Histology
Certain biopsy types including fascia, heart, liver, lung, muscle, nerve, renal, and skin biopsies require special handling and need to be coordinated with the performing laboratory. Please call 713-500-5324 before collecting one of these biopsy types to get special collection and transport instructions.
Collection of other specimen types:
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- Use care to not crush any biopsy or specimen collection during the collection process.
- All specimen should be immediately placed in 10% neutral buffered formalin. Proper formalin to specimen ratio is 10:1. Do not force large specimen into small containers.
- Each separately identified specimen should be given its own container and labeled with the date, time, and site of collection.
- Only one requisition is necessary per patient, but should list each individual specimen collected and the collection site. This information should exactly match what is recorded on each specimen container.
- Please contact UTPath at 713-500-5255 or utpath@uth.tmc.edu for supplies.
UTPath will perform grossing, frozen sections when requested or indicated, processing, embedding in paraffin, microtomy, staining and Pathologist diagnostic review on biopsies and surgical resections.
For questions regarding “Technical Component Only” or “Professional Component Only” please contact UTPath at 713-500-5401.
Currently available IHC Stains include:
| IHC Stains | ||
|---|---|---|
| ACTH | Actin (MSA/Muscle Specific Actin) | Adenovirus |
| Adhalin | AE1/AE3 (CK AE1/AE3, Pankeratin) | ALK-1 Protein (CD246) |
| ALK-1 D5F3 | Alpha Fetoprotein (AFP) | Alpha-1-Antitrypsin |
| Alpha-Synuclein | Amyloid A | Androgen Receptor |
| Arginase-1 | ATRX | B72.3 (TAG-72) |
| BAX | Beta Amyloid | Beta Catenin |
| Beta Dystroglycan | BCL-2 | BCL-6 |
| BCL-10 | BerEP4 | Brachyury |
| BRAF (V600E) | BRG (SMARCA4) | C3d |
| C4d | C5b9 | CA-125 (MUC 16) |
| Calcitonin | Calrectin | Carbonic Anhydrase (CAIX) |
| CAM 5.2 (CK8) | Caveolin-1 | Caveolin-3 |
| CD1a | CD2 | CD3 |
| CD4 | CD5 | CD7 |
| CD8 | CD10 | CD15 (Leu-M1) |
| CD20 | CD21 | CD23 (FC Epsilon RII) |
| CD30 | CD31 | CD34 |
| CD38 | CD43 (Leukosialin/Ly48) | CD44 |
| CD45 (LCA) | CD56 (NCAM) | CD57 (Leu7) |
| CD61 (Platelet Glycoprotein IIIa) | CD68 | CD79a (MB-1) |
| CD99 (MIC/Ewing’s Sarcoma) | CD117 (c-kit) | CD138 (Syndecan-1/SDC1) |
| CDX-2 | CEA (mono) | CEA (poly) |
| Chromogranin A | CK Pan (Pan-cytokeratin) | CKHMW (34BE12) |
| CK5/6 | CK7 (K7/SCL) | CK14 |
| CK19 (K19) | CK20 | Claudin 18 |
| Collagen III | Collagen IV | Collagen VI |
| COVID19 (Research Only) | COX-2 | C-Reactive Protein (CRP) |
| C-term | Cyclin D1 (Bcl-1) | Cytomegalovirus (CMV) |
| D2-40 | Desmin | DOG-1 |
| Dysferlin | Dystrophin (N-terminus) | E-Cadherin |
| EGFR | Emerin | Epithelial Membrane Antigen (EMA) |
| Epstein Barr Virus (EBV-LMP) | ERG | Estrogen Receptor Alpha |
