Selected Publications
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge. (external link)
Nohara K1, Mallampalli V1, Nemkov T2, Wirianto M1, Yang J1, Ye Y1, Sun Y3, Han L1, Esser KA4, Mileykovskaya E1, D’Allesandro A2, Green CB5, Takahashi JS56, Dowhan W1, Yoo SH1, and Chen Z1.
Nature Communications 10: 3923, 2019.
PMID: 31462679
Temporal control of appetite by AgRP clocks. (external link)
Chen Z.
Cell Metabolism 29: 1022-1023, 2019.
PMID: 31067447
Development and therapeutic potential of small molecule regulators of circadian systems. (external link)
Chen Z, Yoo SH and Takahashi JS.
Annu Rev Pharmacol Toxicol. 58:231-252, 2018.
The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy. (external link)
Ye Y, Xiang Y, Ozguz FM, Kim Y, Liu C, Park PK, Hu Q, Diao L, Lou Y, Lin C, Guo A-Y, Zhou B, Wang L, Chen Z, Takahashi JS, Mills GB, Yoo, SH and Han L.
Cell Systems. 6: 314-328, 2018.
PMCID: PMC6056007
Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation. (external link)
Yoo SH, Kojima S, Shimomura K, Koike N, Buhr E, Furukawa T, Ko C, Gloston G, Ayoub C, Nohara K, Reyes B, Tsuchiya Y, Yoo O-J, Yagita K, Lee C, Chen Z, Yamakazi S, Green CB, and Takahashi JS.
Proc Natl Acad Sci USA. 114(42): E8855-E8864, 2017.
PMCID: PMC5651750
The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome. (external link)
He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH and Chen Z.
Cell Metabolism. 23: 610-21, 2016.
PMCID: PMC4832569
Transmissible microbial and metabolomic remodeling by soluble dietary fiber improves metabolic homeo (external link)
He B1, Nohara K1, Ajami NJ2, Michalek RD3, Tian X2, Wong M2, Losee-Olson SH4, Petrosino JF2, Yoo SH1, Shimomura K5, Chen Z1
Sci Rep. 5: 10604, 2015.
PMCID:PMC4455235
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. (external link)
Yoo SH, Mohawk JA, Siepka SM, Shan Y, Huh SK, Hong HK, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen ZJ, Green CB, Takahashi JS.
Cell. 152(5):1091-105, 2013.
PMID: 23452855
Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. (external link)
Chen Z, Yoo SH, Park YS, Kim KH, Wei S, Buhr E, Ye ZY, Pan HL, Takahashi JS.
Proc Natl Acad Sci U S A. 109(1):101-6, 2012.
PMCID: PMC3252927
Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity (external link)
Chen Z, Odstrcil EA, Tu BP, McKnight SL.
Science. 29;316(5833):1916-9, 2007.
PMID: 17600220