Publications

Key Dessauer Lab Publications:
For citation statistics see google scholar (external link)

2023
Yen YC, Li Y, Chen CL, Klose T, Watts VJ, Dessauer CW, Tesmer JJG: Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ (external link). bioRxiv. 2023 May 2;2023.05.02.539090. doi: 10.1101/2023.05.02.539090. Preprint

2022
Bavencoffe AG, Spence EA, Zhu MY, Garza-Carbajal A, Chu KE, Bloom OE, Dessauer CW, Walters ET: Macrophage Migration Inhibitory Factor (MIF) Makes Complex Contributions to Pain-Related Hyperactivity of Nociceptors after Spinal Cord Injury. (external link) J Neurosci. 2022 May 23;42(27):5463-80.

Baldwin, TA, Li, Y, Marsden, A,  Rinné S, Garza-Carbajal A, Schindler, RFR,  Zhang, M, Garcia, MA,  Reddy Venna, V, Decher N, Brand, T, Dessauer, CW: Popeye Domain-Containing Protein 1 Scaffolds a Complex of Adenylyl Cyclase 9 and the Potassium Channel TREK-1 in Heart (external link). EMBO Rep 23(12):e55208. doi 10.15252/embr.202255208.

Qi C, Lavriha, P, Mehta, V, Khanppnavar, B, Mohammed, I, Li, Y, Lazaratos, M, Schaefer, JV, Dreier, B, Plückthun, A, Bondar, A-N, Dessauer, CW, Korkhov, VM: Structural basis of adenylyl cyclase 9 activation (external link). Nature Communications, 13(1):1045, 2022.

Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS: Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. (external link) Physiological Reviews. 102:815-857, 2022

Ferré S, Ciruela F, Dessauer CW, González-Maeso J, Hébert TE, Jockers R, Logothetis DE, Pardo L: G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs). (external link) Pharmacology & Therapeutics. 231:107977, 2022

2021
Lopez ER, Carbajal AG, Tian JB, Bavencoffe A, Zhu MX, Dessauer CW, Walters ET (2021) Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT4 receptors and cAMP-dependent mechanisms (external link). Neuropharmacology 184:108408.

2020
Carbajal AG, Bavencoffe A, Walters ET, Dessauer CW (2020) Depolarization-dependent C-Raf signaling promotes hyperexcitability and reduces opioid sensitivity of isolated nociceptors after spinal cord injury (external link). J Neuroscience, 40:6522-6535.

Lazar, AM, Irannejad, R., Baldwin, TA, Sundaram, AA, Gutkind, JS, Inoue, A, Dessauer, CW, von Zastrow, M. (2020) G protein-regulated endocytic trafficking of adenylyl cyclase type 9 (external link).  E Life, 9;9:e58039, 2020​

Berkey SC, Herrera JJ, Odem MA, Rahman S, Cheruvu SS, Cheng X, Walters ET, Dessauer CW, Bavencoffe AG. (2020) EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury (external link). Neurobiol Pain 7: 100040.

2019
Baldwin TA, Li Y, Brand CS, Watts VJ, Dessauer CW (2019) Insights Into The Regulatory Properties of Human Adenylyl Cyclase Type 9 (external link). (2019) Mol Pharm, 95: 349-360.

Li, Y*, Hof*, T, Baldwin*, TA, Chen, L, Kass, RS, and Dessauer, CW (2019) Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase (external link). Cells, 8(9). pii: E981

Marsden, AN and Dessauer, CW (2019) Nanometric Targeting of Type 9 Adenylyl Cyclase in Heart (external link). Biochem Society Trans, 47(6):1749-1756.

Doyle, TB, Muntean, BS, Ejendal, KF, Hayes, MP, Soto-Velasquez, M, Martemyanov, KA, Dessauer, CW, Hu, C-D and Watts, VJ (2019) Identification of novel adenylyl cyclase 5 (AC5) signaling networks in D1 and D2 medium spiny neurons using bimolecular fluorescence complementation screening (external link). Cells, 8(11), 1468

2018
Baldwin TA, Dessauer CW (2018) Function of Adenylyl Cyclase in Heart: the AKAP Connection (external link). J Cardiovasc Dev Disease 16;5(1),2; doi:10.3390/jcdd5010002

​Navarro G, Cordomí A, Casadó-Anguera V, Moreno E, Cai NS, Cortés A, Canela EI, Dessauer CW, Casadó V, Pardo L, Lluís C, Ferré S (2018) Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase. (external link) Nat Commun. 28;9(1):1242. doi: 10.1038/s41467-018-03522-3.