| Estrogen Receptor EP1 (88360) | FABP | Factor 8 Related Antigen |
| Factor 13a | Fast Myosin | FSH |
| Gamma Sarcoglycan | Gastrin | GATA 3 |
| GCDFP (BRST-2) | Chromogranin A | Glial Fibrillary Acidic Protein (GFAP) |
| Glucagon | GLUT-1 | Glutamin Synthetase |
| Glypican 3 (GPC3) | H3K27M | Helicobactor Pylori |
| HBME-1 | HCG | HepPar1 (Hepatocyte Specific Antigen) |
| Hepatitis B Core Antigen | Hepatitis B Surface Antigen | Herpes Simplex Virus I&II (HSV) |
| HHV-8, HSP70 | Human Melanoma (HMB45) | Human Papilloma Virus (HPV) |
| IDH1 p.R132H | IgG | IgG4 |
| IMP3 | Inhibin | INI1 (BAF47) |
| Insulin | INSM1 | Kappa |
| Ki67 | Ki67 (88360) | Lambda |
| LH | Mart-1 (Melan A) | Maspin |
| Mast Cell Tryptase | Merosin | MHC-Type1 |
| Mid-Rod Dystrophin | MITF | MOC31 |
| MSI Panel (MLH1/MSH2/ MSH6/PMS2) | MUC1 | MUC2 |
| MUC4 | MUC5AC | MUC6 |
| MUM-1 (IRF4) | Myeloperoxidase (MPO) | Myogenin |
| Myglobin | Mysin Heavy Chain (SMMS-1) | Napsin A |
| Nestin | Neu-N | Neurofilament (NF) |
| NKX3.1 | NSE | N-Cadherin |
| NUT (C52B1) | p16 | p16 |
| p27 | p40 | p53 bp-53-12-1 (Biogenix) |
| p53 DO7 | p63 | p504s (Racemase/AMARC) |
| Pan Trk | Parvovirus | PAX-5 (BSAP) |
| PAX-8 | PHH3 | PIN Cocktail (p63 & p504s Doublestain) |
| PgR/Progesterone Receptor | PgR 1294 (88360) | Placental Alkaline Phosphatase (PLAP) |
| Prolactin | Prostate Specific Antigen (PSA) | Prostatic Acid Phosphatase (PAP) |
| PTH (Parathyroid Hormone) | Renal Cell Carcinoma (RCC) | ROS1 |
| S100 Protein | S100P (S100 calcium-binding Protein P) | SALL4 |
| SDhB | SF-1 | SMA Alpha (Smooth Muscle Actin) |
| Sox10 | Spectrin | Spirochete (T. pallidum) |
| STAT6 | SV-40 T Antigen | Synaptophysin |
| Tau | Tdt (DNTT) | Thyroglobulin |
| Thymidylate Synthase (TS) | Topoisomerase II alpha (Topo IIa) | Toxoplasma |
| TSH | TTF-1 | Ubiquitin |
| Varicella | VEGF | Villin |
| Vimentin | Wilm’s Tumor (WT1) | YAP1 |
Currently available Special Stains:
| AFB, Fite | AFB, Fite | Alcian Blue pH 2.5 |
| Congo Red (Amyloid) | Copper | Diff-Quik |
| Elastic | GMS Fungus | GMS-Diastase |
| Gram Stain | Hall’s Bilirubin (Bile) | Iron |
| Iron, Colloidal | Luxol Fast Blue | Mucicarmine |
| PAS | PAS-Diastase | Reticulin |
| Trichrome | Von Kossa (Calcium) | Warthin-Starry |
| Jones | Oil Red O | NADH |
| Trichrome Gomori | Myophosphorylase | Cytochrome C |
| NSE | ATPase 4.3 | ATPase 4.6 |
| ATPase 9.4 | Acid Phosphatase | SDH |
Currently available Immunoflourescence:
| Albumin | Alport’s Syndrome | C1q |
| C3 | C4d | DNAJB9 |
| Fibrinogen | IgA | IgG |
| IgG Subtypes | IgM | Kappa |
| Lambda | PLA2R |
PharmDx Kits (FDA Approved):
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- Hercept Test (HER2 IHC)
- PD-L1 22C3
- Her-2-neu (FISH)
Chromogenic In-Situ Hybridization:
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- EVER-1 (Epstein Barr Virus/EBV)
- HPV ISH (HR Cocktail+HPV16/18)
- Kappa ISH
- Lambda ISH