Publications

Kim HS, Hardiman MM, Pickering AM. Protein translation rates are negatively correlated with lifespan in in-bred Drosophila strains. J Gerontol A Biol Sci Med Sci. 2024 Dec 13;. doi: 10.1093/gerona/glae289. [Epub ahead of print] PubMed PMID: 39670875.

Davidson K, Bano M, Parker D, Osmulski P, Gaczynska M, Pickering AM. β-Amyloid impairs Proteasome structure and function. Proteasome activation mitigates amyloid induced toxicity and cognitive deficits. bioRxiv. 2024 Oct 25;. doi: 10.1101/2024.10.23.619877. PubMed PMID: 39484574; PubMed Central PMCID: PMC11526959.

Pickering AM. Altered Proteasome Composition in Aging Brains, Genetic Proteasome Augmentation Mitigates Age-Related Cognitive Declines, and Acute Proteasome Agonist Treatment Rescues Age-Related Cognitive Deficits in Mice. bioRxiv. 2024 Oct 20;. doi: 10.1101/2024.10.17.618893. PubMed PMID: 39463960; PubMed Central PMCID: PMC11507914.

Pickering CEZ, Winstead V, Yildiz M, Wang D, Yefimova M, Pickering AM. Subsyndromes and symptom clusters: Multilevel factor analysis of behavioral and psychological symptoms of dementia with intensive longitudinal data. Alzheimers Dement. 2024 Oct;20(10):6699-6708. doi: 10.1002/alz.14075. Epub 2024 Aug 15. PubMed PMID: 39145506; PubMed Central PMCID: PMC11485321.

Kim HS, Parker DJ, Hardiman MM, Munkácsy E, Jiang N, Rogers AN, Bai Y, Brent C, Mobley JA, Austad SN, Pickering AM. Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling. Nat Commun. 2023 Aug 18;14(1):5021. doi: 10.1038/s41467-023-40618-x. PubMed PMID: 37596266; PubMed Central PMCID: PMC10439225.

Davidson K, Pickering AM. The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease. Front Cell Dev Biol. 2023;11:1124907. doi: 10.3389/fcell.2023.1124907. eCollection 2023. Review. PubMed PMID: 37123415; PubMed Central PMCID: PMC10133520.

Kim HS, Pickering AM. Protein translation paradox: Implications in translational regulation of aging. Front Cell Dev Biol. 2023;11:1129281. doi: 10.3389/fcell.2023.1129281. eCollection 2023. Review. PubMed PMID: 36711035; PubMed Central PMCID: PMC9880214.

Chocron ES, Munkácsy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models. Sci Adv. 2022 Jun 10;8(23):eabk2252. doi: 10.1126/sciadv.abk2252. Epub 2022 Jun 8. PubMed PMID: 35675410; PubMed Central PMCID: PMC9177073.

Chocron ES, Mdaki K, Jiang N, Cropper J, Pickering AM. Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function. Commun Biol. 2022 May 16;5(1):467. doi: 10.1038/s42003-022-03405-w. PubMed PMID: 35577894; PubMed Central PMCID: PMC9110405.

Kim HS, Son J, Lee D, Tsai J, Wang D, Chocron ES, Jeong S, Kittrell P, Murchison CF, Kennedy RE, Tobon A, Jackson CE, Pickering AM. Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset. BMC Neurol. 2022 Feb 21;22(1):62. doi: 10.1186/s12883-022-02586-5. PubMed PMID: 35189854; PubMed Central PMCID: PMC8862222.

Zhu Z, Achreja A, Meurs N, Animasahun O, Owen S, Mittal A, Parikh P, Lo TW, Franco-Barraza J, Shi J, Gunchick V, Sherman MH, Cukierman E, Pickering AM, Maitra A, Sahai V, Morgan MA, Nagrath S, Lawrence TS, Nagrath D. Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours. Nat Metab. 2020 Aug;2(8):775-792. doi: 10.1038/s42255-020-0226-5. Epub 2020 Jul 6. PubMed PMID: 32694827; PubMed Central PMCID: PMC7438275.

Osmulski PA, Karpowicz P, Jankowska E, Bohmann J, Pickering AM, Gaczyńska M. New Peptide-Based Pharmacophore Activates 20S Proteasome. Molecules. 2020 Mar 22;25(6). doi: 10.3390/molecules25061439. PubMed PMID: 32235805; PubMed Central PMCID: PMC7145288.