Odem MA, Bavencoffe AG, Cassidy RM, Lopez ER, Tian J, Dessauer CW, Walters ET (2018) Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain (external link). Pain. Jul 12. doi: 10.1097/j.pain.0000000000001341.

Luo J, Bavencoffe A, Yang P, Feng J, Yin S, Qian A, Yu W, Liu S, Gong X, Cai T, Walters ET, Dessauer CW, and Hu H (2018) Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain (external link). J Neurosci. 38(2):474-483.

2017
Li Y, Baldwin TA, Wang Y, Subramaniam J, Carbajal AG, Brand CS, Cunha SR, and Dessauer CW (2017) Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction (external link). Scientific Reports 7:5522.

Dessauer CW (2017) Shining a Light on GPCR Complexes. (external link) J Biol Chem 292(34):14290-14291.

Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, and Seifert R. (2017) International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases (external link). Pharmacol Rev 69(2):93-139.

Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ. (2017) Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties (external link). Science Signaling 10(467), eaah6381. 
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2016
Bavencoffe, A., Li, Y., Wu, Z., Qang, Y., Herrera, J., Kennedy, E.J., Walters, E.T., and Dessauer, C.W. (2016) Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Associated with Altered Adenylyl Cyclase Regulation. (external link) J Neuroscience Feb 3;36(5):1660-8.

2015
Xie, K., Masuho, I., Shih, C.C., Cao Y., Sasaki, K., Lai, C.W., Han, P.L., Ueda, H., Dessauer, C.W., Ehrlich, M.E., Xu, B., Willardson, B.M. and Martemyanov, K.A. (2015) Stable G protein-effector in striatal neurons: mechanism of assembly and role in neurotransmitter signaling (external link). eLife, 10.7554/eLife.10451

Yakubovich D., Berlin, S., Kahanovitch U., Rubinstein, M., Tselnicker, I.F., Styr B., Keren-Raifman, T., Dessauer, C.W., and Dascal, N (2015) A Quantitative Model of the GIRK1/2 Channel Reveals that Its Basal and Evoked Activities are Controlled by Unequal Stoichiometry of Gα and Gβγ (external link). PLoS Comput. Biology, Nov 6;11(11):e1004598_

Brand, C.S., Sadana, R., Malik, S., Smrcka, A.V., Dessauer, C.W. (2015) Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform Specific Use of Multiple Interaction Sites (external link). Mol Pharm, 88(4):758-67.

2014
Tselnicker IF, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW, Dascal N. (2014) Dual regulation of G proteins and the G-protein-activated K+ (external link) channels by lithium (external link). Proc Natl Acad Sci. 111(13):5018-23

Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N (2014) Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1 (external link). J Physiol. 592:5373-90.

Dvir, M., Strulovich, R., Sachyani, D., Cohen, I.B., Haitin, Y., Dessauer, C.W., Pongs, O., Kass, R.S., Hirsch, J., and Attali, B.: Long QT mutations disrupt IKS regulation by PKA and PIP2 at the same KCNQ1 helix C-KCNE1 interface (external link).  J. Cell Sci., 127:3943-55, 2014

2013
Brand, CS, Hocker, HJ, Gorfe, AA, Cavasotto CN, and Dessauer CW (2013) Isoform Selectivity of Adenylyl Cyclase Inhibitors: Characterization of Known and Unknown Compounds. (external link) J Pharm Exp Ther, 347(2):265-75.  Highlighted in F1000

Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ (2013) Development of a high-throughput screening paradigm for the discovery of small molecule modulators of adenylyl cyclase: Identification of an adenylyl cyclase 2 inhibitor (external link).  J Pharm Exp Ther, 347(2):276-87.

Scott., JD, Dessauer, CW, Tasken, K (2013) Creating order from chaos: Cellular regulation by kinase anchoring (external link).  Annual Review of Pharmacology and Toxicology, 53:187-210.

Efendiev, R, Bavencoffe, A, Hu, H, Zhu, MX, and Dessauer, CW (2013) Scaffolding by A-Kinase Anchoring Protein Enhances Functional Coupling between Adenylyl Cyclase and TRPV1 Channel. (external link) J Biol Chem, 288(6):3929-37.

