Publications

Key Dessauer Lab Publications:
For citation statistics see google scholar

2023
Yen YC, Li Y, Chen CL, Klose T, Watts VJ, Dessauer CW, Tesmer JJG: Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ. bioRxiv. 2023 May 2;2023.05.02.539090. doi: 10.1101/2023.05.02.539090. Preprint

2022
Bavencoffe AG, Spence EA, Zhu MY, Garza-Carbajal A, Chu KE, Bloom OE, Dessauer CW, Walters ET: Macrophage Migration Inhibitory Factor (MIF) Makes Complex Contributions to Pain-Related Hyperactivity of Nociceptors after Spinal Cord Injury. J Neurosci. 2022 May 23;42(27):5463-80.

Baldwin, TA, Li, Y, Marsden, A,  Rinné S, Garza-Carbajal A, Schindler, RFR,  Zhang, M, Garcia, MA,  Reddy Venna, V, Decher N, Brand, T, Dessauer, CW: Popeye Domain-Containing Protein 1 Scaffolds a Complex of Adenylyl Cyclase 9 and the Potassium Channel TREK-1 in Heart. EMBO Rep 23(12):e55208. doi 10.15252/embr.202255208.

Qi C, Lavriha, P, Mehta, V, Khanppnavar, B, Mohammed, I, Li, Y, Lazaratos, M, Schaefer, JV, Dreier, B, Plückthun, A, Bondar, A-N, Dessauer, CW, Korkhov, VM: Structural basis of adenylyl cyclase 9 activation. Nature Communications, 13(1):1045, 2022.

Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS: Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiological Reviews. 102:815-857, 2022

Ferré S, Ciruela F, Dessauer CW, González-Maeso J, Hébert TE, Jockers R, Logothetis DE, Pardo L: G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs). Pharmacology & Therapeutics. 231:107977, 2022

2021
Lopez ER, Carbajal AG, Tian JB, Bavencoffe A, Zhu MX, Dessauer CW, Walters ET (2021) Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT4 receptors and cAMP-dependent mechanisms. Neuropharmacology 184:108408.

2020
Carbajal AG, Bavencoffe A, Walters ET, Dessauer CW (2020) Depolarization-dependent C-Raf signaling promotes hyperexcitability and reduces opioid sensitivity of isolated nociceptors after spinal cord injury. J Neuroscience, 40:6522-6535.

Lazar, AM, Irannejad, R., Baldwin, TA, Sundaram, AA, Gutkind, JS, Inoue, A, Dessauer, CW, von Zastrow, M. (2020) G protein-regulated endocytic trafficking of adenylyl cyclase type 9.  E Life, 9;9:e58039, 2020​

Berkey SC, Herrera JJ, Odem MA, Rahman S, Cheruvu SS, Cheng X, Walters ET, Dessauer CW, Bavencoffe AG. (2020) EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury. Neurobiol Pain 7: 100040.

2019
Baldwin TA, Li Y, Brand CS, Watts VJ, Dessauer CW (2019) Insights Into The Regulatory Properties of Human Adenylyl Cyclase Type 9. (2019) Mol Pharm, 95: 349-360.

Li, Y*, Hof*, T, Baldwin*, TA, Chen, L, Kass, RS, and Dessauer, CW (2019) Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase. Cells, 8(9). pii: E981

Marsden, AN and Dessauer, CW (2019) Nanometric Targeting of Type 9 Adenylyl Cyclase in Heart. Biochem Society Trans, 47(6):1749-1756.

Doyle, TB, Muntean, BS, Ejendal, KF, Hayes, MP, Soto-Velasquez, M, Martemyanov, KA, Dessauer, CW, Hu, C-D and Watts, VJ (2019) Identification of novel adenylyl cyclase 5 (AC5) signaling networks in D1 and D2 medium spiny neurons using bimolecular fluorescence complementation screening. Cells, 8(11), 1468

2018
Baldwin TA, Dessauer CW (2018) Function of Adenylyl Cyclase in Heart: the AKAP Connection. J Cardiovasc Dev Disease 16;5(1),2; doi:10.3390/jcdd5010002

​Navarro G, Cordomí A, Casadó-Anguera V, Moreno E, Cai NS, Cortés A, Canela EI, Dessauer CW, Casadó V, Pardo L, Lluís C, Ferré S (2018) Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase. Nat Commun. 28;9(1):1242. doi: 10.1038/s41467-018-03522-3.

