2. Laboratories
  3. Xia Laboratory
  4. Research

Research

  • Sickle Cell Disease

Notable Publications:

  1. Detrimental effects of adenosine signaling in sickle cell disease (external link) (Nature Medicine, 2011)
  2. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression (external link) (J Clin Invest. 2014)
  3. Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity (external link) (Blood, 2015)
  4. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling (external link) (J Clin Invest. 2008)

 

  • Preeclampsia

Notable Publications:

  1. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice (external link) (Nature Medicine, 2008)
  2. The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia (external link) (J Exp Med. 2009)
  3.  Angiotensin receptor agonistic autoantibody-mediated tumor necrosis factor-alpha induction contributes to increased soluble endoglin production in preeclampsia (external link) (Circulation, 2010)
  4. Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia (external link) (Circulation, 2015)

 

  • Erythrocyte Metabolism

Notable Publications:

  1. Beneficial role of erythrocyte adenosine A2B receptor-mediated AMPK activation in high altitude hypoxia (external link) (Circulation, 2016)
  2. Sphingosine 1 Phosphate Promotes Erythrocyte Glycolysis and Oxygen Release for Adaptation to High Altitude Hypoxia (external link) (Nat Commun. 2016)
  3. Erythrocytes retain hypoxic adenosine response for faster acclimatization on re-ascent (external link) (Nat Commun. 2017)

 

  • Renal and Cardiovascular Disease

Notable Publications:

  1. A2B adenosine receptor-mediated induction of IL-6 promotes CKD (external link) (J Am Soc Nephrol. 2011)
  2. Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage (external link) (Hypertension. 2012)
  3. Elevated (external link)ecto (external link)-5’-nucleotidase-Mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension (external link) (Circ Res. 2013)
  4. Elevated endothelial hypoxia-inducible factor-1α contributes to glomerular injury and promotes hypertensive chronic kidney disease (external link) (Hypertension. 2015)

 

  • Pain

Notable Publication:

  1. Sustained elevated adenosine signaling via ADORA2B promotes chronic pain by inducing immune-sensory crosstalk (external link) (Cell Rep. 2016)