2012
Li, Y, Chen, L, Kass, RS, and Dessauer, CW (2012) The A-kinase anchoring protein Yotiao facilitates complex formation between type 9 adenylyl cyclase and the IKs potassium channel in heart. (external link) J Biol Chem, 287(35): 29315-29824.

Ejendal, KFK, Dessauer, CW, Hebert, TE, and Watts, VJ (2012) Dopamine D2 receptor-mediated heterologous sensitization of AC5 requires signalosome assembly (external link), J Signal Trans, 2012: 210324-30.

Pulliainen, AT, Pieles, K, Brand, CS, Hauert, B, Böhm, A, Quebatte, M, Wepf, A, Gstaiger, M, Aebersold, R, Dessauer, CW, Dehio, C (2012) Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP production (external link), Proc Natl Acad Sci, 109: 9581-9586.

Xie K., Masuho, I., Brand, C., Dessauer, C.W., and Martemyanov, K. (2012) Striatal G protein regulator RGS9-2/Gβ5 controls sensitization and temporal signaling of type 5 adenylyl cyclase. (external link) Science Signaling, 5(239): ra63.

2011
Efendiev R and Dessauer CW (2011) AKAPs and Adenylyl Cyclase in Cardiovascular Physiology and Pathology (external link).  Journal of Cardiovascular Pharmacology 58, 339-344

Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N (2011) Two Distinct Aspects of Coupling between Gαi and GIRK Channel Revealed by Fluorescently-Labeled Gαi3 Subunits (external link). J Biol Chem 286, 33223-33235

2010
Vayttaden, SJ, Friedman, J, Tran, TM, Rich, TC, Dessauer, CW, and Clark, RB: Quantitative Modeling of GRK-Mediated β2AR Regulation (external link). PLoS Computational Biology, 6(1):e1000647 (1-14), 2010.

Berlin, S, Keren-Raifman, T, Castel, R, Rubinstein, M, Dessauer, CW, Ivanina, T and Dascal, N: Gαi and Gβγ jointly regulate the conformations of a Gβγ effector, the neuronal G-protein activated K+ channel (GIRK) (external link).  J Biol Chem, 285(9):6179-85, 2010.

Efendiev, R, Samelson, BK, Nguyen, BT, Phatarpekar, PV, Baameur, F, Scott, JD, and Dessauer, CW: AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC 5 and 6 to AMPA Receptors (external link). J Biol Chem, 285(19):14450-8, 2010. Highlighted in Faculty of 1000, Must Read

Tselniker, I, Tsemahovich, V, Dessauer, CW, and Dascal, N.: Stargazin Modulates Neuronal Voltage-Dependent Ca2+ Channel Cav2.2 by a Gβγ-Dependent mechanism (external link). J Biol Chem, 285(27): 20462-20471, 2010.

2009
Sadana, R and Dessauer, CW (2009) Physiological Roles for G-Protein Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies (external link).  NeuroSignals, 17: 5-22.

Kapiloff, MA, Piggott, LA, Sadana, R, Li, J, Heredia, LA, Henson, E, Efendiev, R, and Dessauer, CW (2009) An adenylyl cyclase-mAKAPβ signaling complex maintains basal cAMP levels in cardiac myocytes (external link).  J Biol Chem, 284: 284(35): 23540-23546.

Dessauer, CW (2009) Adenylyl Cyclase-AKAP Complexes: The Next Dimension in cAMP Signaling (external link).  Mol Pharm, 76(5):935-941.

Sadana, R, Dascal, N, and Dessauer, CW (2009) N-terminus of Type 5 Adenylyl Cyclase Scaffolds Gs Heterotrimer (external link).  Mol Pharm, 76(6), 1256-1264.

2008
Piggott LA, Bauman A, Scott JD and Dessauer CW (2008) The A-Kinase Anchoring Protein Yotiao Binds and Regulates Adenylyl Cyclase in Brain. (external link) Proc Natl Acad Sci, 105, 13835-13840.

2007
Gao, X, Sadana, R, Dessauer, CW, and Patel, TB: Conditional stimulation of Type V and VI Adenylyl Cyclases by G protein βγ Subunits (external link).  J. Biol. Chem., 282(1): 294-302, 2007.

2006
Sayner, SL, Alexeyev, M, Dessauer, CW, and Stevens, T (2006) Soluble adenylyl cyclase reveals the significance of cAMP compartmentation on pulmonary microvascular endothelial cell barrier. (external link)  Circulation Res. 98: 675-681.

