiovascular pathology.
My research interest is focused on the pathobiology of cardiovascular diseases, especially atherosclerosis, ischemic heart disease and cardiomyopathies. I also have a broad interest in mechanisms of cell injury. I have experience in research in cell systems and experimental models as well as in clinicopathological studies.My current research is on the pathology of cardiac remodeling in patients with advanced heart failure based on studies of explanted hearts and LV core samples obtained at the time of LV assist device placement. I also am interested in the effects of cell-based therapy for heart failure.
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- Buja LM, Krueger GRF. Netter’s Illustrated Human Pathology. Teterboro, NJ: Icon Learning Systems; 2005. Second edition, Elsevier, 2014.
- Krueger GRF, Buja LM, Chandrasekhar C (Editors). Atlas of Anatomic Pathology with Imaging. London: Springer; 2013.
- Buja LM. The pathobiology of acute coronary syndromes: clinical implications and central role of the mitochondria. Texas Heart Inst J. 2013; 40:221-228.
- Gahremanpour A, Vela D, Zheng Y, Silva GV, Fodor W, Cardoso CO, Baimbridge F, Fernandes MR, Buja LM, Perin EC. Xenotransplantation of human unrestricted somatic stem cells in a pig model of acute myocardial infarction. Xenotransplantation 2013; 20:110-122.
- Segura AM, Frazier OH, Demirozu Z, Buja LM. Histopathologic correlates of myocardial improvement in patients supported by a left ventricular assist device. Cardiovasc Pathol. 2011; 20: 139-145.
- Buja LM, Vela D. Cardiomyocyte death and renewal in the normal and diseased heart (Review article). Cardiovasc Pathol. 2008;17:349-374.
- Buja LM, Butany J. (Editors) Cardiovascular Pathology, 5th Editon. New York: Elsevier; January 2022.
- Buja LM. Pathobiology of myocardial ischemic injury and reperfusion injury: models, modes, molecular mechanisms, modulation and clinical applications. Cardiol Rev. 2022 Feb 16. doi: 10.1097/CRD.0000000000000440. Epub ahead of print. PMID: 35175958.
- McDonald M, Mihalj M, Zhao B, Nathan S, Matejin S, Ottaviani G, Jezovnik MK, Radovancevic R, Kar B, Gregoric IC, Buja LM. Clinicopathological correlations in heart transplantation recipients complicated by death or re-transplantation. Front Cardiovasc Med 2022;9:1014796. Doi:10.3389/fcvm.2022.1014790.
- Jyothula SSK, Peters A, Liang Y, Bi W, Shivshankar P,Yau S, Garcha PS, Yuan X, Akkanti B, Collum S, Wareing N, Thandavarayan RA, Poli de Frias F, Rosas IO, Zhao B, Buja LM, Eltzschig HK, Huang HJ, Karmouty-Quintana H. Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation. EBIOM. 2022:86:104351. Doi:org./1016/j.ebom.2022.104351
Anatomic Pathology, American Board of Pathology, November 1972, Recertified January 1997 and January 2007
Harlan J. Spjut Award, Houston Society of Clinical Pathologists, 1997
George T. Caldwell,MD Distinguished Service Award, Texas Society of Pathologists, 2005
Founding Member and President, The University of Texas Kenneth I. Shine MD Academy of Health Science Education
Outstanding Alumnus Award, Tulane Medical Alumni Association, 2008
Distinguished Achievement Award, Society for Cardiovascular Pathology, 2009
UT Health President Scholar Award for Excellence in Teaching, 2014