Education

PhD
Princeton University
Postdoctoral Fellow
Cornell University

Areas of Interests

Research Interests

Structure and function of Membrane proteins , Ligand gated ion channels

Research Information

Structure and function of neurotransmitter receptors

Communication between nerve cells serves as the basis of all brain activity, and one of the fundamental steps involved in signal transmission between the nerve cells, is the conversion of a “chemical” signal liberated at the end of one nerve cell, into an “electrical” signal at the second nerve cell. This step is mediated by a class of membrane bound proteins known as neurotransmitter receptors. Glutamate receptors belong to this family of proteins, and are the main excitatory receptors in the central nervous system.

Our laboratory is interested in gaining an understanding of agonist mediated activation and desensitization of this receptor by determining the structural changes in the protein induced by agonist binding. This is achieved by using various cutting edge spectroscopic methods that allow the characterization of the dynamic state structure of the proteins at a significantly higher resolution than X-ray structures. The structural changes thus determined are correlated to the functional consequences as measured by electrophysiological measurements. These investigations provide a detailed understanding of the agonist controlled function of the glutamate receptors and hence aid in the rational design of drugs targeting this group of important proteins that are involved in diverse neuropathologies, such as epilepsy and ischemia.

Jayaraman graphic

Chemical interactions, dynamics and function

Selected Publications

Sirrieh RE, MacLean DM, Jayaraman V. 2015. A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc. J Gen Physiol. 146(2):173-81.

MacLean DM, Ramaswamy SS, Du M, Howe JR, Jayaraman V. 2014. Stargazin promotes closure of the AMPA receptor ligand-binding domain. J Gen Physiol. 144(6):503-12.

Sirrieh RE, Maclean DM, Jayaraman V. 2013. Amino-terminal Domain Tetramer Organization and Structural Effects of Zinc Binding in the N-Methyl-D-aspartate (NMDA) Receptor. J Biol Chem. 288(31):22555-64.

Landes CF, Rambhadran A, Taylor JN, Salatan F, Jayaraman V. 2011. Structural landscape of isolated agonist-binding domains from single AMPA receptors. Nat Chem Biol. 7(3):168-73.