Message from the Chair

As a basic science department in a research intensive medical school the major mission of the Department of Biochemistry and Molecular Biology (BMB) is to conduct innovative and important biomedical research.  BMB is host to a diverse array of multidisciplinary research programs ranging from the analysis of molecules, membranes, mice and men.  Basic biomedical research is conducted in cell biology, structural biology, genetics, immunology, microbiology and neurobiology.  In addition, preclinical and translational research is carried out in areas of pulmonary disease, cardiovascular disease, hypertension, visual disorders, and sickle cell disease.
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Upcoming Seminar

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Latest News

UTHealth Biochemists Working to Learn More about Sickle Cell Disease

Dr. Xia and her team published their study titled “Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression” in the […]

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Faculty Collaboration Leads to Nature Publication

Research by Eric Wagner, Ph.D., and Ann-Bin Shyu, Ph.D. lead to discovering that a protein called CFIm25, critical to keeping messenger […]

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Michael Blackburn named the William S. Kilroy Sr., Chair in Pulmonary Disease

Dr. Michael Blackburn has been named the William S. Kilroy Sr., Chair in Pulmonary Disease. Dr. Blackburn is world-renowned for his […]

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Welcome Darren Boehning!

BMB welcomes Darren Boehning  and his lab to UTHealth.  Dr. Boehning is an associate professor and joins us from UTMB. […]

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Recent Publications

Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S.

Mol Cell. 2014 Aug 21;55(4):511-23. doi: 10.1016/j.molcel.2014.06.010. Epub 2014 Jul 10.

PMCID:PMC4142144

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Visualization of arrestin recruitment by a G-protein-coupled receptor

Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK, Skiniotis G, Lefkowitz RJ.

Nature. 2014 Aug 14;512(7513):218-22. doi: 10.1038/nature13430. Epub 2014 Jun 22.

PMCID:PMC4134437

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CFIm25 links Alternative Polyadenylation to Glioblastoma Tumor Suppression

Masamha CP, Xia Z, Yang J, Albrecht TR, Li M, Shyu AB#, Li W#, and Wagner EJ#. Nature, 2014, in press. (#: co-corresponding authors)

Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.

El Ayadi A, Stieren ES, Barral JM, Boehning D.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13416-21.  2012 Jul 30. PMID: 22847417

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Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.

Yoo SH, Mohawk JA, Siepka SM, Shan Y, Huh SK, Hong HK, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen ZJ, Green CB, Takahashi JS.

Cell. 2013 Feb 28;152(5):1091-105. doi: 10.1016/j.cell.2013.01.055.

PMID: 23452855

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