Biography
Dr. Neveu earned a BS in Biochemistry and Molecular Biology and a BS in Molecular Genetics at Oklahoma State University and obtained his PhD at the McGovern Medical School under the mentorship of John H. Byrne. He pursued his postdoctoral training at the Feinberg School of Medicine under the mentorship of James D. Surmeier. Dr. Neveu joined the Department of Neurobiology and Anatomy at the McGovern Medical School at UTHealth in 2019.
Areas of Interest
Research Interests
Despite extraordinary advances in the field of neuroscience, we have yet to bridge our understanding of ion channels, neurons, networks, and higher-order processes such as the generation of movement and learning and memory. My research employs traditional electrophysiology and high-throughput voltage-sensitive dye imaging to bridge the gap between microscopic and macroscopic neuroscience. My research uses Aplysia californica as a model system. This model has the advantage of having simple, easily characterizable behavior that is operated by a complex yet understandable nervous system. My research has four main approaches: voltage-sensitive dye imaging, electrophysiology, computation, and 3D-printing.
Recording from nearly all the neurons of a complex network during behavior has the potential to answer many outstanding questions in the field of neuroscience. My research uses voltage-sensitive dye imaging to simultaneously record the activity of 100s of neurons of the Aplysia feeding system with single-neuron resolution.
Another area of my research uses traditional electrophysiology to examine a beautiful feature of neurons called plateau potentials. Plateau potentials are important for many aspects of nervous system function, including behavior and learning. My research combines electrophysiology with computational modeling to understand the mechanism and role of plateau potentials in the nervous system. These computational models are then added to larger networks to gain a holistic understanding of learning and behavior.
My research combines many recording techniques and requires custom-built devices. Therefore, we design and 3D-print voltage-sensitive dye imaging systems to record from Aplysia nervous system. By combining all of these techniques, my research goals are to understand how neurons cooperate to produce learning and behavior.
Publications
- Liu RY, Neveu C, Smolen P, Cleary LJ, Byrne JH (2017) Superior long-term synaptic memory induced by combining dual pharmacological activation of PKA and ERK with an enhanced training protocol. Learn Mem 24:289-297. PMCID: PMC5473109.
- Cai Z, Neveu CL, Baxter DA, Byrne JH, Aazhang B (2017) Inferring neuronal network functional connectivity with directed information. J Neurophysiol 118:1055-1069. PMCID: PMC5547257.
- Neveu CL, Costa RM, Homma R, Nagayama S, Baxter DA, Byrne JH (2017) Unique configurations of compression and truncation of neuronal activity underlie L-DOPA-induced selection of motor patterns in Aplysia. eNeuro 4: 0206-0217. PMCID: PMC5654236.
- Young Y, Neveu CL, Byrne JH, and Aazhang B (2021) Inferring functional connectivity through graphical directed information. J Neural Eng. 18:046019. PMCID: PMC8600965.
- Momohara Y*, Neveu CL*, Chen H, Baxter DA, and Byrne JH (2022) Specific plasticity loci and their synergism mediate operant conditioning. J Neuroscience. 42:1211-1223. PMCID: PMC8883845. *co-first author
- Neveu CL, Baxter, DA and Byrne JH (2023) Voltage- and calcium-gated membrane currents tune the plateau potential properties of multiple neuron types in the feeding neural circuit. J Neuroscience. JN-RM-0789-23. PMID: 37699717.
- Neveu CL, Huan Y, Momohara Y, Patel PR, Chiel HJ, Chestek CA, Byrne JH (2023) Combining voltage-sensitive dye, carbon fiber array, and extracellular nerve electrodes using 3-D printed recording chamber and manipulators. J Neurosci Methods. 1:396. PMID: 37524249.