Selected Publications

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.
Nohara K1, Mallampalli V1, Nemkov T2, Wirianto M1, Yang J1, Ye Y1, Sun Y3, Han L1, Esser KA4, Mileykovskaya E1, D’Allesandro A2, Green CB5, Takahashi JS56, Dowhan W1, Yoo SH1, and Chen Z1.
Nature Communications 10: 3923, 2019.
PMID: 31462679

Temporal control of appetite by AgRP clocks.
Chen Z.
Cell Metabolism 29: 1022-1023, 2019.
PMID: 31067447

Development and therapeutic potential of small molecule regulators of circadian systems.
Chen Z, Yoo SH and Takahashi JS.
Annu Rev Pharmacol Toxicol. 58:231-252, 2018.

The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy.
Ye Y, Xiang Y, Ozguz FM, Kim Y, Liu C, Park PK, Hu Q, Diao L, Lou Y, Lin C, Guo A-Y, Zhou B, Wang L, Chen Z, Takahashi JS, Mills GB, Yoo, SH and Han L.
Cell Systems. 6: 314-328, 2018.
PMCID: PMC6056007

Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.
Yoo SH, Kojima S, Shimomura K, Koike N, Buhr E, Furukawa T, Ko C, Gloston G, Ayoub C, Nohara K, Reyes B, Tsuchiya Y, Yoo O-J, Yagita K, Lee C, Chen Z, Yamakazi S, Green CB, and Takahashi JS.
Proc Natl Acad Sci USA. 114(42): E8855-E8864, 2017.
PMCID: PMC5651750

The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome.
He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH and Chen Z.
Cell Metabolism. 23: 610-21, 2016.
PMCID: PMC4832569

Transmissible microbial and metabolomic remodeling by soluble dietary fiber improves metabolic homeo
He B1, Nohara K1, Ajami NJ2, Michalek RD3, Tian X2, Wong M2, Losee-Olson SH4, Petrosino JF2, Yoo SH1, Shimomura K5, Chen Z1
Sci Rep. 5: 10604, 2015.

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
Yoo SH, Mohawk JA, Siepka SM, Shan Y, Huh SK, Hong HK, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen ZJ, Green CB, Takahashi JS.
Cell. 152(5):1091-105, 2013.
PMID: 23452855

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening.
Chen Z, Yoo SH, Park YS, Kim KH, Wei S, Buhr E, Ye ZY, Pan HL, Takahashi JS.
Proc Natl Acad Sci U S A. 109(1):101-6, 2012.
PMCID: PMC3252927

Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity
Chen Z, Odstrcil EA, Tu BP, McKnight SL.
Science. 29;316(5833):1916-9, 2007.
PMID: 17600220