Selected Publications

Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias FJ.  Mediator structure and rearrangements required for holoenzyme Formation.  Nature.  544:196-203.  2017.

Murakami K, Tsai KL, Kalisman N, Bushnell DA, Asturias FJ, Kornberg RD.  Structure of an RNA polymerase II pre-initiation complex.  Proc Natl Acad Sci USA.  112:13543-13548.  2015.

Tsai KL, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW and Asturias FJ.  Subunit architecture and functional modular rearrangements of the transcriptional Mediator complex.  Cell.  157:1430-1444.  2014.

Tsai KL, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW and Asturias FJ.  A conserved mediator-CDK8 kinase module association regulates mediator-RNA polymerase II interaction.  Nat Struct Mol Biol.  20:611-9.  2013.