Publications

The list of full publications can be found in the following link (external link).

Qi F, Lennon VA*, Zhao S, Guo Y, Ding H, Liu C, Bartley WM, Chen T, Lucchinetti CF, Wu LJ *. 2026. Neutrophil-microglia interaction drives motor dysfunction in neuromyelitis optica model induced by subarachnoid AQP4-IgG. Journal of Clinical Investigation, e199706. Epub ahead of print. (external link)

Xie M, Liang Y, Miller AS, Pallegar PN, Umpierre AD, Wang N, Zhang S, Nagaraj NK, Fogarty ZC, Ghayal NB, Oskarsson B, Zhao S, Zheng J, Shi W, Akter M, Qi F, Nguyen AT, Dickson DW, Wu LJ *. 2025. Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration. Immunity, 58(12): 3113-3129. (external link)

Yi MH, Liu Y, Liu YU, Lee J, Hanumaihgari P, Parusel S, Bosco DB, Wang L, Zheng J, Shi W, Eauchai L, Chompoopong S, Hunt CL, Wu LJ *. 2025. Optogenetic activation of cortical microglia promotes neuronal activity and pain hypersensitivity. Cell Reports, 44(5): 115717. (external link)

Zhao S, Wang L, Kleidonas D, Qi F, Liang Y, Zheng J, Umpierre AD, Wu LJ*. 2025. Chemogenetic activation of microglial Gi signaling decreases microglial surveillance and impairs neuronal synchronization. Science Advances, 11(9): eado7829. (external link)

Umpierre AD^#, Li B^#, Ayasoufi K, Simon WL, Zhao S, Xie M, Thyen G, Hur B, Zheng J, Liang Y, Bosco DB, Maynes MA, Wu Z, Yu X, Sung J, Johnson AJ, Li Y*, Wu LJ*. 2024. Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis. Neuron, 112(12):1959-1977. (external link)

Wang L, Zheng J, Zhao S, Wan Y, Wang M, Bosco DB, Kuan CY, Richardson JR, Wu LJ*. 2024. CCR2⁺ monocytes replenish border-associated macrophages in the diseased brain. Cell Reports, 43(4):114120. (external link)

Zhao S, Umpierre AD, Wu LJ*. 2024. Tuning neural circuits and behaviors by microglia in the adult brain. Trends in Neuroscience, 47(3):181-194 (external link) (review).

Haruwaka K^#, Ying Y^#, Liang Y, Umpierre AD, Yi MH, Kremen V, Chen T, Xie T, Qi F, Zhao S, Zhang J, Liu YU, Dong H, Worrell GA, Wu LJ*. 2024. Microglia enhance neuronal activity by shielding inhibitory synapses. Nature Neuroscience, 27(3):449-461. (external link)

Zhao S#, Zheng J#, Wang L, Umpierre AD, Parusel S, Xie M, Dheer A, Ayasoufi K, Johnson AJ, Richardson JR, Wu LJ*. 2023. Chemogenetic manipulation of CX3CR1+ cells transiently induces hypolocomotion independent of microglia. Molecular Psychiatry, 28(7):2857-2871. (external link)

Xie M#, Liu YU#*, Zhao S, Zhang L, Bosco DB, Pang Y-P, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ*. 2022. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature Neuroscience, 25(1): 26-38. (external link)

Eyo UB#, Haruwaka K#, Mo M, Campos-Salazar AB, Wang L, Speros XS, Sabu S, Xu P, Wu LJ*. 2021. Microglia provide structural resolution to injured dendrites after severe seizures. Cell Reports, 35(5): 109080. (external link)

Yi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, Dheer A, Bosco DB, Dong H, Wu LJ*. 2021. Optogenetic activation of spinal microglia triggers chronic pain in mice. PLoS Biology, 19(3): 3001154. (external link)

Umpierre AD, Bystrom LL, Ying Y, Liu YU, Worrell G, Wu LJ*. 2020. Microglial calcium signaling is attuned to neuronal activity in awake mice. eLife, 9: e56502. (external link)

Chen T, Lennon VA, Liu YU, Bosco DB, Li Y, Yi MH, Zhu J, Wei S, Wu LJ*. 2020. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion. Journal of Clinical Investigation, 130(8):4025-4038. (external link)

Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, Wu LJ*. 2019. Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Nature Neuroscience, 22(11):1771-1781. (external link)

Mo M^#, Eyo UB^#, Xie M, Peng J, Bosco DB, Umpierre AD, Zhu X, Tian DS, Xu P*, Wu LJ*. 2019. Microglial P2Y12 receptors regulate seizure-induced neurogenesis and immature neuronal projections. Journal of Neuroscience, 39(47):9453-9464. (external link)

Eyo UB, Wu LJ*. 2019. Microglia: lifelong patrolling immune cells of the brain. Progress in Neurobiology, 179:101614 (external link) (review).

Zhou LJ^#, Peng J^#, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Li ZJ, Liu Y, Murugan M, Eyo UB, Umpierre AD, Xin WJ, Chen T, Li M, Wang H, Richardson JR, Tan Z*, Liu XG*, Wu LJ*. 2019. Microglia are indispensable for synaptic plasticity in the spinal dorsal horn and chronic pain. Cell Reports, 27(13):3844-3859. (external link)

Eyo UB, Mo M, Yi MH, Murugan M, Liu J, Yarlagadda R, Margolis D, Xu P*, Wu LJ*. 2018. P2Y12R-dependent translocation mechanisms gate the changing microglial landscape. Cell Reports, 23(4):959-966. (external link)

Tian D^#, Peng J^#, Murugan M, Feng L, Liu J, Eyo UB, Zhou LJ, Mogilevsky R, Wang W*, Wu LJ*. 2017. Chemokine CCL2-CCR2 signaling induces neuronal cell death via STAT3 activation and IL-1β production after status epilepticus. Journal of Neuroscience, 37(33):7878 –7892. (external link)

Gu N^#, Peng J^#, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H*, Wu LJ*. 2016. Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivities after peripheral nerve injury. Cell Reports, 16(3):605-14. (external link)

Peng J^#, Gu N^#, Zhou LJ, Eyo UB, Murugan M, Gan WB, Wu LJ*. 2016. Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nature Communications, 7:12029. (external link)

Eyo UB, Gu N, De S, Dong H, Richardson JR, Wu LJ*. 2015. Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium. Journal of Neuroscience, 35(6): 2417-2422. (external link)

Wu LJ*. 2014. Voltage-gated proton channel Hv1 in microglia. Neuroscientist, 20(6): 599-609 (external link) (review).

Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ*. 2014. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. Journal of Neuroscience, 34 (32): 10528-10540. (external link)

Wu LJ^#, Wu G^#, Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE*. 2012. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience, 15(4): 565-573. (external link)