Munkácsy E, Chocron ES, Quintanilla L, Gendron CM, Pletcher SD, Pickering AM. Neuronal-specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age-related cognitive decline. Aging Cell. 2019 Oct;18(5):e13005. doi: 10.1111/acel.13005. Epub 2019 Jul 23. PubMed PMID: 31334599; PubMed Central PMCID: PMC6718538.

Chocron ES, Munkácsy E, Pickering AM. Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease. Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):285-297. doi: 10.1016/j.bbadis.2018.09.035. Epub 2018 Nov 9. Review. PubMed PMID: 30419337; PubMed Central PMCID: PMC6310633.

Giżyńska M, Witkowska J, Karpowicz P, Rostankowski R, Chocron ES, Pickering AM, Osmulski P, Gaczynska M, Jankowska E. Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity. J Med Chem. 2019 Jan 10;62(1):359-370. doi: 10.1021/acs.jmedchem.8b01025. Epub 2018 Dec 3. PubMed PMID: 30452262; PubMed Central PMCID: PMC6796967.

Pickering AM, Lehr M, Gendron CM, Pletcher SD, Miller RA. Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan. Aging Cell. 2017 Aug;16(4):683-692. doi: 10.1111/acel.12596. Epub 2017 May 5. PubMed PMID: 28474396; PubMed Central PMCID: PMC5506402.

Pickering AM, Lehr M, Kohler WJ, Han ML, Miller RA. Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage. J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):791-9. doi: 10.1093/gerona/glu115. Epub 2014 Jul 28. PubMed PMID: 25070662; PubMed Central PMCID: PMC4481684.

Pickering AM, Lehr M, Miller RA. Lifespan of mice and primates correlates with immunoproteasome expression. J Clin Invest. 2015 May;125(5):2059-68. doi: 10.1172/JCI80514. Epub 2015 Apr 13. PubMed PMID: 25866968; PubMed Central PMCID: PMC4463211.

Pickering AM, Staab TA, Tower J, Sieburth D, Davies KJ. A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol. 2013 Feb 15;216(Pt 4):543-53. doi: 10.1242/jeb.074757. Epub 2012 Oct 4. PubMed PMID: 23038734; PubMed Central PMCID: PMC3561776.

Pickering AM, Vojtovich L, Tower J, A Davies KJ. Oxidative stress adaptation with acute, chronic, and repeated stress. Free Radic Biol Med. 2013 Feb;55:109-18. doi: 10.1016/j.freeradbiomed.2012.11.001. Epub 2012 Nov 9. PubMed PMID: 23142766; PubMed Central PMCID: PMC3687790.

Pickering AM, Davies KJ. Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. Arch Biochem Biophys. 2012 Jul 15;523(2):181-90. doi: 10.1016/j.abb.2012.04.018. Epub 2012 Apr 30. PubMed PMID: 22564544; PubMed Central PMCID: PMC3384713.

Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJA. Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress. J Biol Chem. 2012 Mar 23;287(13):10021-10031. doi: 10.1074/jbc.M111.277145. Epub 2012 Feb 3. PubMed PMID: 22308036; PubMed Central PMCID: PMC3323025.

Pickering AM, Davies KJ. A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. Free Radic Biol Med. 2012 Jan 15;52(2):239-46. doi: 10.1016/j.freeradbiomed.2011.08.018. Epub 2011 Sep 14. PubMed PMID: 21988844; PubMed Central PMCID: PMC4212338.

Pickering AM, Davies KJ. Degradation of damaged proteins: the main function of the 20S proteasome. Prog Mol Biol Transl Sci. 2012;109:227-48. doi: 10.1016/B978-0-12-397863-9.00006-7. Review. PubMed PMID: 22727423; PubMed Central PMCID: PMC3710712.

Grune T, Catalgol B, Licht A, Ermak G, Pickering AM, Ngo JK, Davies KJ. HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic Biol Med. 2011 Oct 1;51(7):1355-64. doi: 10.1016/j.freeradbiomed.2011.06.015. Epub 2011 Jun 24. PubMed PMID: 21767633; PubMed Central PMCID: PMC3172204.

Pickering AM, Koop AL, Teoh CY, Ermak G, Grune T, Davies KJ. The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochem J. 2010 Dec 15;432(3):585-94. doi: 10.1042/BJ20100878. PubMed PMID: 20919990; PubMed Central PMCID: PMC3133595.

Nuzhdin SV, Brisson JA, Pickering A, Wayne ML, Harshman LG, McIntyre LM. Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster. BMC Genomics. 2009 Mar 24;10:124. doi: 10.1186/1471-2164-10-124. PubMed PMID: 19317915; PubMed Central PMCID: PMC2674066.