Breast Pathology, Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Surgical Pathology, Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Anatomic and Clinical Pathology, Department of Pathology and Laboratory Medicine, Scott and White Medical Center, Temple, TX
Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX
Nanjing Medical University, Nanjing, China

Areas of Interest

Clinical Interests

Breast Pathology and Head and Neck Pathology

Research Interests

I am actively engaged in translational and clinical research in the areas of breast and head and neck pathology, including the identification of aberrant signaling pathways related to high-risk precancerous lesions, carcinogenesis, tumor progression and metastasis. Other research interests include the roles of gene regulation and epigenetics in heart and craniofacial development.


Visit the PubMed profile page

  • Liao Y, Xiang Y, Zhao Z, and Ai D. Bayesian mixed-effect higher-order hidden Markov models with applications to predictive healthcare using electronic health records. IISE Transactions. 2024 January; :1-30. doi: 10.1080/24725854.2024.2302368.
  • Turashvili G, Gao Y, Ai D, Ewaz AM, Gjeorgjievski SG, Wang Q, Nguyen TTA, Zhang C, Li X. Low interobserver agreement among subspecialised breast pathologists in evaluating HER2-low breast cancer. Journal of Clinical Pathology. 2023 Sep 15:jcp-2023-209055. doi: 10.1136/jcp-2023-209055. Epub ahead of print. PMID: 37714693.
  • Turashvili G, Gjeorgjievski SG, Wang Q, Ewaz A, Ai D, Li X, Badve SS. Intraoperative assessment of axillary sentinel lymph nodes by telepathology. Breast Cancer Research and Treatment. 2023 Sep 9. doi: 10.1007/s10549-023-07101-z. Epub ahead of print. PMID: 37688667.
  • Ai D*, Turashvili G*, Gjorgova Gjeorgjievski S, Wang Q, Ewaz AM, Gao Y, Nguyen T, Zhang C, Li XY. Subspecialized Breast Pathologists Have Suboptimal Interobserver Agreement in Ki-67 Evaluation Using 20% as the Cutoff. Breast Cancer Research and Treatment. 2023 Dec 29. doi: 10.1007/s10549-023-07197-3. Epub ahead of print. PMID: 38157098.
  • Ai D*, Sweeney K, Li X. Short review of malignant adenomyoepithelioma of the breast. Human Pathology Reports. Volume 27, 2022, 300583 (*corresponding author).
  • Ai D*, Yao Y*, Yang F*, Huo L*, Chen, H*, Lu W, Soto LM, Jiang M, Raso, MG, Wang SF, Bell D, Liu JS, Wang HM, Tan, DF, Torres-Cabala C, Gan Q, Wu Y, Albarracin CT, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin A, Ding QQ. TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer. Modern Pathology. 2021 Apr;34(4):710-719. (*contributed equally)
  • Hu S, Alpert L, Cates JMM, Gonzalez RS, and the Rare GIST Risk Stratification Group (Ai D and et al.). Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs. Modern Pathology. 2021 Oct 26. doi: 10.1038/s41379-021-00949-w. PMID: 34702994.
  • Ai D, Zreik TR, Harris SF, Hill G, Shan Y. Primary epithelioid angiosarcoma of temporal bone with initial presentation of otalgia: a case report and review of the literature. Baylor University Medical Center Proceedings. 2017 Dec 6;31(1):84-87.
  • Wang W, Cortes JE, Lin P, Khoury JD, Ai D, Tang Z, Tang G, Jorgensen JL, Medeiros LJ, Hu S. Impact of trisomy 8 on treatment response and survival of patients with chronic myelogenous leukemia in the era of tyrosine kinase inhibitors. Leukemia. 2015 Nov; 29(11):2263-6.
  • Ai D, Liu W, Lu G, Patel KP, Chen Z. Extramedullary blast crisis as initial presentation in chronic myeloid leukemia with the e1a2 BCR-ABL1 transcript. Molecular and Clinical Oncology. 2015 Nov;3(6):1319-1322.
  • Wang W, Cortes JE, Lin P, Beaty MW, Ai D, Amin HM, McDonnell TJ, Ok CY, Kantarjian HM, Medeiros LJ, and Hu SM. Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors. Blood. 2015 Oct 1;126(14):1699-706.
  • Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY. Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. The Journal of Clinical Investigation. 2010 Feb;120(2):472-84.
  • Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M. Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proceedings of the National Academy of Sciences. 2008 Apr 22;105(16):6081-6.
  • Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF. Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proceedings of the National Academy of Sciences. 2007 May 29;104(22):9319-24. (Reviewed by Developmental Cell. 2007 Jul; 13(1):10-3).

Book Chapters:

  • Ai D, and Cata JP. Atrial fibrillation after surgery. General Surgery: Principles, Practice and Postoperative Complications. 2014.
  • Shan Y, Wu HW, Zhang DR, Ai D, Zreik R and Huang H. Soft tissue tumors, molecular diagnosis and pathology. Advances in Soft Tissue Tumors. 2022.