Odem MA, Bavencoffe AG, Cassidy RM, Lopez ER, Tian J, Dessauer CW, Walters ET (2018) Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain. Pain. Jul 12. doi: 10.1097/j.pain.0000000000001341.

Luo J, Bavencoffe A, Yang P, Feng J, Yin S, Qian A, Yu W, Liu S, Gong X, Cai T, Walters ET, Dessauer CW, and Hu H (2018) Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain. J Neurosci. 38(2):474-483.

2017
Li Y, Baldwin TA, Wang Y, Subramaniam J, Carbajal AG, Brand CS, Cunha SR, and Dessauer CW (2017) Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction. Scientific Reports 7:5522.

Dessauer CW (2017) Shining a Light on GPCR Complexes. J Biol Chem 292(34):14290-14291.

Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, and Seifert R. (2017) International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev 69(2):93-139.

Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ. (2017) Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Science Signaling 10(467), eaah6381. 
​
2016
Bavencoffe, A., Li, Y., Wu, Z., Qang, Y., Herrera, J., Kennedy, E.J., Walters, E.T., and Dessauer, C.W. (2016) Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Associated with Altered Adenylyl Cyclase Regulation. J Neuroscience Feb 3;36(5):1660-8.

2015
Xie, K., Masuho, I., Shih, C.C., Cao Y., Sasaki, K., Lai, C.W., Han, P.L., Ueda, H., Dessauer, C.W., Ehrlich, M.E., Xu, B., Willardson, B.M. and Martemyanov, K.A. (2015) Stable G protein-effector in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. eLife, 10.7554/eLife.10451

Yakubovich D., Berlin, S., Kahanovitch U., Rubinstein, M., Tselnicker, I.F., Styr B., Keren-Raifman, T., Dessauer, C.W., and Dascal, N (2015) A Quantitative Model of the GIRK1/2 Channel Reveals that Its Basal and Evoked Activities are Controlled by Unequal Stoichiometry of Gα and Gβγ. PLoS Comput. Biology, Nov 6;11(11):e1004598_

Brand, C.S., Sadana, R., Malik, S., Smrcka, A.V., Dessauer, C.W. (2015) Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform Specific Use of Multiple Interaction Sites. Mol Pharm, 88(4):758-67.

2014
Tselnicker IF, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW, Dascal N. (2014) Dual regulation of G proteins and the G-protein-activated K+ channels by lithium. Proc Natl Acad Sci. 111(13):5018-23

Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N (2014) Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1. J Physiol. 592:5373-90.

Dvir, M., Strulovich, R., Sachyani, D., Cohen, I.B., Haitin, Y., Dessauer, C.W., Pongs, O., Kass, R.S., Hirsch, J., and Attali, B.: Long QT mutations disrupt IKS regulation by PKA and PIP2 at the same KCNQ1 helix C-KCNE1 interface.  J. Cell Sci., 127:3943-55, 2014

2013
Brand, CS, Hocker, HJ, Gorfe, AA, Cavasotto CN, and Dessauer CW (2013) Isoform Selectivity of Adenylyl Cyclase Inhibitors: Characterization of Known and Unknown Compounds. J Pharm Exp Ther, 347(2):265-75.  Highlighted in F1000

Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ (2013) Development of a high-throughput screening paradigm for the discovery of small molecule modulators of adenylyl cyclase: Identification of an adenylyl cyclase 2 inhibitor.  J Pharm Exp Ther, 347(2):276-87.

Scott., JD, Dessauer, CW, Tasken, K (2013) Creating order from chaos: Cellular regulation by kinase anchoring.  Annual Review of Pharmacology and Toxicology, 53:187-210.

Efendiev, R, Bavencoffe, A, Hu, H, Zhu, MX, and Dessauer, CW (2013) Scaffolding by A-Kinase Anchoring Protein Enhances Functional Coupling between Adenylyl Cyclase and TRPV1 Channel. J Biol Chem, 288(6):3929-37.

