Research

  • Sickle Cell Disease

Notable Publications:

  1. Detrimental effects of adenosine signaling in sickle cell disease (Nature Medicine, 2011)
  2. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression (J Clin Invest. 2014)
  3. Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity (Blood, 2015)
  4. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling (J Clin Invest. 2008)

 

  • Preeclampsia

Notable Publications:

  1. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice (Nature Medicine, 2008)
  2. The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia (J Exp Med. 2009)
  3.  Angiotensin receptor agonistic autoantibody-mediated tumor necrosis factor-alpha induction contributes to increased soluble endoglin production in preeclampsia (Circulation, 2010)
  4. Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia (Circulation, 2015)

 

  • Erythrocyte Metabolism

Notable Publications:

  1. Beneficial role of erythrocyte adenosine A2B receptor-mediated AMPK activation in high altitude hypoxia (Circulation, 2016)
  2. Sphingosine 1 Phosphate Promotes Erythrocyte Glycolysis and Oxygen Release for Adaptation to High Altitude Hypoxia (Nat Commun. 2016)
  3. Erythrocytes retain hypoxic adenosine response for faster acclimatization on re-ascent (Nat Commun. 2017)

 

  • Renal and Cardiovascular Disease

Notable Publications:

  1. A2B adenosine receptor-mediated induction of IL-6 promotes CKD (J Am Soc Nephrol. 2011)
  2. Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage (Hypertension. 2012)
  3. Elevated ecto-5’-nucleotidase-Mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension (Circ Res. 2013)
  4. Elevated endothelial hypoxia-inducible factor-1α contributes to glomerular injury and promotes hypertensive chronic kidney disease (Hypertension. 2015)

 

  • Pain

Notable Publication:

  1. Sustained elevated adenosine signaling via ADORA2B promotes chronic pain by inducing immune-sensory crosstalk (Cell Rep. 2016)