services dna

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Protein Production and Characterization

  • Produce gram quantities of antibodies and other proteins as needed for pharmacokinetic and toxicology studies
  • Characterize the proteins in detail, including purity, aggregation, and post-translational modification
  • Remove endotoxin for in vivo studies
  • Generate high-expressing stable cell lines with CHO cells



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Pharmacokinetic and Toxicology Study in Two Species

  • Determine pharmacokinetic parameters of drug candidates in rats and rhesus monkeys
  • Determine safety and potential toxicity of drug candidates in rats and rhesus monkeys with single and/or repeat dosing
  • Assess safety and potential toxicity by complete blood analysis and histopathology examination of major organs


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Imaging and Biodistribution in Tumor Models

  • Label drug candidates with radionuclides used for positron emission tomography (PET) or single-photon emission computed tomography (SPECT)
  • Perform whole-body imaging at up to 7 days post-injection to determine uptake levels of the labeled drug candidates in on-target and off-target tissues