2012
Li, Y, Chen, L, Kass, RS, and Dessauer, CW (2012) The A-kinase anchoring protein Yotiao facilitates complex formation between type 9 adenylyl cyclase and the IKs potassium channel in heart. J Biol Chem, 287(35): 29315-29824.

Ejendal, KFK, Dessauer, CW, Hebert, TE, and Watts, VJ (2012) Dopamine D2 receptor-mediated heterologous sensitization of AC5 requires signalosome assembly, J Signal Trans, 2012: 210324-30.

Pulliainen, AT, Pieles, K, Brand, CS, Hauert, B, Böhm, A, Quebatte, M, Wepf, A, Gstaiger, M, Aebersold, R, Dessauer, CW, Dehio, C (2012) Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP production, Proc Natl Acad Sci, 109: 9581-9586.

Xie K., Masuho, I., Brand, C., Dessauer, C.W., and Martemyanov, K. (2012) Striatal G protein regulator RGS9-2/Gβ5 controls sensitization and temporal signaling of type 5 adenylyl cyclase. Science Signaling, 5(239): ra63.

2011
Efendiev R and Dessauer CW (2011) AKAPs and Adenylyl Cyclase in Cardiovascular Physiology and Pathology.  Journal of Cardiovascular Pharmacology 58, 339-344

Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N (2011) Two Distinct Aspects of Coupling between Gαi and GIRK Channel Revealed by Fluorescently-Labeled Gαi3 Subunits. J Biol Chem 286, 33223-33235

2010
Vayttaden, SJ, Friedman, J, Tran, TM, Rich, TC, Dessauer, CW, and Clark, RB: Quantitative Modeling of GRK-Mediated β2AR Regulation. PLoS Computational Biology, 6(1):e1000647 (1-14), 2010.

Berlin, S, Keren-Raifman, T, Castel, R, Rubinstein, M, Dessauer, CW, Ivanina, T and Dascal, N: Gαi and Gβγ jointly regulate the conformations of a Gβγ effector, the neuronal G-protein activated K+ channel (GIRK).  J Biol Chem, 285(9):6179-85, 2010.

Efendiev, R, Samelson, BK, Nguyen, BT, Phatarpekar, PV, Baameur, F, Scott, JD, and Dessauer, CW: AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC 5 and 6 to AMPA Receptors. J Biol Chem, 285(19):14450-8, 2010. Highlighted in Faculty of 1000, Must Read

Tselniker, I, Tsemahovich, V, Dessauer, CW, and Dascal, N.: Stargazin Modulates Neuronal Voltage-Dependent Ca2+ Channel Cav2.2 by a Gβγ-Dependent mechanism. J Biol Chem, 285(27): 20462-20471, 2010.

2009
Sadana, R and Dessauer, CW (2009) Physiological Roles for G-Protein Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies.  NeuroSignals, 17: 5-22.

Kapiloff, MA, Piggott, LA, Sadana, R, Li, J, Heredia, LA, Henson, E, Efendiev, R, and Dessauer, CW (2009) An adenylyl cyclase-mAKAPβ signaling complex maintains basal cAMP levels in cardiac myocytes.  J Biol Chem, 284: 284(35): 23540-23546.

Dessauer, CW (2009) Adenylyl Cyclase-AKAP Complexes: The Next Dimension in cAMP Signaling.  Mol Pharm, 76(5):935-941.

Sadana, R, Dascal, N, and Dessauer, CW (2009) N-terminus of Type 5 Adenylyl Cyclase Scaffolds Gs Heterotrimer.  Mol Pharm, 76(6), 1256-1264.

2008
Piggott LA, Bauman A, Scott JD and Dessauer CW (2008) The A-Kinase Anchoring Protein Yotiao Binds and Regulates Adenylyl Cyclase in Brain. Proc Natl Acad Sci, 105, 13835-13840.

2007
Gao, X, Sadana, R, Dessauer, CW, and Patel, TB: Conditional stimulation of Type V and VI Adenylyl Cyclases by G protein βγ Subunits.  J. Biol. Chem., 282(1): 294-302, 2007.

2006
Sayner, SL, Alexeyev, M, Dessauer, CW, and Stevens, T (2006) Soluble adenylyl cyclase reveals the significance of cAMP compartmentation on pulmonary microvascular endothelial cell barrier.  Circulation Res. 98: 675-681.