Bauman, A, Soughayer, J, Nguyen, BT, Willoughby, D, Wong, W, Hoshi, N, Langeberg, LK, Cooper, DMF, Dessauer, CW, and Scott, JD (2006) Dynamic regulation of cAMP synthesis through anchored PKA/Adenylyl cyclase V/VI complexes (external link).  Molecular Cell, 23(6): 925-931.

2005
Nguyen, BT and Dessauer, CW (2005) Relaxin Stimulates PKCζ Translocation via PI3K to Increase cAMP Production in THP-1 Cells (external link).  Mol. Endocrinol., 19: 1012-1023.

Chen-Goodspeed, M, Lukan, AN, and Dessauer, CW (2005) Modeling of Gαs and Gαi Regulation of Human Types V and VI Adenylyl Cyclase (external link). J. Biol. Chem., 280: 1808-1816.

2003
Nguyen, B.T., Yang, L., Sanborn, B.M., and Dessauer, C.W.: Phosphoinositide 3-Kinase Activity is Required for Biphasic Stimulation of cyclic AMP by Relaxin (external link).  Mol. Endocrinol. 17(6): 1075-84, 2003.

Salim, S., Sinnarajah, S., Kehrl, J.H., and Dessauer, C.W.: Identification of RGS2 and Type V Adenylyl Cyclase Interaction Sites (external link).  J. Biol. Chem. 278: 15842 – 15849, 2003.

2002
Peleg S, Varon D, Ivanina T, Dessauer CW, Dascal N (2002) Galpha(i) Controls the Gating of the G Protein-Activated K(+) Channel, GIRK (external link). Neuron 33(1): 87-99. Highlighted in Faculty of 1000

Dessauer, CW, Chen-Goodspeed, M, and Chen, J (2002) Mechanism of Giα-Mediated Inhibition of Type V Adenylyl Cyclase (external link). J. Biol. Chem. 277(32): 28823-28829. Highlighted in Faculty of 1000

2001
Sinnarajah, S, Dessauer, CW, Srikumar, D, Chen, J, Yuen, J, Yilman, S, Dennis, JC, Morrison, EE, Vodyanoy, V, and Kehrl, JH (2001) RGS2 Regulates Signal Transduction in Olfactory Neurons by Attenuating Adenylyl Cyclase III Activation (external link).  Nature 409: 1051-1055.

2000
Tesmer, JJG, Dessauer, CW, Sunahara, RK, Murray, LD, Johnson, RA, Gilman, AG, Sprang, SR (2000)  Molecular Basis for P-site Inhibition of Adenylyl Cyclase (external link). Biochemistry  39:14464-14471.

1998
Dessauer, CW, Tesmer, JJG, Sprang, SR, and Gilman, AG (1998) Identification of a Giα Binding Site on Type V Adenylyl Cyclase (external link).  J. Biol. Chem. 273: 25831-25839.

1997
Sunahara, RK, Dessauer, CW, Whisnant, RE, Kleuss, C, and Gilman, AG (1997)  Interaction of Gsα with the Cytosolic Domains of Mammalian Adenylyl Cyclase (external link).  J. Biol. Chem. 272: 22265-22271.

Dessauer, CW, Scully, TT, and Gilman, AG (1997)  Interactions of Forskolin and ATP with the Cytosolic Domains of Mammalian Adenylyl Cyclase (external link). J. Biol. Chem. 272: 22272-22277.

Dessauer, CW and Gilman, AG (1997) The Catalytic Mechanism of Mammalian Adenylyl Cyclase: Equilibrium Binding and Kinetic Analysis of P-site Inhibition (external link).  J. Biol. Chem. 272: 27787-27795.

1996
Whisnant, RE, Gilman, AG, and Dessauer, CW (1996) Interaction of the Two Cytosolic Domains of Mammalian Adenylyl Cyclase (external link).  Proc. Natl. Acad. Sci. 93: 6621-6625.
 
Dessauer, CW and Gilman, AG (1996) Purification and Characterization of a Soluble Form of Mammalian Adenylyl Cyclase (external link).  J. Biol. Chem. 271:16967-16974.

Schreibmayer, W, Dessauer, CW, Vorobiov, D, Gilman AG, Lester, HA, Davidson, N, and Dascal, ND (1996) Inhibition of an Inwardly Rectifying K+ Channel by G protein a Subunits (external link).  Nature, 380: 624-627.