About ADPKD

What is ADPKD?

ADPKD is a genetic condition in which fluid-filled cysts develop and enlarge over time, primarily in the kidneys but also in the liver and other organs. Over the years, cyst growth may increase kidney size and contribute to high blood pressure, pain, blood in urine, kidney stones, infections, and gradual loss of kidney function.

Prognosis, Progression, and Why Risk Matters

ADPKD progression varies widely—even within the same family. Early risk assessment helps identify who may benefit from disease-modifying therapy and closer monitoring.

How We Assess Risk of Progression:

• Kidney imaging (kidney size/total kidney volume trends)
• Rate of eGFR change over time
• Blood pressure and albumin/protein in urine
• Family history and age at kidney failure in relatives
• Genetic testing when indicated

What Patients Can Do Now:

• Blood pressure control and kidney-protective lifestyle
• Individualized nutrition guidance
• Monitoring for complications (stones, infections, cyst bleeding)
• Timely planning for advanced CKD and transplant evaluation when appropriate