Bauman, A, Soughayer, J, Nguyen, BT, Willoughby, D, Wong, W, Hoshi, N, Langeberg, LK, Cooper, DMF, Dessauer, CW, and Scott, JD (2006) Dynamic regulation of cAMP synthesis through anchored PKA/Adenylyl cyclase V/VI complexes.  Molecular Cell, 23(6): 925-931.

2005
Nguyen, BT and Dessauer, CW (2005) Relaxin Stimulates PKCζ Translocation via PI3K to Increase cAMP Production in THP-1 Cells.  Mol. Endocrinol., 19: 1012-1023.

Chen-Goodspeed, M, Lukan, AN, and Dessauer, CW (2005) Modeling of Gαs and Gαi Regulation of Human Types V and VI Adenylyl Cyclase. J. Biol. Chem., 280: 1808-1816.

2003
Nguyen, B.T., Yang, L., Sanborn, B.M., and Dessauer, C.W.: Phosphoinositide 3-Kinase Activity is Required for Biphasic Stimulation of cyclic AMP by Relaxin.  Mol. Endocrinol. 17(6): 1075-84, 2003.

Salim, S., Sinnarajah, S., Kehrl, J.H., and Dessauer, C.W.: Identification of RGS2 and Type V Adenylyl Cyclase Interaction Sites.  J. Biol. Chem. 278: 15842 – 15849, 2003.

2002
Peleg S, Varon D, Ivanina T, Dessauer CW, Dascal N (2002) Galpha(i) Controls the Gating of the G Protein-Activated K(+) Channel, GIRK. Neuron 33(1): 87-99. Highlighted in Faculty of 1000

Dessauer, CW, Chen-Goodspeed, M, and Chen, J (2002) Mechanism of Giα-Mediated Inhibition of Type V Adenylyl Cyclase. J. Biol. Chem. 277(32): 28823-28829. Highlighted in Faculty of 1000

2001
Sinnarajah, S, Dessauer, CW, Srikumar, D, Chen, J, Yuen, J, Yilman, S, Dennis, JC, Morrison, EE, Vodyanoy, V, and Kehrl, JH (2001) RGS2 Regulates Signal Transduction in Olfactory Neurons by Attenuating Adenylyl Cyclase III Activation.  Nature 409: 1051-1055.

2000
Tesmer, JJG, Dessauer, CW, Sunahara, RK, Murray, LD, Johnson, RA, Gilman, AG, Sprang, SR (2000)  Molecular Basis for P-site Inhibition of Adenylyl Cyclase. Biochemistry  39:14464-14471.

1998
Dessauer, CW, Tesmer, JJG, Sprang, SR, and Gilman, AG (1998) Identification of a Giα Binding Site on Type V Adenylyl Cyclase.  J. Biol. Chem. 273: 25831-25839.

1997
Sunahara, RK, Dessauer, CW, Whisnant, RE, Kleuss, C, and Gilman, AG (1997)  Interaction of Gsα with the Cytosolic Domains of Mammalian Adenylyl Cyclase.  J. Biol. Chem. 272: 22265-22271.

Dessauer, CW, Scully, TT, and Gilman, AG (1997)  Interactions of Forskolin and ATP with the Cytosolic Domains of Mammalian Adenylyl Cyclase. J. Biol. Chem. 272: 22272-22277.

Dessauer, CW and Gilman, AG (1997) The Catalytic Mechanism of Mammalian Adenylyl Cyclase: Equilibrium Binding and Kinetic Analysis of P-site Inhibition.  J. Biol. Chem. 272: 27787-27795.

1996
Whisnant, RE, Gilman, AG, and Dessauer, CW (1996) Interaction of the Two Cytosolic Domains of Mammalian Adenylyl Cyclase.  Proc. Natl. Acad. Sci. 93: 6621-6625.
 
Dessauer, CW and Gilman, AG (1996) Purification and Characterization of a Soluble Form of Mammalian Adenylyl Cyclase.  J. Biol. Chem. 271:16967-16974.

Schreibmayer, W, Dessauer, CW, Vorobiov, D, Gilman AG, Lester, HA, Davidson, N, and Dascal, ND (1996) Inhibition of an Inwardly Rectifying K+ Channel by G protein a Subunits.  Nature, 380: 624-627.