Selected Publications

• Drug binding to cardiac troponin C.
  Kleerekoper Q¹, Putkey JA.
  J Biol Chem. 1999 Aug 20;274(34):23932-9.
  PMID: 10446160
• Interaction of cardiac troponin C with Ca(2+) sensitizer EMD 57033 and cardiac troponin I inhibitory peptide.
  Li MX¹, Spyracopoulos L, Beier N, Putkey JA, Sykes BD.
  Biochemistry. 2000 Aug 1;39(30):8782-90.
  PMID: 10913289
• Bepridil opens the regulatory N-terminal lobe of cardiac troponin C.
  Li Y¹, Love ML, Putkey JA, Cohen C.
  Proc Natl Acad Sci U S A. 2000 May 9;97(10):5140-5.
  PMCID: PMC25795
• Delta 469 mutation in the type 3 repeat calcium binding domain of cartilage oligomeric matrix protein (COMP) disrupts calcium binding.
  Hou J¹, Putkey JA, Hecht JT.
  Cell Calcium. 2000 Jun;27(6):309-14.
  PMID: 11013461
• Disease-causing mutations in cartilage oligomeric matrix protein cause an unstructured Ca2+ binding domain.
  Kleerekoper Q¹, Hecht JT, Putkey JA.
  J Biol Chem. 2002 Mar 22;277(12):10581-9. Epub 2002 Jan 8.
  PMID: 11782471
• A new role for IQ motif proteins in regulating calmodulin function.
  Putkey JA¹, Kleerekoper Q, Gaertner TR, Waxham MN.
  J Biol Chem. 2003 Dec 12;278(50):49667-70. Epub 2003 Oct 9.
  PMID: 14551202
• RC3/Neurogranin and Ca2+/calmodulin-dependent protein kinase II produce opposing effects on the affinity of calmodulin for calcium.
  Gaertner TR¹, Putkey JA, Waxham MN.
  J Biol Chem. 2004 Sep 17;279(38):39374-82. Epub 2004 Jul 15.
  PMID: 15262982
• Complex of calmodulin with a ryanodine receptor target reveals a novel, flexible binding mode.
  Maximciuc AA¹, Putkey JA, Shamoo Y, Mackenzie KR.
  Structure. 2006 Oct;14(10):1547-56.
  PMID: 17027503
• Acidic/IQ motif regulator of calmodulin.
  Putkey JA¹, Waxham MN, Gaertner TR, Brewer KJ, Goldsmith M, Kubota Y, Kleerekoper QK.
  J Biol Chem. 2008 Jan 18;283(3):1401-10. Epub 2007 Nov 8.
  PMCID: PMC3617039
• PEP-19, an intrinsically disordered regulator of calmodulin signaling.
  Kleerekoper QK¹, Putkey JA.
  J Biol Chem. 2009 Mar 20;284(12):7455-64. doi: 10.1074/jbc.M808067200. Epub 2008 Dec 23.
  PMCID: PMC2658041
• Intra- and interdomain effects due to mutation of calcium-binding sites in calmodulin.
  Xiong LW¹, Kleerekoper QK, Wang X, Putkey JA.
  J Biol Chem. 2010 Mar 12;285(11):8094-103. doi: 10.1074/jbc.M109.065243. Epub 2010 Jan 4.
  PMCID: PMC2832960
• Intrinsically disordered PEP-19 confers unique dynamic properties to apo and calcium calmodulin.
  Wang X¹, Kleerekoper QK, Xiong LW, Putkey JA.
  Biochemistry. 2010 Dec 7;49(48):10287-97. doi: 10.1021/bi100500m. Epub 2010 Nov 12.
  PMCID: PMC3001392
• Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding.
  Deng W¹, Srinivasan S, Zheng X, Putkey JA, Li R.
  J Mol Biol. 2011 Aug 5;411(1):220-33. doi: 10.1016/j.jmb.2011.05.041. Epub 2011 Jun 2.
  PMCID: PMC3143253
• The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release
  Wang X¹, Xiong LW, El Ayadi A, Boehning D, Putkey JA.
  J Biol Chem. 2013 Jan 18;288(3):2040-8. doi: 10.1074/jbc.M112.411314. Epub 2012 Nov 30.
  PMCID: PMC3548510
• Neurogranin alters the structure and calcium-binding properties of calmodulin
  Hoffman, L, Chandrasekar, A., Wang, X, Putkey, J.A., and Waxham M.N.
  J. Biol. Chem. 289: 14644-14655, 2014
  PMCID: PMC4031520
• PEP-19 modulates calcium binding to calmodulin by electrostatic steering.
  Wang, X and Putkey, JA
  Nat Commun 7, 13583 dol:  10.1038/ncomms13583, 2016.