Publications

The list of full publications can be found in the following link.

Umpierre AD^#, Li B^#, Ayasoufi K, Simon WL, Zhao S, Xie M, Thyen G, Hur B, Zheng J, Liang Y, Bosco DB, Maynes MA, Wu Z, Yu X, Sung J, Johnson AJ, Li Y*, Wu LJ*. 2024. Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis. Neuron, 112(12):1959-1977.

Wang L, Zheng J, Zhao S, Wan Y, Wang M, Bosco DB, Kuan CY, Richardson JR, Wu LJ*. 2024. CCR2⁺ monocytes replenish border-associated macrophages in the diseased brain. Cell Reports, 43(4):114120

Zhao S, Umpierre AD, Wu LJ*. 2024. Tuning neural circuits and behaviors by microglia in the adult brain. Trends in Neuroscience, 47(3):181-194 (review).

Haruwaka K^#, Ying Y^#, Liang Y, Umpierre AD, Yi MH, Kremen V, Chen T, Xie T, Qi F, Zhao S, Zhang J, Liu YU, Dong H, Worrell GA, Wu LJ*. 2024. Microglia enhance neuronal activity by shielding inhibitory synapses. Nature Neuroscience, 27(3):449-461

Zhao S#, Zheng J#, Wang L, Umpierre AD, Parusel S, Xie M, Dheer A, Ayasoufi K, Johnson AJ, Richardson JR, Wu LJ*. 2023. Chemogenetic manipulation of CX3CR1+ cells transiently induces hypolocomotion independent of microglia. Molecular Psychiatry, 28(7):2857-2871 .

Xie M#, Liu YU#*, Zhao S, Zhang L, Bosco DB, Pang Y-P, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ*. 2022. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature Neuroscience, 25(1): 26-38.

Eyo UB#, Haruwaka K#, Mo M, Campos-Salazar AB, Wang L, Speros XS, Sabu S, Xu P, Wu LJ*. 2021. Microglia provide structural resolution to injured dendrites after severe seizures. Cell Reports, 35(5): 109080.

Yi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, Dheer A, Bosco DB, Dong H, Wu LJ*. 2021. Optogenetic activation of spinal microglia triggers chronic pain in mice. PLoS Biology, 19(3): 3001154.

Umpierre AD, Bystrom LL, Ying Y, Liu YU, Worrell G, Wu LJ*. 2020. Microglial calcium signaling is attuned to neuronal activity in awake mice. eLife, 9: e56502.

Chen T, Lennon VA, Liu YU, Bosco DB, Li Y, Yi MH, Zhu J, Wei S, Wu LJ*. 2020. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion. Journal of Clinical Investigation, 130(8):4025-4038.

Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, Wu LJ*. 2019. Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Nature Neuroscience, 22(11):1771-1781.

Mo M^#, Eyo UB^#, Xie M, Peng J, Bosco DB, Umpierre AD, Zhu X, Tian DS, Xu P*, Wu LJ*. 2019. Microglial P2Y12 receptors regulate seizure-induced neurogenesis and immature neuronal projections. Journal of Neuroscience, 39(47):9453-9464.

Eyo UB, Wu LJ*. 2019. Microglia: lifelong patrolling immune cells of the brain. Progress in Neurobiology, 179:101614 (review).

Zhou LJ^#, Peng J^#, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Li ZJ, Liu Y, Murugan M, Eyo UB, Umpierre AD, Xin WJ, Chen T, Li M, Wang H, Richardson JR, Tan Z*, Liu XG*, Wu LJ*. 2019. Microglia are indispensable for synaptic plasticity in the spinal dorsal horn and chronic pain. Cell Reports, 27(13):3844-3859.

Eyo UB, Mo M, Yi MH, Murugan M, Liu J, Yarlagadda R, Margolis D, Xu P*, Wu LJ*. 2018. P2Y12R-dependent translocation mechanisms gate the changing microglial landscape. Cell Reports, 23(4):959-966.

Tian D^#, Peng J^#, Murugan M, Feng L, Liu J, Eyo UB, Zhou LJ, Mogilevsky R, Wang W*, Wu LJ*. 2017. Chemokine CCL2-CCR2 signaling induces neuronal cell death via STAT3 activation and IL-1β production after status epilepticus. Journal of Neuroscience, 37(33):7878 –7892.

Gu N^#, Peng J^#, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H*, Wu LJ*. 2016. Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivities after peripheral nerve injury. Cell Reports, 16(3):605-14.

Peng J^#, Gu N^#, Zhou LJ, Eyo UB, Murugan M, Gan WB, Wu LJ*. 2016. Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nature Communications, 7:12029.

Eyo UB, Gu N, De S, Dong H, Richardson JR, Wu LJ*. 2015. Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium. Journal of Neuroscience, 35(6): 2417-2422.

Wu LJ*. 2014. Voltage-gated proton channel Hv1 in microglia. Neuroscientist, 20(6): 599-609 (review).

Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ*. 2014. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. Journal of Neuroscience, 34 (32): 10528-10540.

Wu LJ^#, Wu G^#, Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE*. 2012. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience, 15(4): 565-573.